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MedicalCNS > Hematology > Flashcards

Hematology Flashcards

1
Q

Metalloprotease ADAMSTS13

A

Cleaves Willebrand factor

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2
Q

PLASMIC SCORE

A

Scoring system that aids in diagnosing iTTP

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3
Q

Thrombotic anti phospholipid syndrome

A

Eculizumab and ravulizumab

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4
Q

Antiphospholipid

A

Lupus anticoagulant, anticardiolipin, anti-beta-2-glycoprotein antibodies

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5
Q

Complement activation

A
  1. Classical (Aby-atgn complex)
    2.Lectin pathway activ. Mannose binding lectin
  2. Alternative pathway
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6
Q

Main players of complement

A

C3, C5a (potent pro inflammatory),C5b-9 ( membrane attack complex)

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7
Q

Complement mediated disorders

A

Paroxysmal nocturnal hemoglobinuria, cold agglutinin, aHUS,

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8
Q

Anaphylatoxins C3a, C5a, C5b-9

A

C3a, C5a, C5b-9

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9
Q

C3a and C5a release

A

Pro inflammatory & procoagulant cytokines such: tumor necrosis factor,
Interleukin-6 from monocytes & endothelial cells

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10
Q

Monocytes & endothelial cells induce

A

TNF & interleukin -6 which induce tissue factor

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11
Q

C5a recruits

A

Neutrophils which induces neutrophil tissue factor dependent procoagulant.

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12
Q

C5a-9 induces secretion via endothelial and platelets

A

VWF, p selectin, pro- inflammatory cytokines, procoagulant extracellular vesicles

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13
Q

Monocytes release

A

TNF & Interleukin 6

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14
Q

Neutrophil release

A

Tissue factor dependent procoagulant activity

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15
Q

Neutrophils, monocytes, platelets

A

Hypercoagulable

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16
Q

C3 activates platelets and fibrin formation

A
17
Q

Complementopathies cause thrombosis often refractory to anticoagulation and seen triggered in:

A

Pregnancy, inflammation, cancer, PNH, cold agglitinin, aHUS, transplant microangiopathy, HELLP, APS, CAPS

18
Q

Complement inhibitors

A

Eculizumab, ravlizumab

19
Q

Complement inhibition

A

CAPS, HELLP

20
Q

Waldenström macroglobulinemia

A
  1. Indolent B cell lymphoma
  2. Hepatosplenomegaly
  3. Lymphadenopathy
  4. Circulating IgM
21
Q

ITP

A

Anti-CD 38 monoclonal antibody
CM313

22
Q

Iron deficiency (hepcidin controls release of iron)

A
  1. Ferritin <100
    OR
  2. Ferritin 100-300 and total iron saturation <20%
23
Q

HELLP syndrome

A

Hemolysis
Elevated LFT
LOW PLATELETS

24
Q

Autoimmune cytopenia

A
25
Q

Cryoglobulinemia

A

Diagnostic testing; cbc with diff, SPEP, serum protein immunofixation,CT scan (thoracic, abdomen), PET scan, bone marrow biopsy.
Type II,III VIRAL PANEL B,C
ANA, anti double dna, salivary gland biopsy

26
Q

Flow cytometry

A

Helps distinguish malignancy

MedicalCNS (38 decks)

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