Anti-epileptic drugs? Flashcards
Benzodiazepines
Diazepam, Lorazepam, Midazalam
Potentate GABA activity at GABAa receptors
Na channel blockers
Carbamazepine, Phenytoin, Lamotrigine
Carbamazepine - trigeminal neuralgia too
Blocks Na channels so slows recovery of inactive neurones
Reduced Ca influx - reduced transmission
Na channel blockers DDIs, ADRs, Contraindications
Teratogenic
Bone marrow suppression
Hyponatraemia
CYP3A4 inducer - reduces COCP + warfarin effect
CYP3A4 inhibitor - carbamazepine (autoinduction of it’s own metabolism so need to ^dose over time)
Sodium Valproate - main ADR?
Na blocker
Teratogenic
Levetiracetam
SAFE IN PREGNANCY
Synaptic vesicle 2A Inhibition
Prevents Ca influx - neurotransmitter doesn’t get released
How long do you wait during a seizure before giving meds?
5 mins
Treatment steps for seizure?
- Lorazepam i.v. (benzodiazepine)
- Lorazepam i.v. (benzodiazepine)
- Phenytoin / Sodium Valproate