Haemoglobin Flashcards

1
Q

The main function of red blood cell

A

To carry oxygen to tissues and take co2 from tissues to lungs

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2
Q

What enables the exchange of gases Between RBC and tissue

A

Haemoglobin

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3
Q

Haemoglobin is made up of

A

Protein - Globin ( alpha and beta Globin)

Non protein part- heme

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4
Q

Heme is made up of

A

Iron and porphyrin

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5
Q

The iron in the gene must remain in the _ to do what

A

Ferrous state FE2+ so as to carry oxygen

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6
Q

Hemoglobin with oxygen is called - and why

A

Oxyhemoglobin

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7
Q

Heme is produced where

A

Mitochondrion

Note: matured RBC has no organelle but Immatured RBC HAS before it becomes Remenat called reticulocyte

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8
Q

Hemeoglobin has how many iron

A

4 iron used to carry the oxygen

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9
Q

Norman heamoglobin consist of how many polypeptide chain which are

A

2 alpha and 2 beta chain with its own heme group

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10
Q

A coenzyme in the synthesis of heme is

A

Pyridoxial phosphate B6

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11
Q

Heme is gotten from

A

Succinyl coa and glycine

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12
Q

What enzyme is responsible for heme synthesis

A

ALA synthase

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13
Q

Methaemoglobinaemia is

A

Is a disorder that affects iron in hemoglobin that causes the iron to be in a ferric state rather than a ferrous state

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14
Q

Types of haemoglobin

A

Hb A found in adult with 95% A2 and B2

Hb f and Hb A2 found in fetus with gamma and delta Globin

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15
Q

Globin synthesis begins at

A

3rd week of gestation

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16
Q

Globin synthesis takes place in

A

Poly ribosomes

17
Q

Globin in the fetus is

A

Gower1, Portland and gower 2

18
Q

Pophyrin is a

A

Tetrapyrolle structure

19
Q

When haemoglobin is oxygenated, what molecule is pushed out

A

2,3diphsophoglycerate or 2,3bisphosphoglycerate

20
Q

What are signs medically

A

What the doctor sees

21
Q

What are symptoms medically

A

What the patient feels

22
Q

Ph of blood is

23
Q

Hematocrit

A

Is the volume of red blood cell in blood expressed in percentage

24
Q

Normal hematocrit value is

25
Plasma forms about _______ percent of blood volume
55%
26
At what stage does fetal haemoglobin becomes adult heamoglobin
3-6month after birth
27
When we inhale fumes from car engines ( carbon monoxide) Why do we choke up
Haemoglobin has more likeness ( like 100 times) for carbon monoxide than oxygen
28
Carboxy haemoglobin
Heamoglobin with carbon monoxide
29
Haemoglobin is formed at what stage of Erythropoeisis
Polychromaphillic stagev
30
Haemoglobin with carbon dioxide is called
Carbon mono haemoglobin
31
Rate limiting enzyme in heme synthesis
ALA synthase Aminolevulennic synthase
32
The coenzyme for heme synthesis is
Pyridoxial phosphate vitamin B6
33
Globin synthesis is hemoglobin takes place in
Polyribosome