Pancreatic Islet Histology Flashcards
1
Q
Where are the islet cells most concentrated in the pancreas?
A
More in tail
2
Q
What are the four important islet cells for Dr. Downing and what do they secrete?
A
Alpha cells (glucagon) Beta cells (insulin) Delta cells (somatostatin) PP or F cells (pancreatic polypeptide)
3
Q
What is the abundance of cells in the pancreas in descending order?
A
Beta 70%
Alpha 20%
Delta <10%
PP/F ~1%
4
Q
What is the purpose of alpha cells?
A
glucagon to raise blood sugar
5
Q
What is the purpose of beta cells?
A
insulin to decrease blood sugar and increase protein
6
Q
What is the purpose of delta cells?
A
Somatostatin to suppress A and B cells via paracrine
Reduce alimentary tract/gall bladder smooth muscle contraction via endocrine
7
Q
What is the purpose of PP cells?
A
Inhibit enzymatic secretion from exocrine pancreas
Relaxes gall bladder resulting in decreased bile secretion
