Metabolism Flashcards
Olezarsen
Reduces hepatic synthesis of apolipoprotein C-III thereby decreasing triglycerides
Fatty liver is now called
metabolic-associated fatty liver,
Insulin resistance causes:
- Fatty acid storage in hepatocytes
- De novo synthesis of fatty acids
- Lipolysis is inhibited
- adiponectin is inhibited (antilipogenesis)
- Increase systemic inflammation and oxidative stress
Adipose tissue releases inflammatory markers
- Tumor necrosis factor alpha
- iL-1
- iL-6
- CRP
Inflammatory cytokines induce
- Fibrinogen
- Factor VIII
- plasminogen activator inhibitor-1
Oxidative stress induces
Platelet aggregation
Nomenclatura for fatty liver 2023
meta- bolic dysfunction-associated steatotic liver disease’ (MASLD)
MASH (metabolic dysfunction-associated steatohepatitis.
Tirzepatide (reduces MASH, fibrosis)
Agonistglucose dependent insulinotrope polypeptide and glucagon like peptide-1receptor agonist.(7/25/24 vol. 391 #4 p299
MASH NEJM 7/25/24 Vol391#4 p311-319
Survodutide
Dual agonism GLP1
MASH NEJM 2024 ;390: 497-509
Resmetirom
Evolucamab
Anti lipid
Labs to determine type 1 or type 2 DM
Type 1 or type 2
GAD 65
IA2
ICA
ZINC TRANSPORTER
Intestinal congestion
Gut bacterial translocation in intestinal congestion
Intestinal congestion
Gut bacterial translocation in intestinal congestion