GI

Question 1

Hepatomegaly

Answer 1

AL Amyloidosis

Question 2

Functional hypospenim

Answer 2

AL amyloidosis

Question 3

Liver abscess testing

Answer 3

1. 1,3-B-D-glucan
   2.MTB, HIV, Epstein Barr, CMV, hepB,C
2. Chlamydia psittaci,coxiella burnetti
3. Brucellosis, bartonellosis, malaria listeriosis, histoplasmosis, babesiosis,cocci,crypto, blastomycosis, malaria, toxo, rpr, ehrlichosis, lyme, anaplasmosis

Question 4

Non cirrhotic portal hypertension in adults

Answer 4

Nodular regenerative hyperplasia

Question 5

Nodular regenerative hyperplasia

Answer 5

Causes hypersplenism , splenic sequestration related cytopenias, infections, pulmonary arterial hypertension, hepatopulmonary syndrome

Question 6

Nodular regenerative hyperplasia,

Answer 6

Arises from:
1. Common variable immunodeficiency
2. Combined immunodeficiency’s
3. Phagocytes defect
4, chronic granulomatous disease

Question 7

Nodular regenerative hyperplasia in immunodeficiency

Answer 7

Occurs with inflammatory complications:
1. High levels of bacterial DNA
2. Soluble CD14
3. Interferon -y activity (higher is worse)

Question 8

Cirrhosis (thrombocytopenia is not a predictor of procedural bleeding)
JTH 2024;22 2653-2669

Answer 8

1. Increased levels of willebrand factor
2. Decreased ADAMTS-13
3. Decreased production protein S,C, antithrombin
4. Hypofibrinogemia