Hyperlipidaemia Flashcards
1
Q
Statins
A
Atorvastatin, Simvastatin
Competitive inhibition of HMG-CoA reductase
2
Q
Non lipid-lowering benefits of statins?
A
Antioxidant
Anti inflammatory
Plaque stabilisation
Improved haemostasis
3
Q
Cholesterol Absorption Inhibitors
A
Ezetimibe
Inhibits NPC1L1 transporter at brush border - reducing gut cholesterol absorption
4
Q
Fibrates
A
Fenofibrate
Activates nuclear transcription factor PPARa - ^HDL levels
5
Q
PCSK9 Inhibitor
A
Alirocumab, Evolocumab
Familial hypercholesterolaemia
Bind to PCSK9 to prevent binding of LDL receptors
6
Q
Non - med lipid lowering methods
A
Oily fish
Fibre
Plant sterols
Vit C & E
