Amino Acids Flashcards
1
Q
what are the modes of enzymatic modification of aa’s?
A
acetylation, phosphorylation, ubiquitylation, methylation
2
Q
how does acetylation and deacetylation occur?
A
through the use of A-CoA and HAT for acetylation, and H2O and HDAC for deac.
3
Q
how does phos and dephos occur?
A
protein kinases use ATP to phos, pohsohatase uses water to dephos
4
Q
how does methylation and demeth. occur?
A
methyltransferase uses SAM (to SAH) to methylate; amine oxidase demethylase uses O2 to demeth producing h2o2 or an aldehyde
5
Q
how does ubiquitylation/deubiq occur?
A
ubiquitin + ATP through ubiq. ligase (E3);; deubiquilatying isopeptidease with use of water deubiqs
