(21) Interstitial and occup resp Flashcards
Who gets sarcoidosis
African americans
What is a granuloma
histiocytes/macrophages
Sarcoidosis has increased
CD4
IL2
Int gamma
What type of granuloma does sarcoidosis have
noncaseating granulomas
NO NECROSIS
What do you see in sarcoidosis
Langhans
Schumann bodies
Asteroid bodies
What is involved in sarcoidosis (7)
Lungs
hilar lymphadenopathy
interstitial fibrosis
large spleen
liver granuloma
hands and feet
skin and eyes
Sarcoidosis clinical
dyspnea/cough (hemoptysis)
fatigure/fever/weight loss
What is hypersensitivity pneumonitis
immunologically mediated process to antigen
TYPE III rxn (maybe IV too)
Farmers lun
inhaled spores of actinomycetes
Pigeon breeder lungs
inhaled proteins from feathers
Humidifier lung
thermophilic bacteria
What is formed in hypersensitivity pneumonitis
non-necrotizing granulomas that are not well formed
honeycombing
Acute eosinophilia pneumonia
rapid onset
> 25% eosinophils
coricosteroids repsonse
Simple pulmonary eosinophilia
food and drugs
transient lung lesion and blood eosinophilia
Secondary pulmonary eosinophilia
parasitic, bacterial, fungal
Chronic eosinophilic pneumonia
autoimmune RA
lymphocytic and eosinophilic
Steroid therapy
Desquamative interstital pnemonitits
Macrophages with brown pigment
Who gets Desquamative interstital pnemonitits
4th/5th decade men smokers
cell type in Desquamative interstital pnemonitits
histiocytes
Treat DIP
steroids and stop smoking
Pulmonary Alveolar Proteinosis
aquires
granulocyte macrophage colony stimularing factor
GM-CSF antibodies
causes surfactacnt clearance issues
Pulmonary Alveolar Proteinosis morphology
heavy lungs
PAS positive w/cholesterol clefts
Pulmonary Alveolar Proteinosis clinical
couch with gelatinous material
lavage used to ttreat
surfactant deficiencies
protein C and B
ATP binding ABCA
