Renal

Question 1

Nephrotic range proteinuria in Minimal change disease

Answer 1

Antinephrin autoantibodies in podocytes

Question 2

Renal disease

Answer 2

Ciliopathies cystic kidney disease
Podocytopathies nephrotic syndrome/ FSGS
Basement membrane Alpert’s
Tubulopathies
Complement atypical HUS

Question 3

KIDGO
Increase > 0.3 mg/dl within 48 hrs
Or > 50-99% rise from baseline within 7 days
Urine output: <0.5 ml/kg/h for > 6hr

Question 4

Nephrotic range proteinuria

Answer 4

1. Minimal disease
2. Membranous nephropathy
3. Focal segmental glomerulodclerosid
4. Lupus membranous nephropathy

Question 5

Minimal change

Answer 5

Antinephrin antibody causing glomerular permeability factor targeting filtration barriers

Question 6

Membranous nephropathy
(Thick basement membrane)

Answer 6

Autoaby against phospholipase A2 receptor on podocytes
(If neural epidermal growth factor -like 1, associated with underlying cancer)

Question 7

Lupus nephritis

Answer 7

Negative PLA2R

Question 8

Focal segmental glomerulosclerosis mesangial collapse and sclerosis

Answer 8

Primary
Secondary

Question 9

Preeclampsia
Placenta released excessive protein

Answer 9

Soluble fms-like tyrosine kinase stimulates Soluble vascular endothelial growth factor and placental growth factor