- fibroid - benign - estrogen dependent - can cause spontaneous abortion - well circumscribed - repro age women - trabeculated, whorled

- signs of androgen excess, oligoovulation, polycystic ovaries (need 2 out of 3 to dx) - inc. LH, dec. FSH, inc. T, inc. E - at risk for endometrial cancer due to inc. E

Repro Flashcards by Danielle Eves

Molluscum Contagiosum Virus

DNA poxvirus

- cytoplasmic viral inclusion

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Extramammary Paget Disease of Vulva

crusting, red lesions of vulva
intradermal malignant cells
not usually associated with underlying tumor
PAS+

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Diethylstilbestrol (DES) in utero causes?

-adenosis that can progress to clear cell adenocarcinoma of vagina

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Embryonal Rhabdomyosarcoma

grapelike mass coming out of vagina of young girl
spindle shaped tumor cells with cross striations
positive for desmin and MyoD1 (muscle markers)

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Gartner Duct Cyst

-cyst of lateral wall of vagina due to persistance of mesonephric (Wolffian) duct

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Mullerian Agenesis Causes:

no formation of upper 1/3 of vagina, uterus, or fallopian tubes
do have eggs

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Fitz Hugh Curtis Syndrome

PID with R upper quad pain
infection spread to liver (perihepatitis)
violin string adhesions

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Most Deadly Lower Female Cancer

-ovarian

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Most Common Lower Female Cancer

-Endometrial cancer

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HPV E6 binds?

p53

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HPV E7 binds?

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Chocolate Cysts mean?

Endometriosis

- also gun shot or powder burn lesions

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Leiomyoma

fibroid
benign
estrogen dependent
can cause spontaneous abortion
well circumscribed
repro age women
trabeculated, whorled

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PTEN Mutation

-endometrial adenocarcinoma

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PCOS

signs of androgen excess, oligoovulation, polycystic ovaries (need 2 out of 3 to dx)
inc. LH, dec. FSH, inc. T, inc. E
at risk for endometrial cancer due to inc. E

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Types of surface epithelial cell tumors of ovary?

Pseudomycomaperitinii (jelly belly)
serous tumor
mucinous tumor
endometrioid tumor
clear cell tumor
brenner tumor (transitional epithelium, ie bladder)

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Types of germ cell tumors of ovary?

teratoma
dysgerminoma (seminoma in men)
endodermal sinus tumor
choriocarcinoma

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Types of tumors of sex cord stroma in ovary?

fibroma
granulosa-theca cells tumor
sertoli-leydig tumor

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CA125

-tumor marker for ovarian cancer

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Struma Ovarii

-special name for teratoma that has mostly thyroid tissue that can cause thyroid disease

Dysgerminomna

associated with streak ovaries due to Turners
seminoma in men (due to streak gonads in Klinefelters)
sensitive to radiation

Meigs Syndrome

refers to combo of fibroma (sex cord stromal tumor), ascites, and pleural effusion
don’t confuse with deadly papillary serous tumor

Granulosa Cell Tumor

estrogen producing tumor
early puberty, mess up period cycle
can cause endometrial hyperplasia and cancer
call-exner bodies (think who ya gonna call? Ghostbusters!)

Sertoli Leydig Cell Tumor

androgen producing tumor

- can affect fetus and cause virulization of female fetus in affected mother

Complete Mole

- completely from dad - tumor of placental trophoblastic tissue - 46 chromosomes - more likely to have choriocarcinoma

Partial Mole

- normal egg fertilized by two sperm - part fetus - snow storm on US - elevated bHCG - may be grape like structures coming out of vagina - edematous chorionic villi - check bHCG to make sure it goes down (if still up means choriocarcinoma) - 69 chromosomes

Choriocarcinoma is tumor of?

-placenta

Things that cause calcifications in breast?

- fat necrosis | - carcinoma

Most common benign tumor of breast?

-fibroadenoma

Intraductal Papilloma

-presents with bloody nipple discharge -benign -

What function to BRCA1 and 2 have?

-error free repair of DNA double stranded breaks

When do we see peau d'orange?

- inflammatory carcinoma | - poor prognosis

Pagets Disease of Nipple

-underlying invasive or in situ ductal carcinoma that comes out of nipple

What structure is proliferating in gynecomastia? Ducts, lobules, or both?

- Men don't have lobules | - Men have ducts, so this is what proliferates in gynecomastia

Epispadias issue

-tubercle formation problem

Hypospadias Problem

-urethral fold closure issue

What anemia is associated with priapism?

- erection that doesn't go away | - associated with sickle cell anemia

What is patent with hydrocele?

-processus vaginalis

AFP

-produced by yolk sac tumor (made in fetal liver)

B HCG

-produced by choriocarcinoma (syncytiotrophoblast)

Yolk Sac Tumor of Testes

- common in kids - also called endodermal sinus tumor - schiller duval bodies - AFP

Schiller Duval?

-yolk sac tumor of testes

Reinke Crystals

-marker for leydig cell tumors

What cancer do you get if you are a chimney sweep?

-scrotal squamous cell carcinoma

5 alpha reductase

converts T to DHT | -ex. finasteride is 5 a reductase inhibitor of prostate hyperplasia

Chadwick's Sign

- blue tinged vaginal mucosa | - due to inc. blood flow in early pregnancy

What cells secrete bHCG from the placenta?

-syncitiotrophoblasts

What bug is involved in septic abortion?

- staph aureus | - gram neg bacilli (e. coli)