Myleopoeisis And Beningn Leucokcyte Disorder Flashcards
What is myleopoeisis
The formation of CFU-GM monocytes, neutrophils, basophils and eosinophils
The main cytokines involved in neutrophils differentiation is
G-CSF AND GM-CSF
In myeleopoesis, IL-3 and GM-CSF play a role in
Eosinophils and basophils differentiation and maturation
The cytokine that plays a role in the terminal differentiation of eosinophils is
IL-5
The earliest granulocyte precursor recognized my the microscope is
The Myeoblast
Properties of the myeoblast
Large cell
High nucleus to cytoplasm
Scanty cytoplasm
Prominent nucleoli. And
Minimal to no granules
Myloblast differentiate into
Promylocyte
Myeloblast to promyelocyte is due to
Acquisition of huge quantities of primary granules
Promyelocyte to myelocyte is due to
Acquisition of secondary granules
It takes _____cell division from myeloblast to myelocyte
4-5days
Myelocyte to blood transit times takes
5-7days …. But 48hrs in infective stage
Neutrophils spend how much time in peripheral blood
10hrs
Cells Percentages in bone marrow
Myeloblast
Promyelocyte
Myelocyte.
Meta myelocyte
Band form
Polymophonuclear
0.2%-1.5%
2-4%
8-16%
9-25%
9-15%
6-12%
Stem cell characteristics
Small population
CD4. CD8- markers
Population maintained through self renewal
Not morphologicaly recognizable
Myelopoeisis is the formation of
Granulocyte and monocyte
Interleukin 3 does what to stem cell
Stimulates the differentiation of stem cells to myeloid and lymphoid
Interleukin 5
The cytokine that cause the terminal differentiation of eosinophils
It is a powerful chemoattractant to eosinophils
M-CSF
Is a monocyte stimulating factor
It takes ______ cell division from promyleoblast to myelocyte
4-5
The transit time of myelocyte to blood is
5-7 days
Blood neutrophil pool include
Marginated and circulating pool
Marginated pool of neutrophils are mainly found in
The lungs
What is myelopoeisis
Formation of granulocyte
All Haematopoeisis as well as myelopoeisis begins with
Pluripotent HSC
Stachostic model believes that myelopoeisis begins from
Intrinsic factor on a random basis
What model in myelopoeisis lineage formation believes in extrinsic factor
Inductive model
Regulator for neutrophils is
G-CSF AND GM-CSF
Regulator for stem cells is
IL 3
IL5 is the regulator for
Eosinophils
Regulator for IL3 and GM CSF is
Basophil and eosinophils
IL 6 regulates
Megakaryopoeisis
Myeloblast to myelocyte takes
4- 5 days transition
Neutrophils spends how many hrs in the blood
6-10hrs
What is the first line of defense
ASpa what cell
Neutrophils
They take care of parasitic worm infection
Eosinophils
