Red Blood Cell

Question 1

Diameter of a red blood cell

Answer 1

7-10microns

Question 2

The red blood cell has nucleus

Answer 2

False

The red blood cell has no nucleus and no organelle

Question 3

What area in the spleen does the red blood cells pass through

Answer 3

The red pulp of the spleen

Question 4

Characteristics of the membrane of RBC

Answer 4

Highly elastic
Semi permeable lipid bilayer

Question 5

RBC are what in shape

Answer 5

Biconcave in shape( round cell with an area of central pallour when in a peripheral view)

Question 6

The proteins that extends from the outer side of the RBC to the cytoplasmic side is

Answer 6

Integral membrane proteins

Question 7

Membrane proteins limited to the cytoplasmic side are the

Answer 7

Peripheral MP and the help to produce cytoskeleton

Question 8

Integral membrane protein of red blood cell are

Answer 8

GLYCOPHORIN A B C D
PROTEIN Band 3

Question 9

Peripheral membrane protein are

Answer 9

Spectrin
Actin (band 3)
Ankyrin(band 2.1)
Band 4.1 and 4.2
Adducin
P55

Question 10

2 types of arrangement of proteins

Answer 10

Vertical and horizontal

Question 11

Vertical membrane protein in rbc include

Answer 11

Ankyrin
Band 3
Protein 2.1
Glycophorin c

Question 12

Horizontal membrane proteins include

Answer 12

Alpha and beta spectrum
Protein 4.1
Actin

Question 13

Hereditary spherocytosis is due to

Answer 13

A defect in the gene of the vertical protein ankyrin which ties the bilipid layer

Question 14

Hereditary spherocytosis can be present at what age

Answer 14

Any age

Question 15

A characteristic feature of hereditary spherocytosis 1

Answer 15

Haemolytic anaemia and spherical erythrocyte

It is a heterogeneous alteration in a gene ( Ankyrin)

Question 16

Hereditary spherocytosis 2 present with a characteristic feature of

Answer 16

Jaundice and hyper bilirubinemia on new born babies( neonates)

Question 17

Hereditary elliptocytosis is also called

Answer 17

Hereditary ovallocytosis

Question 18

Characteristic feature of hereditary elliptocytosis is

Answer 18

No hemolysis and no anemia Hereditary by autosomal dominant
Oval enlongated rbc

Question 19

Most common defect of rbc is

Answer 19

Hereditary spherocytosis

Question 20

The most severe form of hereditary elliptocytosis defect of rbc is

Answer 20

Hereditary pyropoikilocytosis

Question 21

Hereditary elliptocytosis affect what protein

Answer 21

Horizontal protein , alpha and beta spectrin and protein 4.1

Question 22

Southeast Asian ovalocytosis (SAO) affect what protein

Answer 22

Band 3 deletion

Question 23

Hereditary pyropoikilocytosis affects what protein

Answer 23

Spectrin

Question 24

What test is used in hereditary spherocytosis

Answer 24

Coombs test

Question 25

Coombs test in HS IS

Answer 25

Negative

Question 26

Management of HS

Answer 26

Folic acid supplements Transfusions Erythropoeitin Splenectomy

Question 27

Hereditary spherocytosis on adult and older children presents with

Answer 27

Haemolytic anaemia Splenomegaly Gall stones

Question 28

Patients with severe hereditary spherocytosis may undergo

Answer 28

Splenectomy

Question 29

What protein is commonly affected in hereditary elliptocytosis

Answer 29

Spectrin ( alpha 65%and beta30%)

Question 30

Hereditary spherocytosis majorly affects the membrane by

Answer 30

Affecting the vertical protein that tie the skeleton to the lipid bilayer

Question 31

HS is suspected in an individual in what test

Answer 31

When Coombs test is negative( so they are not immune to HS)

Question 32

The most abundant peripheral protein in the rbc is

Answer 32

Spectrin

Question 33

What peripheral protein anchors the lipid bilayer of rbc to the membrane Skelton

Answer 33

Ankyrin

Question 34

May link the cytoskeleton to the membrane by its association to glycophorin is the function of

Answer 34

Protein 4.1

Question 35

RBC glycoprotein is usually

Answer 35

Glycophorin

Question 36

Elliptocytosis defect in rbc are more permeable to what ion

Answer 36

Sodium NA 2+

Question 37

A defect in only alpha Spectrin in rbc

Answer 37

Hereditary Pyropoikilocytosis