Neurology Flashcards
Cortical spreading depression
Assoc: trauma, migraines, hemorrhage (Rx magnesium, topiramate)
Sotagliflozin (sglt1 and SGLT2 inhibitor)
May reduce stroke risk
Cognitive motor dissociation
Functional MRI
EEG
Albuminocytologic dissociation
Guillain-Barre
Elevated CSF protein
Normal white blood cell count
New stroke and New afib
- Minor to moderate-after 48 hrs DOAC
- Major stroke 6-7 days start DOAC Fischer U et al NEJM 2023
NIHSS <3, stroke OR
ABCD2 of 4 or more, 21 days of dual antiplatelet
Ticagrelor (if plavix unresponsive) and aspirin
Carotid stenosis 70-99% , fix it.
Intracranial stenosis 90 days dual antiplatelet treatment
Guillén Barre
Paresthesias and weakness
FVC/MIF (MIF negative value) NORMAL >20cc/kg
EMG/NCS
Upper motor exam
- Pronator drift
- Fine finger movements (toe tap
- Finger extensors, big toe extensors
Falls in elderly
- Parkinson
- Neuropathy
- Cervical myelopathy (Lhermitte sign
Afib burden
G
G
High ICP TREATMENT
Goal is to get blood out of brain
Head of bed > 30 degrees
Mannitol reduce
Cerebral perfusion pressure = MAP-ICP
Meningitis
- Vancomycin q6 hrs
- CTX 2g q12
- Amp 2g q4 (bactrim)
- DEXA 10 q 6 hrs
Aphasia testing
- Fluency naming , conversation
- Comprehension: follows difficult tasks
- Repetition: today is a sunny day
Attention span:
Five digits
24637
New brain mass
Tumefactive multiple sclerosis
Attention span
Digits forward 5724631
Aphasia testing
Fluency
Comprehension (follows difficult commands)
Repetition “today is a sunny day)
Aphasia: repetition, fluency, comprehension
Broca lesion: fluency bad, repetition bad
Wernicke: repetition bad, comprehension bad
Conduction, repetition bad (fluency and comprehension good)
Speech
Fluency: naming, conversation
Comprehension: complex commands
Repetition “today is a sunny day
Aphasia
Broca= poor fluency
Conduction = poor repetition
Wernicke = poor comprehension
Cranial nerves
II pupils, acuity, visual fields
3,4,6 extra ocular movements
5 sensation
7 facial strength
8 hearing
9, 20 palatal elevation
XI SCM, trapezius
XII TONGUE
Do not add aspirin to pts on AC and stroke
European stroke journal 2023 Volume 8(3)722-730
Headache
Vascular, infection, inflammation, neoplastic,
Levels of consciousness
Alert, lethargy, obtunded, stupor, coma
Light headed
Decrease perfusion to CNS
Increased vagal tone
VTE
Dysrhythmia
Blood loss
Vertigo, disequilibrium
Disorders affecting the posterior circulation (TIA, ischemic, hemorrhagic,
Cerebral venous sinus thrombosis
Space occupying lesion
Infection
Inflammation
Posterior reversible encephalopathy syndrome
Reversible cerebral vasoconstriction
MRI
Diffusion weighted images- look for restricted diffusion: thrombosis
Susceptibility weighted images look for microhemorrhage associated with fat embolism
PRES POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME
Vision changes, nausea, vomiting, headache, seizure