Antibiotics Flashcards
Trimethoprim - DDI / X
UTI
Folate antagonist
Teratogenic
Methotrexate - both folate antagonists (myelosupression)
Nitrofurantoin - ADRs / X
UTI
Affects protein synthesis - 50% excreted in urine
Discolouration of urine
Pulmonary fibrosis
Pregnancy X
Aminoglycosides
Gentamicin, Vancomycin, Streptomycin
Septicaemia
Pneumonia
Otitis externa
Meningitis
Inhibit protein synthesis (bind to 30s)
Nephrotoxicity / Ototoxicity
Penicillins
Amoxicillin, Co-amoxiclav, Penicillin v, Flucloxacillin
Acute choleocystitis
Resp tract infections
Sinusitis
Inhibit cell wall synthesis
What is co-amoxiclav?
clavulanic acid is a B lactamase inhibitor
Macrolides
Clarithromycin, Erythromycin
Inhibit protein synthesis
Cephalosporins
Ceftriaxone, Cefalexin
Mengincoccal sepsis
Inhibits cell wall synthesis
Anti-viral
Aciclovir
Varicella zoster
Herpes simple virus
Inhibits viral DNA syntheisis