Metabolism

Question 1

Olezarsen

Answer 1

Reduces hepatic synthesis of apolipoprotein C-III thereby decreasing triglycerides

Question 2

Fatty liver is now called

Answer 2

metabolic-associated fatty liver,

Question 3

Insulin resistance causes:

Answer 3

1. Fatty acid storage in hepatocytes
2. De novo synthesis of fatty acids
3. Lipolysis is inhibited
4. adiponectin is inhibited (antilipogenesis)
5. Increase systemic inflammation and oxidative stress

Question 4

Adipose tissue releases inflammatory markers

Answer 4

1. Tumor necrosis factor alpha
2. iL-1
3. iL-6
4. CRP

Question 5

Inflammatory cytokines induce

Answer 5

1. Fibrinogen
2. Factor VIII
3. plasminogen activator inhibitor-1

Question 6

Oxidative stress induces

Answer 6

Platelet aggregation

Question 7

Nomenclatura for fatty liver 2023

Answer 7

meta- bolic dysfunction-associated steatotic liver disease’ (MASLD)

Question 8

MASH (metabolic dysfunction-associated steatohepatitis.

Answer 8

Tirzepatide (reduces MASH, fibrosis)
Agonistglucose dependent insulinotrope polypeptide and glucagon like peptide-1receptor agonist.(7/25/24 vol. 391 #4 p299

Question 9

MASH NEJM 7/25/24 Vol391#4 p311-319

Answer 9

Survodutide
Dual agonism GLP1

Question 10

MASH NEJM 2024 ;390: 497-509

Answer 10

Resmetirom

Question 11

Evolucamab

Answer 11

Anti lipid