Renal Flashcards
nephrotic- range proteinuria, thickened basement membrane, basement membrane spikes, subepithelial domes
membranous nephropathy
“train track” basement membrane, subendothelial humps, mesangial cell proliferation, hepatitis B
membranoproliferative GN
subepithelial humps, decreased C3 levels, Coca-Cola urine, positive anti-DNAse B titer
post-streptococcal GN
may occur after URI, HSP, AKA Berger disease, mesangial deposits of IgA
IgA glomerulonephropathy
protein deposits in the heart, liver, and kidney, associated with multiple myeloma, apple green birefringence
amyloidosis
defect in Type IV collagen, cataracts, nephritis, high- frequency hearing loss
Alport syndrome (type IV collagen)
diffuse proliferative GN, anti-dsDNA antibodies, “wire loop” basement membranes
lupus nephritis
microscopic hematuria, pulmonary infiltrates, anti-GBM antibodies
Goodpasture syndrome
hematuria and proteinuria, pulmonary infiltrates, nasopharyngeal granulomas, c-ANCA
granulomatosis with polyangiitis (Wegener’s)
proteinuria and edema, podocyte foot process effacement, most common cause of nephrotic syndrome in children, treat with corticosteroids
minimal change disease
common cause of nephrotic syndrome in HIV patients, common cause of nephrotic syndrome in Blacks, common cause of nephrotic syndrome in latinos, most common cause of nephrotic syndrome in US adults
focal segmental glomerulosclerosis
nephrotic syndrome
proteinuria >3.5g/24hrs
hypoalbuminemia
peripheral edema
multiple mesangial nodules
kimmelstein wilson nodules of diabetic nephropathy
MC nephrotic syndrome in children
minimal change disease
MC nephrotic syndrome in adults
focal segmental glomerulosclerosis
