Metabolism Flashcards

1
Q

Olezarsen

A

Reduces hepatic synthesis of apolipoprotein C-III thereby decreasing triglycerides

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2
Q

Fatty liver is now called

A

metabolic-associated fatty liver,

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3
Q

Insulin resistance causes:

A
  1. Fatty acid storage in hepatocytes
  2. De novo synthesis of fatty acids
  3. Lipolysis is inhibited
  4. adiponectin is inhibited (antilipogenesis)
  5. Increase systemic inflammation and oxidative stress
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4
Q

Adipose tissue releases inflammatory markers

A
  1. Tumor necrosis factor alpha
  2. iL-1
  3. iL-6
  4. CRP
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5
Q

Inflammatory cytokines induce

A
  1. Fibrinogen
  2. Factor VIII
  3. plasminogen activator inhibitor-1
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6
Q

Oxidative stress induces

A

Platelet aggregation

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7
Q

Nomenclatura for fatty liver 2023

A

meta- bolic dysfunction-associated steatotic liver disease’ (MASLD)

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8
Q

MASH (metabolic dysfunction-associated steatohepatitis.

A

Tirzepatide (reduces MASH, fibrosis)
Agonistglucose dependent insulinotrope polypeptide and glucagon like peptide-1receptor agonist.(7/25/24 vol. 391 #4 p299

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9
Q

MASH NEJM 7/25/24 Vol391#4 p311-319

A

Survodutide
Dual agonism GLP1

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10
Q

MASH NEJM 2024 ;390: 497-509

A

Resmetirom

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11
Q

Evolucamab

A

Anti lipid

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12
Q

Labs to determine type 1 or type 2 DM

A

Type 1 or type 2
GAD 65
IA2
ICA
ZINC TRANSPORTER

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13
Q

Intestinal congestion

A

Gut bacterial translocation in intestinal congestion

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14
Q

Intestinal congestion

A

Gut bacterial translocation in intestinal congestion

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