Red Blood Cell Flashcards
Diameter of a red blood cell
7-10microns
The red blood cell has nucleus
False
The red blood cell has no nucleus and no organelle
What area in the spleen does the red blood cells pass through
The red pulp of the spleen
Characteristics of the membrane of RBC
Highly elastic
Semi permeable lipid bilayer
RBC are what in shape
Biconcave in shape( round cell with an area of central pallour when in a peripheral view)
The proteins that extends from the outer side of the RBC to the cytoplasmic side is
Integral membrane proteins
Membrane proteins limited to the cytoplasmic side are the
Peripheral MP and the help to produce cytoskeleton
Integral membrane protein of red blood cell are
GLYCOPHORIN A B C D
PROTEIN Band 3
Peripheral membrane protein are
Spectrin
Actin (band 3)
Ankyrin(band 2.1)
Band 4.1 and 4.2
Adducin
P55
2 types of arrangement of proteins
Vertical and horizontal
Vertical membrane protein in rbc include
Ankyrin
Band 3
Protein 2.1
Glycophorin c
Horizontal membrane proteins include
Alpha and beta spectrum
Protein 4.1
Actin
Hereditary spherocytosis is due to
A defect in the gene of the vertical protein ankyrin which ties the bilipid layer
Hereditary spherocytosis can be present at what age
Any age
A characteristic feature of hereditary spherocytosis 1
Haemolytic anaemia and spherical erythrocyte
It is a heterogeneous alteration in a gene ( Ankyrin)
Hereditary spherocytosis 2 present with a characteristic feature of
Jaundice and hyper bilirubinemia on new born babies( neonates)
Hereditary elliptocytosis is also called
Hereditary ovallocytosis
Characteristic feature of hereditary elliptocytosis is
No hemolysis and no anemia Hereditary by autosomal dominant
Oval enlongated rbc
Most common defect of rbc is
Hereditary spherocytosis
The most severe form of hereditary elliptocytosis defect of rbc is
Hereditary pyropoikilocytosis
Hereditary elliptocytosis affect what protein
Horizontal protein , alpha and beta spectrin and protein 4.1
Southeast Asian ovalocytosis (SAO) affect what protein
Band 3 deletion
Hereditary pyropoikilocytosis affects what protein
Spectrin
What test is used in hereditary spherocytosis
Coombs test
Coombs test in HS IS
Negative
Management of HS
Folic acid supplements
Transfusions
Erythropoeitin
Splenectomy
Hereditary spherocytosis on adult and older children presents with
Haemolytic anaemia
Splenomegaly
Gall stones
Patients with severe hereditary spherocytosis may undergo
Splenectomy
What protein is commonly affected in hereditary elliptocytosis
Spectrin ( alpha 65%and beta30%)
Hereditary spherocytosis majorly affects the membrane by
Affecting the vertical protein that tie the skeleton to the lipid bilayer
HS is suspected in an individual in what test
When Coombs test is negative( so they are not immune to HS)
The most abundant peripheral protein in the rbc is
Spectrin
What peripheral protein anchors the lipid bilayer of rbc to the membrane Skelton
Ankyrin
May link the cytoskeleton to the membrane by its association to glycophorin is the function of
Protein 4.1
RBC glycoprotein is usually
Glycophorin
Elliptocytosis defect in rbc are more permeable to what ion
Sodium NA 2+
A defect in only alpha Spectrin in rbc
Hereditary Pyropoikilocytosis
