(25) restrictive Flashcards
Which way does the shift occur in restricitive lung disease
Left
FEV/FVC in restrictive?
Increased
What do you see in Idiopathic Pulm Fibrosis
Usual Interstitial Pneumonia histology
Buzzword for IPF
honeycomb lungs
Microscopic IPF
microscopic honeycomning
fibroblast foci
Coal workers pneumoconiosis location
Upper lungs
What is Caplan syndrome
Coal workern pnemo
Rheumatoid arthritis
Who gets silicosis
mining
foundry
stell worker
sandblasting
What does silica do
causes oxygen radical formation which leads to IL-1 and necrosis
What has egg shell calcification
Silicosis
Histology of silicosis
Hyalinized collagen concentric
Who gets berrylosis
aerospace
What happens in berryilosis
Th1 response that invovled interferon gamma and IL-2
What gene is in berryilosis
HLA-DPB1
What is seen in berryilosis
non caseating granulomas
What do you see pleural plaques in
Asbestosis
What does asbestosis have in it
asbestos bodies (iron)
Where is asbestosis located
lower lung/periphery
What is seen in sarcoidosis
non caseating granuloma
upper lobes
skin/joint/eye lesions
What causes sarcoidosis
Macophage and dendritic activation that make giant cells.
IL2 and IL15
Inf gamma
IL6 and IL8
Microscopic sarcoidosis
Well formed granuloma
Asteroid body
Schaumann body
calcium oxalate crystals
What do you see in hypersensitivity pneumonitis
ground glass appearance
Restrictive disease on DLCO
DLCO decreased
