Glomerular Disease

Question 1

glomerulus

Answer 1

• capillary network in Bowman’s capsule
• 2 processes: ultrafiltration and reabsorption
• alternation in permb of glomerulus will result in more or less components being filtered out of the blood and into the urine

increased permb = more components filtered out (increased urine output)

decreased permb = less components filtered out (decreased fluid output, fluid retention)

Question 2

5 clinical presentations

Answer 2

1. Acute Nephritic Syndromes
2. Nephrotic Syndromes
3. Asymptomatic Proteinuria and Hematuria
4. Acute Glomerulonephritis
5. Chronic Glomerulonephritis

Question 3

acute nephritic syndromes

Answer 3

• decreased glomerular permb (decreased GFR) -> retain fluids (water and electrolytes) and nitrogenous wastes
• complx = azotemia, edema, HTN

Question 4

nephrotic syndromes

Answer 4

• increased glomerular permb (increased GFR) -> lose components in urine that shouldn’t be excreted (proteins, cells)
• increased proteinuria and hypoalbuminemia
• hyperlipidemia r/t liver responding to hypoalbuminemia by prod. more proteins, and at same time prod increased LDLs -> lipiduria d/t increased lipids in circulation

Question 5

asymptomatic proteinuria and hematuria

Answer 5

• no impairment of kidney fx (GFR is normal)

- far less proteinuria than in nephrotic syndromes (less severe)

Question 6

glomerular disease

Answer 6

immune based disease where:

• Abs react with fixed antigens or
• circulating ICs lodge in the glomerulus

Question 7

manifestations

Answer 7

can have a mix of mnftns of the 5 categories