Diabetic Drugs

Question 1

How do you give insulin in type 1 diabetes ?

Answer 1

Basal Bolus dosing

Basal - Glargine (long acting)
Bolus - Aspart (fast acting)

Question 2

How do you treat DKA?

Answer 2

1. I.V. fluids
2. I.V. soluble insulin
3. K+ correction in additional fluids

Question 3

First line treatment for type II DM?

Answer 3

Weight loss

Question 4

Biguanides

Answer 4

Metformin

Inhibits gluconeogenesis in liver

Question 5

Gliflozins

Answer 5

Dapagliflozin, Canagliflozin, Empagliflozin

Reversibly inhibit Na-glucose co-transporter at PCT

Question 6

Sulfonyulreas

Answer 6

Glicazide

Stimulates B-cell pancreatic insulin

Question 7

Glitazones

Answer 7

Pioglitazone, rosiglitazone

PPARy Receptor agonist - reduced hepatic glucose output

Question 8

Gliptins

Answer 8

Sitagliptin

DDP-4 inhibitors - ^plasma incretin levels

Question 9

GLP 1 Receptor Agonists

Answer 9

Exenatide, Liraglutide, Semaglutide

Stimulates glucose dependent insulin secretion
Promotes satiety

Question 10

What can you do if a patient is struggling with GI upset on metformin?

Answer 10

Give them modified release Metformin
(digested less quickly)