Antibody structure

Question 1

Where do b cells mature in birds?

Answer 1

Bursa of fabricius

Question 2

what are the complementary systems of the immune response?

Answer 2

humoral (fluid) and cellular

Question 3

two regions of the Ab–> Fab and Fc

Answer 3

ya

Question 4

variable and constant region of L chain coded on different amino acids

Answer 4

ya

Question 5

only about 10 different types of constant regions

Answer 5

ya

Question 6

linear vs conformational determinant

Answer 6

linear–>sequential aa’s, Ab ca still bind when Ag is denatured
conf–> determinant only present when Ag in native conf

Question 7

flexibility of the hinge and VC JUNCTIONS allows for Ab to bend to better bind the epitopes

Answer 7

ya

Question 8

due to flexibility (at the hinge and VC junctions)–> abs can bind in different confs= dimer, trimer, tetramer

Answer 8

ya

Question 9

Fc binds to receptor on macrophage–> macrophage invaginates and engulfs Ab and Ag–>lysosome degraded the Ag

Answer 9

ya

Question 10

immunoglobulins are Abs

Answer 10

ya

Question 11

what is the immunoglobulin fold?

Answer 11

VC domains form two beta sheets–>linked by disulfide bridge–>form cylinder (beta sandwich)–>beta-sandwich formed by Igs is known as the immunoglobulin fold

Question 12

what are the hypervariable loops known as in Igs?

Answer 12

CDRs–>complementarity determining region