Haemoglobin Flashcards
The main function of red blood cell
To carry oxygen to tissues and take co2 from tissues to lungs
What enables the exchange of gases Between RBC and tissue
Haemoglobin
Haemoglobin is made up of
Protein - Globin ( alpha and beta Globin)
Non protein part- heme
Heme is made up of
Iron and porphyrin
The iron in the gene must remain in the _ to do what
Ferrous state FE2+ so as to carry oxygen
Hemoglobin with oxygen is called - and why
Oxyhemoglobin
Heme is produced where
Mitochondrion
Note: matured RBC has no organelle but Immatured RBC HAS before it becomes Remenat called reticulocyte
Hemeoglobin has how many iron
4 iron used to carry the oxygen
Norman heamoglobin consist of how many polypeptide chain which are
2 alpha and 2 beta chain with its own heme group
A coenzyme in the synthesis of heme is
Pyridoxial phosphate B6
Heme is gotten from
Succinyl coa and glycine
What enzyme is responsible for heme synthesis
ALA synthase
Methaemoglobinaemia is
Is a disorder that affects iron in hemoglobin that causes the iron to be in a ferric state rather than a ferrous state
Types of haemoglobin
Hb A found in adult with 95% A2 and B2
Hb f and Hb A2 found in fetus with gamma and delta Globin
Globin synthesis begins at
3rd week of gestation
Globin synthesis takes place in
Poly ribosomes
Globin in the fetus is
Gower1, Portland and gower 2
Pophyrin is a
Tetrapyrolle structure
When haemoglobin is oxygenated, what molecule is pushed out
2,3diphsophoglycerate or 2,3bisphosphoglycerate
What are signs medically
What the doctor sees
What are symptoms medically
What the patient feels
Ph of blood is
7.4
Hematocrit
Is the volume of red blood cell in blood expressed in percentage
Normal hematocrit value is
45%
Plasma forms about _______ percent of blood volume
55%
At what stage does fetal haemoglobin becomes adult heamoglobin
3-6month after birth
When we inhale fumes from car engines ( carbon monoxide)
Why do we choke up
Haemoglobin has more likeness ( like 100 times) for carbon monoxide than oxygen
Carboxy haemoglobin
Heamoglobin with carbon monoxide
Haemoglobin is formed at what stage of Erythropoeisis
Polychromaphillic stagev
Haemoglobin with carbon dioxide is called
Carbon mono haemoglobin
Rate limiting enzyme in heme synthesis
ALA synthase
Aminolevulennic synthase
The coenzyme for heme synthesis is
Pyridoxial phosphate vitamin B6
Globin synthesis is hemoglobin takes place in
Polyribosome
