Redox Folding Flashcards
1
Q
what is OxyR?
A
transcriptional activator whose activity can be upregulated (at 3 levels) by 3 types of oxidation
2
Q
what is classic redox regulation?
A
S-thiolation or dethiol. –> two S’s are oxidized and form a disulfide bond
3
Q
what is advanced redox regulation?
A
S-nitrosylation (S-NO), s-glutathionylation (S-SG), S-hydroxylation (S-OH) which are reversible–> regulation; irreversible oxidations often lead to disease