Repro Flashcards
Molluscum Contagiosum Virus
- DNA poxvirus
- cytoplasmic viral inclusion
Extramammary Paget Disease of Vulva
- crusting, red lesions of vulva
- intradermal malignant cells
- not usually associated with underlying tumor
- PAS+
Diethylstilbestrol (DES) in utero causes?
-adenosis that can progress to clear cell adenocarcinoma of vagina
Embryonal Rhabdomyosarcoma
- grapelike mass coming out of vagina of young girl
- spindle shaped tumor cells with cross striations
- positive for desmin and MyoD1 (muscle markers)
Gartner Duct Cyst
-cyst of lateral wall of vagina due to persistance of mesonephric (Wolffian) duct
Mullerian Agenesis Causes:
- no formation of upper 1/3 of vagina, uterus, or fallopian tubes
- do have eggs
Fitz Hugh Curtis Syndrome
- PID with R upper quad pain
- infection spread to liver (perihepatitis)
- violin string adhesions
Most Deadly Lower Female Cancer
-ovarian
Most Common Lower Female Cancer
-Endometrial cancer
HPV E6 binds?
p53
HPV E7 binds?
Rb
Chocolate Cysts mean?
- Endometriosis
- also gun shot or powder burn lesions
Leiomyoma
- fibroid
- benign
- estrogen dependent
- can cause spontaneous abortion
- well circumscribed
- repro age women
- trabeculated, whorled
PTEN Mutation
-endometrial adenocarcinoma
PCOS
- signs of androgen excess, oligoovulation, polycystic ovaries (need 2 out of 3 to dx)
- inc. LH, dec. FSH, inc. T, inc. E
- at risk for endometrial cancer due to inc. E
Types of surface epithelial cell tumors of ovary?
- Pseudomycomaperitinii (jelly belly)
- serous tumor
- mucinous tumor
- endometrioid tumor
- clear cell tumor
- brenner tumor (transitional epithelium, ie bladder)
Types of germ cell tumors of ovary?
- teratoma
- dysgerminoma (seminoma in men)
- endodermal sinus tumor
- choriocarcinoma
Types of tumors of sex cord stroma in ovary?
- fibroma
- granulosa-theca cells tumor
- sertoli-leydig tumor
CA125
-tumor marker for ovarian cancer
Struma Ovarii
-special name for teratoma that has mostly thyroid tissue that can cause thyroid disease
Dysgerminomna
- associated with streak ovaries due to Turners
- seminoma in men (due to streak gonads in Klinefelters)
- sensitive to radiation
Meigs Syndrome
- refers to combo of fibroma (sex cord stromal tumor), ascites, and pleural effusion
- don’t confuse with deadly papillary serous tumor
Granulosa Cell Tumor
- estrogen producing tumor
- early puberty, mess up period cycle
- can cause endometrial hyperplasia and cancer
- call-exner bodies (think who ya gonna call? Ghostbusters!)
Sertoli Leydig Cell Tumor
- androgen producing tumor
- can affect fetus and cause virulization of female fetus in affected mother
Complete Mole
- completely from dad
- tumor of placental trophoblastic tissue
- 46 chromosomes
- more likely to have choriocarcinoma
Partial Mole
- normal egg fertilized by two sperm
- part fetus
- snow storm on US
- elevated bHCG
- may be grape like structures coming out of vagina
- edematous chorionic villi
- check bHCG to make sure it goes down (if still up means choriocarcinoma)
- 69 chromosomes
Choriocarcinoma is tumor of?
-placenta
Things that cause calcifications in breast?
- fat necrosis
- carcinoma
Most common benign tumor of breast?
-fibroadenoma
Intraductal Papilloma
-presents with bloody nipple discharge
-benign
-
What function to BRCA1 and 2 have?
-error free repair of DNA double stranded breaks
When do we see peau d’orange?
- inflammatory carcinoma
- poor prognosis
Pagets Disease of Nipple
-underlying invasive or in situ ductal carcinoma that comes out of nipple
What structure is proliferating in gynecomastia? Ducts, lobules, or both?
- Men don’t have lobules
- Men have ducts, so this is what proliferates in gynecomastia
Epispadias issue
-tubercle formation problem
Hypospadias Problem
-urethral fold closure issue
What anemia is associated with priapism?
- erection that doesn’t go away
- associated with sickle cell anemia
What is patent with hydrocele?
-processus vaginalis
AFP
-produced by yolk sac tumor (made in fetal liver)
B HCG
-produced by choriocarcinoma (syncytiotrophoblast)
Yolk Sac Tumor of Testes
- common in kids
- also called endodermal sinus tumor
- schiller duval bodies
- AFP
Schiller Duval?
-yolk sac tumor of testes
Reinke Crystals
-marker for leydig cell tumors
What cancer do you get if you are a chimney sweep?
-scrotal squamous cell carcinoma
5 alpha reductase
converts T to DHT
-ex. finasteride is 5 a reductase inhibitor of prostate hyperplasia
Chadwick’s Sign
- blue tinged vaginal mucosa
- due to inc. blood flow in early pregnancy
What cells secrete bHCG from the placenta?
-syncitiotrophoblasts
What bug is involved in septic abortion?
- staph aureus
- gram neg bacilli (e. coli)
