Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > GI drugs > Flashcards

GI drugs Flashcards

1
Q

Name a motilin receptor agonist that can stimulate intestinal peristalsis

A

erythromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Treatment of hereditary hemachromatosis

A

Phlebotomy
deferasirox
deferoxamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Treatment of wilson’s disease and MOA

A

D-Penicilliamine

chelation of copper

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

List the H2 blockers

A 
Cimetidine
ranitidine
famotidine
nizatidine
Hint: DINE with histamine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA of the H2 blockers

A

reversible block of histamine receptor leading to decreased acid secretion from parietal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

H2 blocker clinical use

A

Peptic ulcer disease
mild esophageal reflux
gastritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cimentidine side effect

A

potent P450 inhibitor
antiandrogenic effect: Prolactin release, gynecomastia, impotence and decrease libido in males
crosses BB to cause confusion, dizziness and HA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Common toxicity shared by cimentidine and ranitidine

A

decrease serum excretion of creatinine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

List the proton pump inhibitors

A 
Omeprazole
lansoprazole
esomeprazole
pantoprazole
dexlansoprazole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Proton pump inhibitor MOA

A

irreversibly inhibit the H+/K+ ATPasse in the stomach parietal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Proton pump inhibitor uses

A

Peptic ulcer
gastritis
esophageal reflux
zollinger-ellison syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Proton pump inhibitor toxicity

A 
Increased risk of
 C.diff
f vibreo cholera
pneumonia
hip fxs
decreased Mg2+
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Bismuth and sucralfate clinical use

A

increase ulcer healing

traveler’s diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Bismuth and sucrafate MOA

A

bind to ulcer base providing physical protection and allows HCO3- secretion to reestablish pH gradient in mucous layer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Misoprostol MOA

A

PGE1 analog that increases the production and secretion of gastric mucous barrier
Decrease acid production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Misoprostol uses

A

Prevention of NSAID induced peptic ulcers
PDA maintainance
Ripen the cervix to induce labor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Misoprostol toxicity

A

Diarrhea

18
Q

Misoprostol is contraindicated in

A

women of childbearing potention–abortifacient

19
Q

octreotide uses

A

Acute variceal bleeds
acromegaly
VIPoma
carcinoid tumor

20
Q

Octreotide MOA

A

a Long acting Somatostatin analog

21
Q

Octreodie toxicity

A

Nausea
cramps
steatorrhea

22
Q

List the antiacids

A

Aluminum hydroxide
magnesium hydroxide
calcium carbonate

23
Q

Clinical consequences of antacids

A

hypokalemia
affect the absorption , urinary excretion, bioavailabilty of other durgs by delaying gastric empty and lowering pH of urine

24
Q

Aluminum hydroxide toxicity

A 
constipation
hypophosphatemia
proximal muscle weakness
osteodystrophy
seizures
25
Q

Magnesium OH toxicity

A

Diarrhea
hyporeflexia
Hypotension
cardiac arrest

26
Q

Calcium carbonate toxicity

A

Hypercalcemia
rebound acid
can chelate and decrease effectiveness of other drugs like tetracycline

27
Q

List and describe MOA of the osmotic laxatives

A 
Provide osmotic load to draw out water
Magnesium hydroxide
Magnesium citrate
polyethylene glycol
lactulose
28
Q

In addition to being an osmotic laxative, Lactulose also:

what is the MOA of this action

A

treats hepatic encephalopathy

Gut flora metabolize it to lactic and acetic acid which binds NH3 to be excreted as NH4+

29
Q

Osmotic laxative toxicity and abuse

A

Diarrhea
dehydration
abuse by bullemics

30
Q

Infliximab MOA

A

Monoclonal AB to TNF-alpha

31
Q

Infliximab uses

A

Crohn’s
UC
RA

32
Q

Infliximab toxicity

A

Risk of infection–TB reactivation
Fever
HypoTn

33
Q

Sulfasalazine is a combination of

A

Sulfapyridine–a antibacterial

5-aminosalicylic acid–anti inflammatory

34
Q

Sulfasalazine has to be

A

activated by colonic bacteria

35
Q

Sulfasalazine uses and toxicity

A 
UC and Chrohn's
Malaise
nausea
sulfonamide toxicity?
reversible oligospermia
36
Q

Ondansteron MOa and toxicity

A

5-HT3 antagonist–central acting antiemetic

HA and constipation

37
Q

Ondansteron use

A

postoperative vomiting

chemotherapy vomiting

38
Q

Metoclopramide MOa

A

D2 receptor antagonist—increases resting tone, LES tone and motility
but no effect on colon transit time

39
Q

Metoclopramide use

A

DM and post-surg gastroparesis

antiemetic

40
Q

Metoclopramide toxicity

A

Increase parkinsonian effects
Restlessness/dizziness/fatigue/depression
N/D
drug interaction with digoxin and DM drugs

41
Q

Metoclopramide is contraindicated in

A

Small bowel obstruction

parkinson’s disease

Pharmacology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions