Haemoglobin

Question 1

The main function of red blood cell

Answer 1

To carry oxygen to tissues and take co2 from tissues to lungs

Question 2

What enables the exchange of gases Between RBC and tissue

Answer 2

Haemoglobin

Question 3

Haemoglobin is made up of

Answer 3

Protein - Globin ( alpha and beta Globin)

Non protein part- heme

Question 4

Heme is made up of

Answer 4

Iron and porphyrin

Question 5

The iron in the gene must remain in the _ to do what

Answer 5

Ferrous state FE2+ so as to carry oxygen

Question 6

Hemoglobin with oxygen is called - and why

Answer 6

Oxyhemoglobin

Question 7

Heme is produced where

Answer 7

Mitochondrion

Note: matured RBC has no organelle but Immatured RBC HAS before it becomes Remenat called reticulocyte

Question 8

Hemeoglobin has how many iron

Answer 8

4 iron used to carry the oxygen

Question 9

Norman heamoglobin consist of how many polypeptide chain which are

Answer 9

2 alpha and 2 beta chain with its own heme group

Question 10

A coenzyme in the synthesis of heme is

Answer 10

Pyridoxial phosphate B6

Question 11

Heme is gotten from

Answer 11

Succinyl coa and glycine

Question 12

What enzyme is responsible for heme synthesis

Answer 12

ALA synthase

Question 13

Methaemoglobinaemia is

Answer 13

Is a disorder that affects iron in hemoglobin that causes the iron to be in a ferric state rather than a ferrous state

Question 14

Types of haemoglobin

Answer 14

Hb A found in adult with 95% A2 and B2

Hb f and Hb A2 found in fetus with gamma and delta Globin

Question 15

Globin synthesis begins at

Answer 15

3rd week of gestation

Question 16

Globin synthesis takes place in

Answer 16

Poly ribosomes

Question 17

Globin in the fetus is

Answer 17

Gower1, Portland and gower 2

Question 18

Pophyrin is a

Answer 18

Tetrapyrolle structure

Question 19

When haemoglobin is oxygenated, what molecule is pushed out

Answer 19

2,3diphsophoglycerate or 2,3bisphosphoglycerate

Question 20

What are signs medically

Answer 20

What the doctor sees

Question 21

What are symptoms medically

Answer 21

What the patient feels

Question 22

Ph of blood is

Answer 22

7.4

Question 23

Hematocrit

Answer 23

Is the volume of red blood cell in blood expressed in percentage

Question 24

Normal hematocrit value is

Answer 24

45%

Question 25

Plasma forms about _______ percent of blood volume

Answer 25

55%

Question 26

At what stage does fetal haemoglobin becomes adult heamoglobin

Answer 26

3-6month after birth

Question 27

When we inhale fumes from car engines ( carbon monoxide)

Why do we choke up

Answer 27

Haemoglobin has more likeness ( like 100 times) for carbon monoxide than oxygen

Question 28

Carboxy haemoglobin

Answer 28

Heamoglobin with carbon monoxide

Question 29

Haemoglobin is formed at what stage of Erythropoeisis

Answer 29

Polychromaphillic stagev

Question 30

Haemoglobin with carbon dioxide is called

Answer 30

Carbon mono haemoglobin

Question 31

Rate limiting enzyme in heme synthesis

Answer 31

ALA synthase
Aminolevulennic synthase

Question 32

The coenzyme for heme synthesis is

Answer 32

Pyridoxial phosphate vitamin B6

Question 33

Globin synthesis is hemoglobin takes place in

Answer 33

Polyribosome