Psych Flashcards

1
Q

ADHD treatment

A

Methylphenidate
amphetamines
atomoxetine

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2
Q

Tourette syndrome treament

A

antipsychotics

behavioral therapy

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3
Q

Seperation anxiety treatment

A

SSRIs

Relaxation treatment

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4
Q

Temporary control of delirium

A

Haloperidol

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5
Q

Electroconvulsive therapy used for

A

Pregnant women with MDD
MDD refractory to other treatment
For immediate response ie Suicide
Catatonia

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6
Q

Panic D/O treatment

A

SSRIs
Venlafaxine
Benzodiazepines

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7
Q

OCD treatment

A

SSRIs

Clomipramine

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8
Q

Treatment for alcohol withdrawal tremors

A

Benzodiazepines

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9
Q

Opioids overdose treatment

A

Naloxone

Naltrexone

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10
Q

Opioid withdrawal treament

A

buprenorphine

methadone

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11
Q

Treatment for benzo’s intoxication

A

Flumazenil

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12
Q

Treatment for cocaine intoxication

A

benzos

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13
Q

PCP intoxication treatment

A

Benzos

Rapid acting antipsychotics

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14
Q

Treatment for heroin abuse

A

Methadone

Naloxone + buprenorphine

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15
Q

Naloxone causes withdrawal only when

A

injected (vs orally)

