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Pharmacology > Psych > Flashcards

Psych Flashcards

1
Q

ADHD treatment

A

Methylphenidate
amphetamines
atomoxetine

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2
Q

Tourette syndrome treament

A

antipsychotics

behavioral therapy

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3
Q

Seperation anxiety treatment

A

SSRIs

Relaxation treatment

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4
Q

Temporary control of delirium

A

Haloperidol

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5
Q

Electroconvulsive therapy used for

A

Pregnant women with MDD
MDD refractory to other treatment
For immediate response ie Suicide
Catatonia

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6
Q

Panic D/O treatment

A

SSRIs
Venlafaxine
Benzodiazepines

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7
Q

OCD treatment

A

SSRIs

Clomipramine

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8
Q

Treatment for alcohol withdrawal tremors

A

Benzodiazepines

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9
Q

Opioids overdose treatment

A

Naloxone

Naltrexone

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10
Q

Opioid withdrawal treament

A

buprenorphine

methadone

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11
Q

Treatment for benzo’s intoxication

A

Flumazenil

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12
Q

Treatment for cocaine intoxication

A

benzos

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13
Q

PCP intoxication treatment

A

Benzos

Rapid acting antipsychotics

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14
Q

Treatment for heroin abuse

A

Methadone

Naloxone + buprenorphine

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15
Q

Naloxone causes withdrawal only when

A

injected (vs orally)

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16
Q

Drug for alcoholism and how it wors

A

Disulfiram

conditions pt to abstain from alcohol

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17
Q

Bipolar treatment

A

Lithoum
valproic acid
carbamezepine
atypical antipsychotics

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18
Q

schizophrenia treatment

A

antipsychotics

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19
Q

List the CNS stimulants

A

Methyphenidate
dextroamphetamine
methamphetamine

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20
Q

CNS stimulants MOA

A

increase cathecolamines( esp NE and dopamine) at the synaptic cleft

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21
Q

CNS stimulant use

A

ADHD
narcolepsy
appetite control

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22
Q

List the antipsychotics aka neuroleptics

A

Haloperidol
trifluoperazine
thioridazine
chlorapromazine

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23
Q

MOA of the anitpsychotics

A

All (typicals) block D2 receptors increase cAMP

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24
Q

Antipsychotics uses

A

Schizophrenia–only + sxs
psychosis
acute mania
Tourette’s syndrome

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25
Q

Antipsychotics toxicity

A

Extrapyramisal system side effects like dyskinesias
hyperprolactinemia/galactorrhea
Dry mouth constipation (block of muscarinic)
Hypotesion( alpha1 block)
sedation (histamine R block)
Neuroleptic malignant syndrome(NMS)
Tarduve dyskinesia

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26
Q

Describe the NMS and its treatment

A

Myoglobinuria, rigidity, autonomic instability, hyperexia

Dantrolene, D2 agonists—bromocriptine

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27
Q

Describe tardive dyskinesia that occurs as a result of long term use of antipsychotics

A

Stereotypic oral facial movements

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28
Q

List the high potency antipscyhotics and the specific toxicity associated with them

A

Trifluoperazine
Fluphenazine
haloperidol–neuroleptic malignant s and TD

Extrapyramidal Sxs

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29
Q

List the low potency antipsychotics and their specific toxicities

A 
chlorpromazine--corneal deposits
thioridazine--retinal deposits
Anticholinergic--drymouth and constipation
antihistamine- sedation
alpha 1 block--hypotension
30
Q

List the atypical antipsychotics

A 
Olanzapine
clozapine
quetiapine
rieperidone
aripiprazole
ziprasidone
31
Q

Atypical antipsychotics use

A 
both + and - schizophrenic sxs
bipolar d/o
OCD
Anxiety d/o
depression
mania
tourette's
32
Q

Atypical antipsychotics toxicity

A

fewer extrapyramidal ans anticholinergic SE

Olazapine and clozapine–significant weight gain

33
Q

Clozapine requires what for this side effect

A

Weekly WBC monitoring–causes severe agranulocytosis and seizures

34
Q

Ziprasidone may prolong

A

QT interval

35
Q

Lithium uses

A

Mood stabilizers bipolar disorders
blocks relapse and acute mania events
SIADH

36
Q

Lithium toxicity

A 
LMNOP
Tremors
sedation
edema
heartblock
hyptothyroidism
polyuria--ADH antagonist 
Teratogen: Ebstein anomaly and malformation of great vessels
37
Q

