(22) respiratory viral Flashcards
How does infection start in respiratory virus
epithelial cell receptor attachment
Paramyxoviridae structure
SS RNA -
has RNAdep RNA polyerase
envelope w/ spikes
Paramyxoviridae glycoproteins
Hemagglutinin
Neruaminidase
Fusion protein
Paramyxoviruses glycoproteins
HN, F
Morbilliviruses glycoproteins
H, F
RSV glycoproteins
F
What does F do
mediates fusion between virus and cell membrane
Patamyxoviridae replication site
cytoplasmic
Parainfluenza type kids get first then following order
3, 1, 2, 4
what % for herd immunity
96%
What causes pneumoviridae
RSV then parainf 3, 1,2,4
immune complex IgA in children
what has to happen to hemagluttinin
must be cleaved to be active
What is antigenic drift
epidemics
What is antigenic shift
Pandemics. mix of 2 viruses
what helps with mucus in viruses
Neuraminidase
Influ type B
younger
No aspirin bc Reye syndrome
Guillain burre
What blocks uncoating
amantidine and rimantadine
What inhibits viral RNA synthesis
Ribavirin
What blocks neuraminidase
Zanamivir
Peramivir
Oseltamivir
prevent budding
What prevents cleavage of cell cap
Baloxavir
Marboxil
What is IIV
inactivated influenza
Fluzone?
high dose for old ppl
Flublock vaccine
18 and up H isolated
What makes IgA and IgG
Intranasal vaccine
Rhinovirus setup
ss RNA +
Coccacies A and B
Echo
cold rinitis
Rhinoviruses are
acid labile
What do rhinoviruses cause
mostly upper respiratory viruses
Coronaviridae structure
helical
SS RNA +
envelope (PEPLOMERS)
What does SARS cause
upper and lower respiratory tract
how did corona virus start
fish market to yuumans
