Myleopoeisis And Beningn Leucokcyte Disorder

Question 1

What is myleopoeisis

Answer 1

The formation of CFU-GM monocytes, neutrophils, basophils and eosinophils

Question 2

The main cytokines involved in neutrophils differentiation is

Answer 2

G-CSF AND GM-CSF

Question 3

In myeleopoesis, IL-3 and GM-CSF play a role in

Answer 3

Eosinophils and basophils differentiation and maturation

Question 4

The cytokine that plays a role in the terminal differentiation of eosinophils is

Answer 4

IL-5

Question 5

The earliest granulocyte precursor recognized my the microscope is

Answer 5

The Myeoblast

Question 6

Properties of the myeoblast

Answer 6

Large cell
High nucleus to cytoplasm
Scanty cytoplasm
Prominent nucleoli. And
Minimal to no granules

Question 7

Myloblast differentiate into

Answer 7

Promylocyte

Question 8

Myeloblast to promyelocyte is due to

Answer 8

Acquisition of huge quantities of primary granules

Question 9

Promyelocyte to myelocyte is due to

Answer 9

Acquisition of secondary granules

Question 10

It takes _____cell division from myeloblast to myelocyte

Answer 10

4-5days

Question 11

Myelocyte to blood transit times takes

Answer 11

5-7days …. But 48hrs in infective stage

Question 12

Neutrophils spend how much time in peripheral blood

Answer 12

10hrs

Question 13

Cells Percentages in bone marrow

Myeloblast
Promyelocyte
Myelocyte.
Meta myelocyte
Band form
Polymophonuclear

Answer 13

0.2%-1.5%
2-4%
8-16%
9-25%
9-15%
6-12%

Question 14

Stem cell characteristics

Answer 14

Small population
CD4. CD8- markers
Population maintained through self renewal
Not morphologicaly recognizable

Question 15

Myelopoeisis is the formation of

Answer 15

Granulocyte and monocyte

Question 16

Interleukin 3 does what to stem cell

Answer 16

Stimulates the differentiation of stem cells to myeloid and lymphoid

Question 17

Interleukin 5

Answer 17

The cytokine that cause the terminal differentiation of eosinophils

It is a powerful chemoattractant to eosinophils

Question 18

M-CSF

Answer 18

Is a monocyte stimulating factor

Question 19

It takes ______ cell division from promyleoblast to myelocyte

Answer 19

4-5

Question 20

The transit time of myelocyte to blood is

Answer 20

5-7 days

Question 21

Blood neutrophil pool include

Answer 21

Marginated and circulating pool

Question 22

Marginated pool of neutrophils are mainly found in

Answer 22

The lungs

Question 23

What is myelopoeisis

Answer 23

Formation of granulocyte

Question 24

All Haematopoeisis as well as myelopoeisis begins with

Answer 24

Pluripotent HSC

Question 25

Stachostic model believes that myelopoeisis begins from

Answer 25

Intrinsic factor on a random basis

Question 26

What model in myelopoeisis lineage formation believes in extrinsic factor

Answer 26

Inductive model

Question 27

Regulator for neutrophils is

Answer 27

G-CSF AND GM-CSF

Question 28

Regulator for stem cells is

Answer 28

IL 3

Question 29

IL5 is the regulator for

Answer 29

Eosinophils

Question 30

Regulator for IL3 and GM CSF is

Answer 30

Basophil and eosinophils

Question 31

IL 6 regulates

Answer 31

Megakaryopoeisis

Question 32

Myeloblast to myelocyte takes

Answer 32

4- 5 days transition

Question 33

Neutrophils spends how many hrs in the blood

Answer 33

6-10hrs

Question 34

What is the first line of defense
ASpa what cell

Answer 34

Neutrophils

Question 35

They take care of parasitic worm infection

Answer 35

Eosinophils