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16
Q

Drug for alcoholism and how it wors

A

Disulfiram

conditions pt to abstain from alcohol

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17
Q

Bipolar treatment

A

Lithoum
valproic acid
carbamezepine
atypical antipsychotics

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18
Q

schizophrenia treatment

A

antipsychotics

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19
Q

List the CNS stimulants

A

Methyphenidate
dextroamphetamine
methamphetamine

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20
Q

CNS stimulants MOA

A

increase cathecolamines( esp NE and dopamine) at the synaptic cleft

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21
Q

CNS stimulant use

A

ADHD
narcolepsy
appetite control

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22
Q

List the antipsychotics aka neuroleptics

A

Haloperidol
trifluoperazine
thioridazine
chlorapromazine

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23
Q

MOA of the anitpsychotics

A

All (typicals) block D2 receptors increase cAMP

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24
Q

Antipsychotics uses

A

Schizophrenia–only + sxs
psychosis
acute mania
Tourette’s syndrome

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25
Antipsychotics toxicity
Extrapyramisal system side effects like dyskinesias hyperprolactinemia/galactorrhea Dry mouth constipation (block of muscarinic) Hypotesion( alpha1 block) sedation (histamine R block) Neuroleptic malignant syndrome(NMS) Tarduve dyskinesia
26
Describe the NMS and its treatment
Myoglobinuria, rigidity, autonomic instability, hyperexia | Dantrolene, D2 agonists---bromocriptine
27
Describe tardive dyskinesia that occurs as a result of long term use of antipsychotics
Stereotypic oral facial movements
28
List the high potency antipscyhotics and the specific toxicity associated with them
Trifluoperazine Fluphenazine haloperidol--neuroleptic malignant s and TD Extrapyramidal Sxs
29
List the low potency antipsychotics and their specific toxicities
``` chlorpromazine--corneal deposits thioridazine--retinal deposits Anticholinergic--drymouth and constipation antihistamine- sedation alpha 1 block--hypotension ```
30
List the atypical antipsychotics
``` Olanzapine clozapine quetiapine rieperidone aripiprazole ziprasidone ```
31
Atypical antipsychotics use
``` both + and - schizophrenic sxs bipolar d/o OCD Anxiety d/o depression mania tourette's ```
32
Atypical antipsychotics toxicity
fewer extrapyramidal ans anticholinergic SE | Olazapine and clozapine--significant weight gain
33
Clozapine requires what for this side effect
Weekly WBC monitoring--causes severe agranulocytosis and seizures
34
Ziprasidone may prolong
QT interval
35
Lithium uses
Mood stabilizers bipolar disorders blocks relapse and acute mania events SIADH
36
Lithium toxicity
``` LMNOP Tremors sedation edema heartblock hyptothyroidism polyuria--ADH antagonist Teratogen: Ebstein anomaly and malformation of great vessels ```
37
How does lithium cause Nephrogenic DI | Where is it aborbed in the kidney
it is an ADH antagonist | Almost all of it is RAB in PCT
38
Buspirone MOA and how long until effects are seen
stimulates 5-HT1A receptors | 1-2wks
39
Buspirone uses
Generalized anxiety d/o
40
Pluses of Buspirone
``` Does not cause sedation addiction tolerance does not intervere with alcohol ```
41
List the SSRIs
Fluoxetine Paroxetine Sertraline citalopram
42
SSRIs MOA and time to take effect
specific Serotonin reuptake inhibitors | 4-8 wks
43
SSRIs use
``` Depression generalized anxiety d/o panic d/o OCD bulimia social phobias PTSD ```
44
SSRIs toxicity
``` Gi distress Sexual dysfunction Seratonin syndrome with any drug that increases seratonin hypothermia confusion myoclonus cardiovascular colapse flushing diarrhea seizures ```
45
Treatment of seratonin toxicity
cyproheptadine---5-HT2 receptor antagonist
46
List the SNRIs
Venlafaxine | duloxetine
47
SNRIs MOA
inhibits Serotonin and NE reuptake
48
SNRIs uses
depression Venlafaxine---also generalized anxiety d/o, panic d/o Duoxetine---also for DM peripheral neuropathy
49
SNRIs toxicity
increase BP | some stimulant effect: sedation, nausea
50
List the Tricyclic antidepressants
``` Amitryptiline northptyline imipramine desipramine Clomipramine doxepin aamoxapine ```
51
Tricyclics MOA
block re-uptake of NE and serotonin
52
TCAs uses
MDD bedwetting--imipramine OCD---clomipramine fibromyalgia
53
TCA antidepressants toxicity
``` sedation postural hypotension (alpha 1 blocking) Atropine-like SE: tachy, urinary retension, dry mouth( greater in amytiptyline) higher seizure threshold--desipramine confusin especially elderly hallucinations respiratory depression hyperpyrexia ```
54
what are three C's of TCA's | and treatment for the last C
Convulsions Coma Cardiotoxicity--arrythmias NaHCO3
55
list the Monoamine oxidase MOA inhibitors
Tranylcypromine phenelzine Isocarcoxazid Selegiline
56
Selegiline is a
MOA-B inhibitor
57
MAO inhibitors MOA
Noselectively increase the levels of all amine NTs including NE serotonin dopamine
58
MAO inhbitor uses
atypical depression anxiety hypochondriasis
59
MOA inhibitor toxicity
Hypertensive crisis--with cheese and whine(tyramine) | CNS stimulation
60
MAO inhibitor use is contraindicated with to prevent serotonin syndrome
``` SSRIs TCAs St John's Wort Meperidine Dextromethorphan ```
61
List the atypical antidepressants
Bupropion Mirtazapine Maprotiline Trazodone
62
Bupropion MOA and use
increases NE and dopamine | depression ans smoking cessation
63
Bupropion with no sexual SEs toxicity
Tachy insomnia HA seizures in bulimic pts
64
Mirtazapine MOA and use
alpha 2 antagonist: increase NE and serotonin release Potent 5-HT2 and 3 receptor antagonist Depression
65
Mirtazapine toxicity
Sedation--not so great in depressed increased appetite weight gain--may be good for elderly dry mouth
66
Maprotiline MOA and use
Blocks NE reuptake | Depression
67
Maprotiline toxicity
Sedation | orthostatic hypotension
68
Trazodone MOA and use
inhibits serotonin reuptake | insomnia and antidepressants in high doses
69
Trazodone toxicity
Sedation nausea priaprism postural hypotension
70
Treatment of acute mania
Mood stabilizers including: lithum, valproate, carbamazepin | Plus atypical antipsychotic: olanzapine