Hematology Flashcards
Metalloprotease ADAMSTS13
Cleaves Willebrand factor
PLASMIC SCORE
Scoring system that aids in diagnosing iTTP
Thrombotic anti phospholipid syndrome
Eculizumab and ravulizumab
Antiphospholipid
Lupus anticoagulant, anticardiolipin, anti-beta-2-glycoprotein antibodies
Complement activation
- Classical (Aby-atgn complex)
2.Lectin pathway activ. Mannose binding lectin - Alternative pathway
Main players of complement
C3, C5a (potent pro inflammatory),C5b-9 ( membrane attack complex)
Complement mediated disorders
Paroxysmal nocturnal hemoglobinuria, cold agglutinin, aHUS,
Anaphylatoxins C3a, C5a, C5b-9
C3a, C5a, C5b-9
C3a and C5a release
Pro inflammatory & procoagulant cytokines such: tumor necrosis factor,
Interleukin-6 from monocytes & endothelial cells
Monocytes & endothelial cells induce
TNF & interleukin -6 which induce tissue factor
C5a recruits
Neutrophils which induces neutrophil tissue factor dependent procoagulant.
C5a-9 induces secretion via endothelial and platelets
VWF, p selectin, pro- inflammatory cytokines, procoagulant extracellular vesicles
Monocytes release
TNF & Interleukin 6
Neutrophil release
Tissue factor dependent procoagulant activity
Neutrophils, monocytes, platelets
Hypercoagulable