(21) Interstitial and occup resp Flashcards by Taylor Spry | Brainscape

Q

Who gets sarcoidosis

A

African americans

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Q

What is a granuloma

A

histiocytes/macrophages

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Q

Sarcoidosis has increased

A

CD4
IL2
Int gamma

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Q

What type of granuloma does sarcoidosis have

A

noncaseating granulomas

NO NECROSIS

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Q

What do you see in sarcoidosis

A

Langhans

Schumann bodies

Asteroid bodies

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Q

What is involved in sarcoidosis (7)

A

Lungs

hilar lymphadenopathy

interstitial fibrosis

large spleen

liver granuloma

hands and feet

skin and eyes

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Q

Sarcoidosis clinical

A

dyspnea/cough (hemoptysis)

fatigure/fever/weight loss

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Q

What is hypersensitivity pneumonitis

A

immunologically mediated process to antigen

TYPE III rxn (maybe IV too)

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Q

Farmers lun

A

inhaled spores of actinomycetes

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Q

Pigeon breeder lungs

A

inhaled proteins from feathers

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Q

Humidifier lung

A

thermophilic bacteria

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Q

What is formed in hypersensitivity pneumonitis

A

non-necrotizing granulomas that are not well formed

honeycombing

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Q

Acute eosinophilia pneumonia

A

rapid onset

> 25% eosinophils

coricosteroids repsonse

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Q

Simple pulmonary eosinophilia

A

food and drugs

transient lung lesion and blood eosinophilia

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Q

Secondary pulmonary eosinophilia

A

parasitic, bacterial, fungal

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Q

Chronic eosinophilic pneumonia

A

autoimmune RA

lymphocytic and eosinophilic

Steroid therapy

Q

Desquamative interstital pnemonitits

A

Macrophages with brown pigment

Q

Who gets Desquamative interstital pnemonitits

A

4th/5th decade men smokers

Q

cell type in Desquamative interstital pnemonitits

A

histiocytes

Q

Treat DIP

A

steroids and stop smoking

Q

Pulmonary Alveolar Proteinosis

A

aquires

granulocyte macrophage colony stimularing factor

GM-CSF antibodies

causes surfactacnt clearance issues

Q

Pulmonary Alveolar Proteinosis morphology

A

heavy lungs

PAS positive w/cholesterol clefts

Q

Pulmonary Alveolar Proteinosis clinical

A

couch with gelatinous material

lavage used to ttreat

Q

surfactant deficiencies

A

protein C and B

ATP binding ABCA