Redox Folding Flashcards

1
Q

what is OxyR?

A

transcriptional activator whose activity can be upregulated (at 3 levels) by 3 types of oxidation

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2
Q

what is classic redox regulation?

A

S-thiolation or dethiol. –> two S’s are oxidized and form a disulfide bond

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3
Q

what is advanced redox regulation?

A

S-nitrosylation (S-NO), s-glutathionylation (S-SG), S-hydroxylation (S-OH) which are reversible–> regulation; irreversible oxidations often lead to disease

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