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DT3 Exam 2 > Renal Vascular disease > Flashcards

Renal Vascular disease Flashcards

1
Q

What does benign nephrosclerosis effect

A

medial and intimal thickening due to hyaline deposition

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2
Q

What is a granular appearance on the outside of a kidney most likely?

A

benign nephrosclerosis

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3
Q

Who is at risk of Benign Nephrosclerosis causing renal insufficiency

A

African descent

severe hypertension

underlying disease (diabetes)

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4
Q

What is the gross appearance of the kidney in malignant hypertension

A

“flea bitten” from petechial hemorrhages

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5
Q

Histology of malignant nephrosclerosis?

A

fibrinoid necrosis

hyperplastic arteriolosclerosis

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6
Q

Unilateral renal artery stenosis causes?

A

Renin release which leads to ATII release

This causes HTN due to aldosterone holding Na and H2O

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7
Q

What is most likely to cause Renal artery stenosis in men and women

A

Men-atherosclerotic plaque

women- fibromuscular dysplasia

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8
Q

What do you see in unilateral renal artery stenosis

A

Affected kidney has heightened renin levels

Opposite kidney has hyaline arteriolosclerosis

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9
Q

If you have normal renal function with hyalinized glomeruli and fibrosis and thickening, what is the diagnosis?

A

benign nephrosclerosis

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10
Q

HUS results from

A

endothelial injury leading to platelet aggregation and thrombosis

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11
Q

What happens in typical HUS

A

Shiga-like toxin causes injury

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12
Q

What happens in atypical HUS

A

excessive activiation of complement rom mutations

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13
Q

What causes TTP

A

platelet aggregation from multimers of vWF

due to deficiency of ADAMTS13 metalloprotease

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14
Q

What causes HUS

A

E.coli 0157-H7

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15
Q

What can cause atypical HUS

A

anti-phospholipid Ab syndrome

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16
Q

Pentad of TTP

A 
Fever
Renal failure
Hemolytic anemia
Thrombocytopenia
Neurologic (dominant feature)
17
Q

What is atherosclerotic ischemic renal disease

A

bilateral renal artery disease

chronic ischemia

18
Q

What is atheroembolic renal disease caused by

A

Intervention in an area with a plaque (ie AAA, Aortic valve angioplasty)

19
Q

What is a cholesterol emboli

A

Clear clefts in vessel

20
Q

What is injured if there is impaired concentrating ability

A

Tubules

21
Q

What follows catastrophic conditions in the kidney that is uncommon

A

diffuse cortical necrosis

ex) abruptio placentae, septic shock

DT3 Exam 2 (18 decks)

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