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Repro Flashcards

1
Q

Molluscum Contagiosum Virus

A
  • DNA poxvirus

- cytoplasmic viral inclusion

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2
Q

Extramammary Paget Disease of Vulva

A
  • crusting, red lesions of vulva
  • intradermal malignant cells
  • not usually associated with underlying tumor
  • PAS+
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3
Q

Diethylstilbestrol (DES) in utero causes?

A

-adenosis that can progress to clear cell adenocarcinoma of vagina

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4
Q

Embryonal Rhabdomyosarcoma

A
  • grapelike mass coming out of vagina of young girl
  • spindle shaped tumor cells with cross striations
  • positive for desmin and MyoD1 (muscle markers)
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5
Q

Gartner Duct Cyst

A

-cyst of lateral wall of vagina due to persistance of mesonephric (Wolffian) duct

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6
Q

Mullerian Agenesis Causes:

A
  • no formation of upper 1/3 of vagina, uterus, or fallopian tubes
  • do have eggs
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7
Q

Fitz Hugh Curtis Syndrome

A
  • PID with R upper quad pain
  • infection spread to liver (perihepatitis)
  • violin string adhesions
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8
Q

Most Deadly Lower Female Cancer

A

-ovarian

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9
Q

Most Common Lower Female Cancer

A

-Endometrial cancer

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10
Q

HPV E6 binds?

A

p53

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11
Q

HPV E7 binds?

A

Rb

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12
Q

Chocolate Cysts mean?

A
  • Endometriosis

- also gun shot or powder burn lesions

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13
Q

Leiomyoma

A
  • fibroid
  • benign
  • estrogen dependent
  • can cause spontaneous abortion
  • well circumscribed
  • repro age women
  • trabeculated, whorled
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14
Q

PTEN Mutation

A

-endometrial adenocarcinoma

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15
Q

PCOS

A
  • signs of androgen excess, oligoovulation, polycystic ovaries (need 2 out of 3 to dx)
  • inc. LH, dec. FSH, inc. T, inc. E
  • at risk for endometrial cancer due to inc. E
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16
Q

Types of surface epithelial cell tumors of ovary?

A
  • Pseudomycomaperitinii (jelly belly)
  • serous tumor
  • mucinous tumor
  • endometrioid tumor
  • clear cell tumor
  • brenner tumor (transitional epithelium, ie bladder)
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17
Q

Types of germ cell tumors of ovary?

A
  • teratoma
  • dysgerminoma (seminoma in men)
  • endodermal sinus tumor
  • choriocarcinoma
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18
Q

Types of tumors of sex cord stroma in ovary?

A
  • fibroma
  • granulosa-theca cells tumor
  • sertoli-leydig tumor
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19
Q

CA125

A

-tumor marker for ovarian cancer

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20
Q

Struma Ovarii

A

-special name for teratoma that has mostly thyroid tissue that can cause thyroid disease

21
Q

Dysgerminomna

A
  • associated with streak ovaries due to Turners
  • seminoma in men (due to streak gonads in Klinefelters)
  • sensitive to radiation
22
Q

Meigs Syndrome

A
  • refers to combo of fibroma (sex cord stromal tumor), ascites, and pleural effusion
  • don’t confuse with deadly papillary serous tumor
23
Q

Granulosa Cell Tumor

A
  • estrogen producing tumor
  • early puberty, mess up period cycle
  • can cause endometrial hyperplasia and cancer
  • call-exner bodies (think who ya gonna call? Ghostbusters!)
24
Q

Sertoli Leydig Cell Tumor

A
  • androgen producing tumor

- can affect fetus and cause virulization of female fetus in affected mother

25
Q

Complete Mole

A
  • completely from dad
  • tumor of placental trophoblastic tissue
  • 46 chromosomes
  • more likely to have choriocarcinoma
26
Q

Partial Mole

A
  • normal egg fertilized by two sperm
  • part fetus
  • snow storm on US
  • elevated bHCG
  • may be grape like structures coming out of vagina
  • edematous chorionic villi
  • check bHCG to make sure it goes down (if still up means choriocarcinoma)
  • 69 chromosomes
27
Q

Choriocarcinoma is tumor of?

A

-placenta

28
Q

Things that cause calcifications in breast?

A
  • fat necrosis

- carcinoma

29
Q

Most common benign tumor of breast?

A

-fibroadenoma

30
Q

Intraductal Papilloma

A

-presents with bloody nipple discharge
-benign
-

31
Q

What function to BRCA1 and 2 have?

A

-error free repair of DNA double stranded breaks

32
Q

When do we see peau d’orange?

A
  • inflammatory carcinoma

- poor prognosis

33
Q

Pagets Disease of Nipple

A

-underlying invasive or in situ ductal carcinoma that comes out of nipple

34
Q

What structure is proliferating in gynecomastia? Ducts, lobules, or both?

A
  • Men don’t have lobules

- Men have ducts, so this is what proliferates in gynecomastia

35
Q

Epispadias issue

A

-tubercle formation problem

36
Q

Hypospadias Problem

A

-urethral fold closure issue

37
Q

What anemia is associated with priapism?

A
  • erection that doesn’t go away

- associated with sickle cell anemia

38
Q

What is patent with hydrocele?

A

-processus vaginalis

39
Q

AFP

A

-produced by yolk sac tumor (made in fetal liver)

40
Q

B HCG

A

-produced by choriocarcinoma (syncytiotrophoblast)

41
Q

Yolk Sac Tumor of Testes

A
  • common in kids
  • also called endodermal sinus tumor
  • schiller duval bodies
  • AFP
42
Q

Schiller Duval?

A

-yolk sac tumor of testes

43
Q

Reinke Crystals

A

-marker for leydig cell tumors

44
Q

What cancer do you get if you are a chimney sweep?

A

-scrotal squamous cell carcinoma

45
Q

5 alpha reductase

A

converts T to DHT

-ex. finasteride is 5 a reductase inhibitor of prostate hyperplasia

46
Q

Chadwick’s Sign

A
  • blue tinged vaginal mucosa

- due to inc. blood flow in early pregnancy

47
Q

What cells secrete bHCG from the placenta?

A

-syncitiotrophoblasts

48
Q

What bug is involved in septic abortion?

A
  • staph aureus

- gram neg bacilli (e. coli)

Step 1 (23 decks)

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