Immune drugs

Question 1

cyclosporine clinical use

Answer 1

suppresses organ rejection after transplantation

Question 2

cyclosporin MOA : forms a complex with ?

Answer 2

cyclophilins

Question 3

cyclosporine/cyclophilin complex MOA

Answer 3

block T cells activation and differentiation by inhibiting calcineurin= no IL-2 and cytokine

Question 4

Cyclosporins toxicities

Answer 4

Nephrotoxicity
HTN
Hyperlipedemia
hyperglycemia
tremor
gingival hyperplasia
hirsutism

Question 5

Tacrolimus MOA

Answer 5

Inhibits calceneurin by binding to the FK-binding protein

Question 6

Tacrolimus clinical use

Answer 6

Potent immunosuppressant

Question 7

Tacrolimus toxicities

Answer 7

same as cyclosporines except no hirsutism or gingival hyperplasia

Question 8

Sicrolimus MOA

Answer 8

Inhibits mTOR leading to decreased T-cell proliferation

Question 9

Sicrolimus in addition to immunosupressing is used for

Answer 9

Drug eluting stents

Question 10

Sircolimus toxicities

Answer 10

Hyperlipidemia
thrombocytopenia
leukopenia

Question 11

Azathioprine clinical use

Answer 11

Kidney transplants

AI diseases– glomerulonephritis and hemolytic anemia

Question 12

Azathiprine is toxic to

Answer 12

proliferating lymphocytes

Question 13

Azathioprine MOA

Answer 13

It is an antimetabolite precursor of 6-mercaptopurine that interferes with synthesis of nucleic acid

Question 14

Azathioprine toxicities

Answer 14

Bone marrow suppression

Question 15

Why is azathioprine toxicity worse with allopurinol

Answer 15

because its active metabolite 6MCP is metabolized by xanthine oxidase

Question 16

Muromonab-CD3 clinical use

Answer 16

Immunosuppressant after kidney transplant

Question 17

Muromonab-CD3(OKT3)

Answer 17

AB that bind CD3 on surface of Tcells blocking signal transduction

Question 18

Muromonab-CD#(OKT3) toxicity

Answer 18

Cytokine release syndrome

hypersensitivity reaction

Question 19

Digoxin immune Fab use

Answer 19

is a AB used for antidote for digoxin intoxication

Question 20

Infliximab is and AB that targets

Answer 20

TNF-alph

Question 21

Infliximab clinical use

Answer 21

Crohn’s
RA
Psoriatic arthritis
ankylosis spondylitis

Question 22

Adalimumab target and clinical use

Answer 22

TNF-Alpha
Crohn’s
RA
PA

Question 23

Abciximab target and use

Answer 23

Glycoprotein IIB/IIIa
Unstable angina to prevent cardiac ischemia
pts treated with percutaneous coronary intervention

Question 24

Trastuzumab target and use

Answer 24

HER2

HER2 BCA

Question 25

Retuximab target and use

Answer 25

CD20 | B-cell non-Hodgkin's lymphoma

Question 26

Omalizumab target and use

Answer 26

IGE | Add-on for severe anemia

Question 27

Aldesleukin (interleukin-2) MOA and use

Answer 27

``` recombinant cytokine (RC) Renal cell carcinoma and metastatic melanoma ```

Question 28

Epoetin alfa MOA and use

Answer 28

RC | Anemia

Question 29

Filgrastim MOA and use

Answer 29

granulocyte colony stimulation | recovery of Bone marrow--such as neutropenia

Question 30

Sargramostin MOA and use

Answer 30

granulocyte and macrophage colony stimulatinf factor | recovery of bone marrow--such as neutropenia in CA pts

Question 31

IFN alpha use

Answer 31

HEP B and C Kaposi's sarcoma Leukemias malignant melanoma

Question 32

IFN beta use

Answer 32

MS

Question 33

IFN gamma use

Answer 33

Chronic granulomatous disease

Question 34

Oprelvekin MOA and use

Answer 34

Interleukin-11 | Thrombocytopenia

Question 35

Thrombopoietin use

Answer 35

Thrombocytopenia