Erythropoeisis

Question 1

How many days did it take the colony forming unit erythroid (CFU-E) to become erythroblast

Answer 1

It takes 7 days under the stimulation of erythropoietin

Question 2

How many days does it take Reticulocyte to become matured

Answer 2

1 to 2 days to become an erythrocyte

Question 3

Life span of red blood cells

Answer 3

100-120days

Question 4

Erythroid progenitor cell occupies about how much among the bone marrow cells

Answer 4

1/3rd about 33%

Question 5

Stem cells found in bone marrows are

Answer 5

Uncommitted pluripotent haematopoetic stem cells

Question 6

Growth factor that stimulates uncommitted PHSC in the bone marrow is

Answer 6

FLT Ligand

Question 7

Erythropoeisis occurs where

Answer 7

Majorly in the bone marrow then travels to the peripheral blood vessel

Question 8

Steps in forming a matured erythrocyte

Answer 8

PROERYTHROBLAST
|
BASOPHILLIC ERYTHROBLAST
|
POLYCHROMATOPHILLIC ERYTHROBLAST
|
ORTHOCHROMATIC ERTHROBLAST
|
RETICULOCYTE
|
MATURED ERYTHROCYTE

Question 9

Explain the stages of red blood cell formation

Answer 9

1)Proerythroblast: the nucleus is very large, cytoplasm is basophillic and no formation of haemoglobin

2) BASOPHILLIC erythroblast: the nucleus has reduced, no presence of haemoglobin

3) Polychromophillic erythroblast: haemoglobin appears which stain acidic and cytoplasm stain BASOPHILLIC

4)Orthochromatic erythroblast: nucleus disappears, haemoglobin increase well making the cytoplasm acidophillic

5) RETICULOCYTE

After 1 to 2 days MATURED ERYTHROCYTE

Question 10

Stimulating factors of Erythropoeisis

Answer 10

Hypoxia and Erythropoeitin

Question 11

What are the maturing factor of red blood cells

Answer 11

Vitamin B12 and folic acid for the maturation of the dna in RBC

Question 12

Function of vitamin b12 in Erythropoeisis and it’s deficiency

Answer 12

Vitamin b12 is used in the production of dna in RBC

it’s deficiency leads to pernicious anaemia or megaloblastic anaemia

Question 13

Vitamin b12 is gotten majorly through
And what aids it’s digestion

Answer 13

Diet
And intrinsic factor of castle

Question 14

Factors needed to produce haemoglobin

Answer 14

1) Iron and copper ( for heme synthesis)

2)Vitamin C ( iron absorption)

3)amino acid ( Globin synthesis)

Question 15

The transcription factor for erythroid division and growth is

Answer 15

GATA-1 with its cofactor FOG -1

Question 16

GATA 1 does what

Answer 16

It binds the dna of red blood cells to other protein to cause the division of immature rbc to special

Question 17

Thallesmia

Answer 17

A condition where there is an abnormal reduction of haemoglobin in the blood

Question 18

Sickle cell is

Answer 18

An abnormal production of Globin in the blood I.e the haemoglobin count is normal but the quality is not normal

Question 19

What is erythropoietin

Answer 19

A hormone secreted by the kidney and liver
A circulating glycoprotein

Question 20

Erythropoietin acts on

Answer 20

Colony formation unit-erythroid

Their receptors appear little on BFU-E

Question 21

Condition that stimulate Erythropoeisis

Answer 21

High altitude
Cardiac failure
Lung problem
Anaemia
Poor blood flow

Question 22

Erythropoeitin prevent apoptosis of rbc

TRUE/FALSE

Answer 22

True

Question 23

Intrinsic factor of castle is gotten from

Answer 23

Gastric juice in our stomach

Question 24

Deficiency of iron leads to

Answer 24

Microcytic anaemia or hypochromic anaemia

Used in the production of haemoglobin

Question 25

The receptor for iron intake in Erythropoeisis is

Answer 25

CD71( transferrin receptor)

Question 26

Erythropoeisis takes a maximum of

Answer 26

14 days in vitro

Question 27

Formation of pro erythroblast to reticulocyte takes

Answer 27

7 days