Repro Drugs

Question 1

Oestrogen action and side effects?

Answer 1

Endometrial proliferation
Increased blood coagulability

Breast tenderness
Thromboembolism

Breast, endometrial, ovarian cancer

Question 2

Progesterone action and side effects?

Answer 2

Maintains pregnancy
Fluid retention
Mood changes

Weight gain
Fluid retention
Acne
Depression

Question 3

Testosterone action and side effects?

Answer 3

Stimulate male secondary sexual characteristics

Acne
Male pattern baldness

Question 4

COCP?

Answer 4

Prevents ovulation (primary action)
Thickens cervical mucus

Question 5

POP?

Answer 5

Thickens cervical mucus (primary action)
Reduced cilia activity in fallopian tubes

Question 6

Which CYP enzyme metabolises COCP & POP?

Answer 6

CYP 450

Phenytoin/carbamazepine, St John’s wort induces metabolise of drug (CYP 450 inducers)

Question 7

HRT ADRs?

Answer 7

Oestrogen only - endometrial cancer

O & P - breast cancer

Both - ^VTE risk

Question 8

Bisphosphonates

Answer 8

For osteoporosis

Inhibit osteoclast formation

Question 9

Ulipristal Acetate (Ella One)

Answer 9

Selective Progesterone Receptor Modulator (SPRM)

Emergency contraception - inhibits ovulation by depressing LH surge

Question 10

Levonorgestrel

Answer 10

Progestogen

Stops ovulation

Question 11

Clomiphene

Answer 11

Selective Estrogen Receptor Modulator

Used for anovulation

Inhibits oestrogen negative feedback on hypothalamus

Question 12

Tamoxifen

Answer 12

Selective Estrogen Receptor Modulator (SERM)

Antagonist in breast - breast cancer
Prevents osteoporosis in bone
Induces ovulation
Antagonist in endometrium - endometrial cancer

Question 13

Mifepristone

Answer 13

Progesterone receptor antagonist

Termination of pregnancy