Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CPT Drugs > Antiemetics > Flashcards

Antiemetics Flashcards

You may prefer our related Brainscape-certified flashcards:
NASM ® CPT flashcards
1
Q

How do we vomit?

A
  1. Vomiting centre in medulla signals to vomit
  2. Take deep breath
  3. Glottis closes to protect airway
  4. Abdo muscles contract
  5. LOS relaxes
  6. Retrograde peristalsis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the 4 inputs to the Chemoreceptor trigger zone?

A

Vestibular nuclei - motion sickness
Visceral afferents from gut - bowel obstrction/GORD
Higher cortical centres - smells, pain, phobia
Direct triggers - chemo, srugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Muscuranic Antagonist - ADRs?

A

Hyoscine hydrobromide

MOTION SICKNESS

Blocks Ach Receptors in vestibular nuclei + CTZ

Sedation
Constipation
Dry mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

H1 Antagonist

A

Cyclizine
Levomepromazine (D2 antagonist too!)
Dihenhydramine (benadryl)

Inhibits histamenergic signals (H1) from vestibular nuclei to CTZ

Sedation
Anti-muscarinic ADRs (dry mouth, constipation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

5-HT3 Antagonist

A

Ondansetron

Inhibits CTZ centrally
Reduced GI motility peripherally
(serotonin - usually ^motility)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Domperidone - ADRs?

A

Central dopamine antagonist

Dry mouth
Galactorrhea
Long QT interval
Parkisonism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Metoclopramide - ADRs?

A

Central dopamine antagonist
Peripheral cholinergic agonist

^LOS tone / ^gastric contractions (^peristalsis)

Depression
Diarrhoea
Drowsiness
Galactorrhea (^prolactin)
Parkisonism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Anti-psychotic -ADRs?

A

Haloperidol

D2 receptor antagonist at CTZ

Parkinsonism
Long QT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

NK-1 Receptor Antagonist

A

Aprepitant

Delayed N+V (chemo)

Prevents excitatory action of substrate P

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Corticosteroids

A

Dexamethasone, Methylprednisolone

D2 antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cannaboids - ADRs?

A

Nabilone

Acts on CTZ

Depression/Psychosis
Drowsiness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Post op N+V?

A

Metoclopramide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pregnancy induced N+V?

A

Cyclizine (anti-histamine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

General N+V?

A

Ondansetron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Motion Sickness?

A

Hyoscine hydrobromide
Cyclizine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

^ICP N+V?

A

Haloperidol
(sedative too)

17
Q

Chemo induced N+V?

A

Ondansetron
Aprepitant (delayed)
Metoclopramide (delayed)

18
Q

Pre-med constipation?

A

High fibre
High fluid intake
Exercise

19
Q

Osmotic Laxatives?

A

Lactulose (draws fluid into bowel)

Macrogol (limits loss of fluid into bowel)

20
Q

Loperamide?

A

Mu receptor agonist in myenteric plexis
Increases segmental contractions
Reduces peristalsis

21
Q

Anti-diarrhoea?

A

Opioids - codeine
Mu receptor agonist

CPT Drugs (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions