Recall Deck 5 (2018) Flashcards

1
Q

Parent divorced. What could be 5 negative outcomes for the child as an adult?

A

Many studies found that children of divorced families experienced lower levels of well-being regardless of scholastic achievement, conduct, psychological development, self-esteem, social competence, and relationships with other children (Gov’t Canada)
Loses time with each parent
Child may lose economic security
Child may lose emotional security
Child may have decreased social/psychological maturation
Child may change outlook on sexual behaviour
Child may lose cognitive/academic stimulation
May be less physically healthy
May have higher risk of emotional distress

Government of Canada:
https://www.justice.gc.ca/eng/rp-pr/fl-lf/divorce/2004_1/p2.html#:~:text=Many%20studies%20found%20that%20children,and%20relationships%20with%20other%20children.
Article (2014) )https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240051/

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2
Q

Adolescent boy with autism, what are 2 risk factors for suicidal behaviour apart from depression?

A

-poor emotional regulation skills
- psychiatric comorbidities (intellectual disability – concreteness)
- bullying
-high functioning ASD
- deficits in expression of feelings/thoughts
-abuse
-prior suicide attempts – lethality
https://pubmed.ncbi.nlm.nih.gov/24713024/

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3
Q

Adolescent boy with autism, what are 2 risk factors for depression?

A

Higher cognitive functioning
Self-awareness of ASD deficit
Capacity of introspection
Stressful life events
Quality of social relationships and alexithymia
https://pubmed.ncbi.nlm.nih.gov/26413564/

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4
Q

Teen in rural community with only nurse practitioner. Psychosis. Delusions about mother. Younger sibling in house. Punched the wall. Delusions in the stomach and was going to cut something out of stomach. Dad and younger brother bring him in for assessment. List 5 things that indicated the need for acute inpatient admission/treatment?

A
  • Safety concerns for self
    -meets criteria for involuntary admission under the BC MHA?
  • Limited insight
  • Safety for others – punching wall/delusions about mother – evidence of aggression
  • Limited resources in community – limited access to provider
  • limited access to mental health trained gatekeepers
  • limited access to mental health specialist
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5
Q

Two medications with evidence for OCD?

A
  • fluvoxamine
    -sertraline-POTS study in pediatric OCD
  • clomipramine—first med to have evidence in pediatric OCD
  • would we like to include SSRIs in here too? – i.e. fluoxetine
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6
Q

Name one treatment for mild/moderate OCD?

A
  • CBT - ERP
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7
Q

What are 2 comorbidities with OCD that reduce the response to treatment: -

A
  • OCPD
    -ADHD? MDD?

especially MDD

Major Depressive Disorder (MDD):
Comorbid MDD in OCD patients is associated with:
Lower treatment response rates
Lower remission rates
Greater symptom severity and chronicity
Higher number of hospitalizations
More frequent aggressive obsessions
Higher number of suicide attempts

Post-Traumatic Stress Disorder (PTSD):
Having primary OCD with comorbid PTSD has been found to decrease treatment response rates.

Generalized Anxiety Disorder (GAD):
OCD with comorbid GAD was shown to increase dropout rates and decrease treatment response.

Bipolar Disorder (BD):
Comorbid BD in OCD patients is associated with:
More complex pharmacological interventions required
Higher rates of certain obsessions and compulsions
More frequent hospitalizations
Higher rates of suicidal thoughts and attempts

Attention-Deficit/Hyperactivity Disorder (ADHD):
The presence of ADHD was related to lower treatment response rates in children and adolescents with OCD.

Disruptive Behavior Disorders:
In children and adolescents with OCD, comorbid disruptive behavior disorders were associated with:
Lower treatment response rates
Lower remission rates
In general, patients with one or more comorbid diagnoses tend to have lower treatment response and remission rates compared to those without comorbidities.

The number of comorbid conditions is negatively related to treatment outcome, meaning that more comorbidities are associated with poorer response to treatment.
It’s important to note that the impact of comorbidities on OCD treatment can vary, and some studies have shown mixed results. Comprehensive clinical evaluation and tailored treatment approaches are crucial for managing OCD with comorbid conditions.

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8
Q

Haitian origin 14 year old, OCD, started on fluoxetine 30mg and added Risperidone 0.5mg BID added. Has Tremor and agitation etc. What are two pharmacodynamics/kinetic reasons for these effects.

A
  • CYP 2D6 interaction – risperidone increased through the inhibition of CYP2D6 by fluoxetine.
  • Could also be EPS from risperidone – rule out serotonin syndrome

Research on older tricyclic antidepressants found that African Americans were more likely to carry alleles that slow drug metabolism, potentially leading to higher blood levels and greater risk of side effects.
However, studies on SSRIs like paroxetine, sertraline, and fluoxetine found no racial or ethnic group differences in drug response related to these genetic variants.

Tardive Dyskinesia
There is some evidence that African Americans may be more susceptible to tardive dyskinesia (involuntary movements) from antipsychotics compared to white patients.
Other Side Effects
African Americans may be more likely than whites to gain weight while taking atypical antipsychotics.
One study found that African Americans had a higher rate of discontinuation of antipsychotic medication, possibly due to side effects.

Some researchers have suggested there may be ethnic differences in the pharmacodynamics or pharmacokinetics of antipsychotics that could explain the higher incidence of certain adverse events in Afro-Caribbean populations.

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9
Q

Same stem…mom says that meds won’t work and symptoms are because of passion/spiritual. What are some cultural reasons for refusing treatment? What could you explore with her?

A

Cultural Stigma and Beliefs
Perception of Mental Illness
In many Afro-Caribbean cultures, there is significant stigma surrounding mental health issues. Mental illness is often viewed as:
A sign of personal weakness
A moral failing
Something to be ashamed of and hidden from others
This stigma can prevent individuals from acknowledging mental health problems and seeking help.
Spiritual and Religious Interpretations
Mental health issues are frequently attributed to:
Evil spirits or demonic possession
Punishment for sins or moral transgressions
A lack of faith or commitment to God
These beliefs can lead people to seek help from religious leaders or folk practitioners rather than mental health professionals.
Distrust of Medical Systems
Historical Context
There is often a deep-seated mistrust of medical and mental health systems among Afro-Caribbean communities, stemming from:
A history of unethical medical experimentation on Black populations
Experiences of racism and discrimination in healthcare settings
This mistrust can make individuals reluctant to engage with formal mental health services.
Cultural Competence Concerns
Many Afro-Caribbean individuals worry that mental health professionals may:
Lack understanding of their cultural background and experiences
Misinterpret normal cultural behaviors as symptoms of mental illness
Provide treatment that is not culturally appropriate or effective
Community and Family Dynamics
Collectivist Culture
Afro-Caribbean cultures tend to be collectivist, emphasizing:
Family honor and reputation
The impact of individual actions on the entire community
A mental health diagnosis may be seen as “contaminating” not just the individual, but the extended family and community.
Privacy and Self-Reliance
There is often a strong emphasis on:
Keeping family matters private
Solving problems within the family or community
Self-reliance and “toughing it out”
These values can discourage seeking outside help for mental health issues.
Alternative Help-Seeking Behaviors
Instead of formal psychiatric treatment, Afro-Caribbean individuals may prefer to:
Seek guidance from religious leaders or community elders
Use traditional healing practices or folk remedies
Rely on family support and prayer
These alternatives are often seen as more culturally acceptable and less stigmatizing than psychiatric treatment.
By understanding these cultural factors, mental health professionals and policymakers can work towards developing more culturally competent and accessible mental health services for Afro-Caribbean communities.

role of voudu:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880247/

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10
Q

Ethnic minority experience barriers to treatment. List reasons that limit access. Name 2 reasons MH treatment might be less effective with an ethnic minority youth (reduced response)

A

-poverty – access to ethnically based care/cost
- racism – barrier to youth interacting with care as well as receiving care

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11
Q

. List 5 pharmacokinetic or pharmacodynamics differences between MPH and dextroAmphetamine?

A

MPH increases clonidine levels
Amphetamine interacts with fluoxetine/paroxetine -2D6
Dopamine reuptake inhibitor
Amphetamine – more stimulant; vesicles add more into the cleft

  1. amphetamines have: (a) MAO inhibition, (b) are CYP 2D6 substrates, and (c) inhibit VMAT-2–> increase levels of dopamine and NE in synaptic cleft through both reuptake inhibition AND vesicle release
  2. methylphenidate–> (a) serotonin receptor 1A agonist, (b) inhibitor of 1A2, (c) redistribution of VMAT-2
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12
Q

MPH and cocaine – differentiate:

A

Methylphenidate does not have the same abuse liability as cocaine due to slower dissociation from the site of action, slower uptake into the striatum, and slower binding and dissociation with the dopamine transporter protein relative to cocaine [144]. However, it is important to remember that the route of administration may alter the abuse liability of a substance. The oral administration of psychostimulants has been shown to decrease the likability of a substance while parenteral usage (injected, snorted) has been shown to be associated with euphoria [144]. Individuals with ADHD and either SUD or CD are at highest risk for diversion and misuse and are more likely to both misuse and divert their stimulant medication [145]. Both immediate-release and, to a lesser degree, extended-release preparations of stimulant medications can be diverted or misused, with extended release preparations having less potential for parenteral usage [55, 145]. Nonstimulants such as atomoxetine and guanfacine XR do not have abuse potential.

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13
Q

Kid with anxiety and side effects and you switch to another SSRI. What are some ways to switch between two SSRI/meds of the same class? What are some possible consequences of the stopping (or switching we can’t remember)

A

Titration down and then start new med with titration up
- Cross-titration of medications
- consequences of switching – could improve! Could deteriorate with new medication; could deteriorate if no treatment (stop and switch method); could have adverse reactions (allergic reaction, side effects of medication)

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14
Q

Conduct disorder, no ADHD. List the components of the lacking prosocial emotion specifier?

A

This specifier is labeled “with Limited Prosocial Emotions” (LPE) and is used when children exhibit at least 2 out of 4 criteria over at least 12 months, and in multiple relationships and settings: (1) lack of remorse or guilt; (2) callous- lack of empathy; (3) unconcerned about performance; and (4) shallow or deficient affect.
https://www.sciencedirect.com/science/article/pii/S0890856720319857#:~:text=This%20specifier%20is%20labeled%20%E2%80%9Cwith,%3B%20and%20(4)%20shallow%20or

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15
Q

Child born in shelter, parents in shelter, mom partied during pregnancy. Child has facial FAS features, behavioural issues, conduct type symptoms. List 5 possible diagnosis. List perinatal/environmental risk factors for ADHD

A

o ASD
-ADHD
-Reactive Attachment Disorder
-Parent/child relational issue
-PTSD
- Not sure of age but: MDD, ODD, Conduct, Substance Use

Perinatal risk factors:
Low birth weight
Smoking in pregnancy
Advanced parental age
Prematurity
ACE Family history

Prenatal – very low BW (<1.5kg) 2-3X ↑, ↑ maternal stress, tobacco/EtOH/drugs/toxin exposure.
Postnatal – neonatal anoxia, CNS infxn, severe head injury, exposure to lead/toxins.
Psychosocial – ACEs, early severe deprivation, parenting influences outcome (may ∆ threshold to bring pt to Rx).
Personal – ↓ behavioural inhibition/effortful control/constraint, -ve emotionality, ↑ novelty seeking.

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16
Q

Kids in therapy. List 5 ways that kids express resistance in therapy.

A
  • Not showing up
  • Shows up late
  • Not doing homework
  • Not making eye contact
  • Not talking
  • Tantrums
  • Agreement with everything
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17
Q

Kid does not have mental illness. But has mild delay, failed grade 8, repeat offences. Lawyer asks you for assessment. What are 5 things you would assess to determine competency to stand trial?

A

Can the kid state what the charge is? They don’t have to understand
Does the kid understand people think they did the crime?
Does the child understand the consequences of being found guilty/not guilty (is this true or is it more for the effects of the crime?)
Do they understand the roles of each person?
Child needs to be able to communicate with their counsel

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18
Q

Girl doing therapy, cluster b, doing well. On weekend she had broken up with boyfriend, drank, cut and skipped school. She’s late and mom fills you on all this. She shows up and wants to talk about her emotions. List 5 components that you could address to make this session effective today.

A
  • Check if suicidal currently/current plan
  • Discuss safety concerns – cutting
  • Discuss safety concerns – drinking
  • Identify coping skills used prior to cutting/drinking – commend
  • Review safety plan
  • Validate emotional distress over difficult feelings
  • Address that she is late
    *Need to review how to do DBT with patients
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19
Q

Kid with head injury. Had 2 head injuries in the past 3 years. Also had a past depressive episode and treated with meds. Not on meds now. Hospitalized for 24 hours. What 3 things would you monitor in post concussive disorder or what are the psych symptoms to monitor for post concussion? What are the risk factors for developing another depressive episode

A
  • headache, vision changes, nausea
  • sleep (MDD), eating (post-concussive/MDD), concentration (post-concussive, MDD), mood, aggression
    Risk factors: Neuroticism, previous MDD, severity of previous episodes/current, family history, head injuries, comorbid psychiatric illnesses, ACEs, comorbid medical conditions, substance use
    (GO LOOK AT CANMAT)
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20
Q

Eating disorder. What are 3 differences between AN and ARFID. List 3 etiologies of ARFID.

A

ARFID does not have distortion of body image
ARFID does not restrict with intent of losing weight
ARFID may have a normal BMI

Etiologies of ARFID:
Neurodevelopmental disorder – ASD
Trauma/neglect
OCD

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21
Q

Depression. List factors of an episode that increase risk of recurrence.

A
  • Severity
  • Previous episodes
  • Neuroticism
  • Comorbid Psychiatric illness
  • Family history
  • Substance use
  • Comorbid medical conditions
  • Previous head injuries
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22
Q

School refusal. 21a. What is your treatment approach (nonpharm) for school refusal

A

History, collateral from parents and school
Screen for precipitating factors - bullying, abuse, safety and substance use
- Screen for perpetuating factors – learning disorders, adhd, asd, anxiety, depression
- Motivational interviewing/involve the child in the plan to return; focus on return to school either immediate or gradual – need a team meeting with school, family and child with clear communication of plan plus timely follow-up

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23
Q

How can a teacher help a child with test anxiety?

A
  • More time; separate room
  • See where ethe struggles are (teacher meets with them)
  • see what the student thinks would be helpful
  • breaks in the test itself
  • do you need headphones/fidget gadget
  • do on a computer/verbally etc.
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24
Q

How can a teacher help a kid with anxiety about doing large projects?

A

IEP with focus on breaking down large problems into smaller problems. Mentorship on doing this with a large project; could also include connection to a team (group project) with individually assigned tasks
- involvement of parents/EA
- regular check-ins

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25
Q

Psychosis and school accommodation. 22a. Name 1 way a guidance counsellor can help a school who has a student with schizophrenia:

A
  • Develop an IEP; run interference with individuals (such as teachers) who do not understand diagnosis (reduce stress)
  • Arrange for times when the student can meet with a case worker through EPI or attend medical appointments
  • Help arrange times to take medications with the school nurse
    -adjst IEP based on neurocog deficits from SCZ ie eexec fxn, processing speed, working memory
26
Q

Name 2 strategies you would tell a teacher who has a student with auditory hallucinations?

A
  • Create a system where the student can signal that they are hearing auditory input and the teacher can validate whether that input is from them or not
  • Create a plan where the student can signal that they need some alone time and can communicate that to the teacher without drawing peer attention
  • Allow wearing noise cancelling headphones in classroom while working during quiet self-study time

Teachers can provide valuable support to students experiencing auditory hallucinations in several ways:
Classroom Accommodations
Seating Arrangements:
Offer preferential seating away from distracting noises or peers that may exacerbate symptoms. This can help the student focus better on classroom activities.
Note-Taking Assistance:
Provide class notes or allow audio recording of lessons to help the student stay focused on relevant information, as hallucinations may interfere with attention.
Extended Time:
Allow extra time for completing exams and assignments, as hallucinations can be distracting and antipsychotic medications may have sedating effects.
Instructional Strategies
Flexible Deadlines:
Offer flexibility with assignment due dates, especially for complex projects, as symptoms can fluctuate over time.
Alternative Assessments:
Consider alternatives to public speaking assignments, such as recorded presentations or one-on-one with the teacher, to reduce stress that may worsen symptoms.
Organizational Support:
Help the student organize homework, review assignment logs, and maintain home-school communication to ensure tasks are completed.
Emotional Support
Safe Spaces:
Identify safe spaces within the school where the student can go if feeling overwhelmed.
Breaks:
Allow the student to take breaks as needed to manage symptoms.
Open Communication:
Maintain open lines of communication with the student and their family to better understand and address their unique needs.
Collaboration
Work with Support Team:
Collaborate with the student’s mental health providers, parents, and school support staff to create a comprehensive support plan.
Educate Yourself:
Learn about psychosis and its symptoms to better understand the student’s experiences and needs.
Remember, each student’s experience with auditory hallucinations is unique. It’s crucial to tailor support strategies to the individual student’s needs and maintain a compassionate, understanding approach. By creating a supportive classroom environment, teachers can play a vital role in helping students manage their symptoms and succeed academically.

27
Q

Name 2 strategies that you would tell a teacher for a student with schizophrenia with social isolation

A
  • Encourage attendance to school?
  • Encourage participation in groups/clubs
  • Psychoeducation for the teacher on negative symptoms so attention is not drawn to the student by the teacher
28
Q
  1. Teen with an addiction to cocaine. Name 5 strategies you would use in family therapy? (ie psychoeducation, connections to community supports) *REPEAT QUESTION
A

Psychoeducation
Motivational Interviewing
Emotional regulation skills
Validation
Communication

29
Q
  1. Kid not doing well in school. Difficult in reading and verbal, not spelling well, can’t organize paragraphs, not wanting to do homework at home. Most likely diagnosis? 2 Common comorbidities to rule out? *REPEAT QUESTION 2017 EXAM
A

o Most likely diagnosis: Specific Learning Disorder in reading and writing
- 2 common comorbidities: Language Disorder, ADHD

30
Q

2 metabolic/CV (cant remember) consequences CV risk factors for an atypical? What 3 would you *REPEAT QUESTION EXAM 2017

A

Patients on atypical antipsychotics should have their weight monitored monthly in the first 3 months and every 3 months thereafter. Blood pressure, fasting glucose and lipid profile should be assessed at 3 and 6 months, and yearly thereafter. Children under 10 years of age, seniors, medically ill patients, and patients on combination treatments should receive more frequent monitoring.

“Valproate products (valproic acid, divalproex sodium) should not be used in female children, in female adolescents, in women of childbearing potential and pregnant women unless alternative treatments are ineffective or not tolerated because of its high teratogenic potential and risk of developmental disorders in infants exposed in utero to valproate

31
Q

Factors in depression that increase risk of bipolar disorder? *REPEAT QUESTION 2019 EXAM

A

*REPEAT QUESTION 2019 EXAM Earlier age of illness onset
Highly recurrent depressive episodes
Family history of BD
Depression with psychotic features
Psychomotor agitation,
Atypical depressive symptoms such as hypersomnia, hyperphagia, and leaden paralysis
Postpartum depression and psychosis
Past suicide attempts
Antidepressant-induced manic symptoms
Rapid cycling (CANMAT BP Guidelines)

32
Q
  1. Kid with nightmares after fire next door 5 days ago. Has Acute stress disorder. What 3 symptoms would you monitor for other than nightmares?
A

Children specific:
- Repetitive play with themes of traumatic event (age 6 and lower)
- Dissociative reactions during play (trauma-specific reeneactment during play) (age 6 and lower)
- Separation anxiety in children – may appear is needing more attention from caregivers (DSMV 283-284)
-may avoid reminders of trauma or may become preoccupied with aspects of trauma (may talk about dogs incessantly after being bitten but still avoids dogs)

