Renal Cancer: Renal Cell Carcinoma Flashcards
1
Q
renal cell carcinoma
A
- 2:1 prevalence in men than women
- mean age median = 60 yrs old
- rare before 50 yrs old
- mostly in upper pole
- largely silent
2
Q
risk factors
A
- smoking
- HTN
- obesity r/t altered metabolism, no direct link
- PKD
3
Q
PKD
A
- polycystic kidney disease
- development of acquired cysts
- 2 forms: genetic and non-genetic
4
Q
forms
A
- 4 cellular forms with different genetics
- clear cell carcinoma (70-80%); most prevalent form
- 3 remaining forms make up 20-25% of renal cell carcinoma
- clear cell refers to cytoplasm
5
Q
origin
A
- proximal tubular epithelial cells
6
Q
chromosome affected
A
chromosome 3 (deletion)
7
Q
manifestations
A
hematuria, flank mass and pain (10%)
8
Q
diagnosis
A
US, CT
9
Q
treatment
A
- radical nephrectomy and lymph node removal
- 5 year survival: 90% if mass is in kidney, 20% if mets
