Renal Embryology Flashcards
What plate of mesoderm gives rise to the urogenital system?
Intermediate plate of mesoderm
What are the two ridges that give rise to the renal, then genital regions?
Renal: Nephrogenic ridge
Genital: Genital ridge
What are the three developmental phases make up the intermediate mesoderm?
Pronephros
Mesonephros
Metanephros
What happens in the pronephric phase?
Pronephric duct grows toward cloaca
What does the pronephric duct become?
Mesonephric (Wolffian duct)
What happens in the mesonephric phase?
Pronephric duct becomes mesonephric duct
What do the mesonephric tubules become?
Efferent ductules of male testis
What does the mesonephric duct become?
Ductus deferens and ureteric bud in male
Ureteric bud in female
_____ grows into the _________ and forms the _______
Ureteric bud
Intermediate mesoderm
Metanephros (permanent kidney)
What structures does the ureteric bud make?
Collecting ducts (tubules)
Major and minor calyces
Renal pelvis
Ureter
What embryological tissue gives rise to nephrons?
Metanephric blastema
What embryological tissue gives rise to the collecting ducts?
Uretary buds
How many vascular lobes are originally supplied by segmental vessels?
Five
Where do kidneys get vascular supply from initially?
Common iliac arteries
What developmental abnormality results from failure of ureteric bud and metanephric mesoderm interaction?
Renal agenesis
Who is most common to get renal agenesis?
Males
What obstetric abnormality can tip off a physician to renal agenesis?
Single umbilical artery
What developmental abnormalities result from partial division of the ureteric bud prior to interaction with metanephric mesoderm?
Bifid ureters
What developmental abnormalities result from complete division of the ureteric bud prior to interaction with metanephric mesoderm?
Supernumary kidneys
Abnormal or non-rotation
What developmental abnormality can result from failure of metanephric kidney migration from pelvis?
Pelvic kidney (fused)
What developmental abnormalities can result from one developing kidney migrating to the contralateral side?
Crossed ectopic kidney
Fused kidneys
Malrotation
What developmental abnormality can result from fusion of the inferior poles of the kidney?
Horseshoe kidney
What does a horseshoe kidney ascent oftentimes get blocked by?
Inferior mesenteric artery
What is a potential complication of a polar renal artery?
Hydronephrosis
What is dilated in the multicystic dysplastic kidney disease?
Nephrons, usually thin segments
What does the site of fusion of the cloacal membrane and urorectal septum form?
Perineal body
What does the allantois become?
urachus