How does lithium cause Nephrogenic DI

Where is it aborbed in the kidney

A

it is an ADH antagonist

Almost all of it is RAB in PCT

38
Q

Buspirone MOA and how long until effects are seen

A

stimulates 5-HT1A receptors

1-2wks

39
Q

Buspirone uses

A

Generalized anxiety d/o

40
Q

Pluses of Buspirone

A 
Does not cause
sedation
addiction
tolerance
does not intervere with alcohol
41
Q

List the SSRIs

A

Fluoxetine
Paroxetine
Sertraline
citalopram

42
Q

SSRIs MOA and time to take effect

A

specific Serotonin reuptake inhibitors

4-8 wks

43
Q

SSRIs use

A 
Depression
generalized anxiety d/o
panic d/o
OCD
bulimia
social phobias
PTSD
44
Q

SSRIs toxicity

A 
Gi distress
Sexual dysfunction
Seratonin syndrome with any drug that increases seratonin
hypothermia
confusion
myoclonus
cardiovascular colapse
flushing 
diarrhea
seizures
45
Q

Treatment of seratonin toxicity

A

cyproheptadine—5-HT2 receptor antagonist

46
Q

List the SNRIs

A

Venlafaxine

duloxetine

47
Q

SNRIs MOA

A

inhibits Serotonin and NE reuptake

48
Q

SNRIs uses

A

depression
Venlafaxine—also generalized anxiety d/o, panic d/o
Duoxetine—also for DM peripheral neuropathy

49
Q

SNRIs toxicity

A

increase BP

some stimulant effect: sedation, nausea

50
Q

List the Tricyclic antidepressants

A 
Amitryptiline
northptyline
imipramine
desipramine
Clomipramine
doxepin
aamoxapine
51
Q

Tricyclics MOA

A

block re-uptake of NE and serotonin

52
Q

TCAs uses

A

MDD
bedwetting–imipramine
OCD—clomipramine
fibromyalgia

53
Q

TCA antidepressants toxicity

A 
sedation
postural hypotension (alpha 1 blocking)
Atropine-like SE: tachy, urinary retension, dry mouth( greater in amytiptyline)
higher seizure threshold--desipramine
confusin especially elderly
hallucinations
respiratory depression
hyperpyrexia
54
Q

what are three C’s of TCA’s

and treatment for the last C

A

Convulsions
Coma
Cardiotoxicity–arrythmias
NaHCO3

55
Q

list the Monoamine oxidase MOA inhibitors

A

Tranylcypromine
phenelzine
Isocarcoxazid
Selegiline

56
Q

Selegiline is a

A

MOA-B inhibitor

57
Q

MAO inhibitors MOA

A

Noselectively increase the levels of all amine NTs including
NE
serotonin
dopamine

58
Q

MAO inhbitor uses

A

atypical depression
anxiety
hypochondriasis

59
Q

MOA inhibitor toxicity

A

Hypertensive crisis–with cheese and whine(tyramine)

CNS stimulation

60
Q

MAO inhibitor use is contraindicated with to prevent serotonin syndrome

A 
SSRIs
TCAs
St John's Wort
Meperidine
Dextromethorphan
61
Q

List the atypical antidepressants

A

Bupropion
Mirtazapine
Maprotiline
Trazodone

62
Q

Bupropion MOA and use

A

increases NE and dopamine

depression ans smoking cessation

63
Q

Bupropion with no sexual SEs toxicity

A

Tachy
insomnia
HA
seizures in bulimic pts

64
Q

Mirtazapine MOA and use

A

alpha 2 antagonist: increase NE and serotonin release
Potent 5-HT2 and 3 receptor antagonist
Depression

65
Q

Mirtazapine toxicity

A

Sedation–not so great in depressed
increased appetite
weight gain–may be good for elderly
dry mouth

66
Q

Maprotiline MOA and use

A

Blocks NE reuptake

Depression

67
Q

Maprotiline toxicity

A

Sedation

orthostatic hypotension

68
Q

Trazodone MOA and use

A

inhibits serotonin reuptake

insomnia and antidepressants in high doses

69
Q

Trazodone toxicity

A

Sedation
nausea
priaprism
postural hypotension

70
Q

Treatment of acute mania

A

Mood stabilizers including: lithum, valproate, carbamazepin

Plus atypical antipsychotic: olanzapine

Pharmacology (13 decks)

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