Other that could relate to child (basically all of the criteria)
- Intense or prolonged distress or marked physiological reactions to internal/external cues that symbolize/resemble aspect of traumatic events
- Dissociative symptoms
- Negative mood
- Avoid external reminders of event – people/place/thoughts
- Arousal symptoms - Sleep issues, irritability

33
Q

Kid with enuresis. 2 meds? 3 non-pharm besides already voiding before bed? + typical course

A

Medications:
Desmopressin Acetate - (DDAVP) (nasal spray are nasal discomfort, nosebleeds, tummy pain, and headache. The only serious side effect noted in children treated with DDAVP is seizure due to water intoxication)
Imipramine (Tricyclics in general) - Complete dryness has been reported in 10-50% of patients; not used to treat bed-wetting in children younger than 6 to 7 years of age (National Kidney Foundation) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100585/

Non-pharmacological management:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100585/
Enuresis alarm therapy
Simple Behavioural therapy– retention control training, fluid deprivation, lifting, random wakening, star charts
Complex behavioural and educational interventions – scheduled wakening, dry bed training, full spectrum home training)

34
Q

Separation anxiety question. What are common comorbidities?

A

Children: GAD and Specific Phobia (DSMV pg 195)
In adults: Specific phobia, PTSD, Panic disorder, GAD, Social anxiety disorder, agoraphobia, OCD and personality disorder, depressive and bipolar disorders

35
Q

3 ways CBT is different in kids?

A
  • Parental psychoeducation - Focus on behavioural techniques
  • Heavy parental involvement
  • Concrete examples if doing any cognitive work
  1. use play–> role play, puppets
  2. modeling–> allow kids to learn by imitation
  3. make concepts more simple, more concrete so kids can understand
  4. parental involvement–> behavioural focus
36
Q

Explain one aspect of systems theory:

A

The whole is greater than the sum of its parts.
Is this referring to one of the six underlying assumptions?

The whole is greater than the sum of its parts - systems theory emphasizes looking at the entire system rather than just individual components.

Systems are dynamic and interconnected - changes in one part of a system affect other parts and the system as a whole.

Systems seek homeostasis - there is a tendency towards stability and balance within systems.

Circular causality - cause and effect relationships are seen as cyclical rather than linear.

37
Q

Name the components of the McMaster Model of family therapy:

A

The McMaster Model of Family Functioning includes six key components:

Problem Solving: This dimension assesses the family’s ability to resolve both instrumental (e.g. money management, food provision) and affective (emotional) problems.

Communication: This examines how information is exchanged within the family, focusing on whether it is clear vs. masked and direct vs. indirect.

Roles: This looks at how the family allocates responsibilities and handles accountability for family functions like providing resources, nurturance and support, and life skills development.

Affective Responsiveness: This evaluates the family’s capacity to respond to a range of stimuli with appropriate quality and quantity of feelings.

Affective Involvement: This assesses the extent to which family members are interested in and place value on each other’s activities and concerns.

Behavior Control: This dimension examines the patterns the family adopts for handling behavior in different situations.

The model views the family as an interrelated system, emphasizing that all parts of the family are interconnected and cannot be fully understood in isolation. It provides a structured approach to assessing family functioning across these six dimensions, which can be used to guide family therapy interventions.

Based on Systems Theory which has underlying assumptions as below:
1 All parts of the family are interrelated.
2 One part of the family cannot be understood in isolation from the rest of the family system.
3 Family functioning cannot be fully understood by simply understanding each of the individual family members or subgroups.
4 A family’s structure and organization are important factors that strongly influence and determine the behaviour of family members.
5 The transactional patterns of the family system strongly shape the behaviour of family members.
We focus on assessing and formulating six dimensions of family life: problem-solving, communication, roles, affective responsiveness, affective involvement, and behaviour control. There is also: dysfunctional transactional patterns

Administer a Family Assessment Device – looks at the six dimensions and overall functioning

38
Q

ADHD, 5 things to as about when doing CV assessment before starting stimulants?

A

*REPEAT QUESTION 2016 EXAM
- Personal history of cardiac concerns – LV function, valvular abnormalities, sudden LOC
- Family history of cardiac concerns – sudden death, hx of MIs/valvular and hypertrophy
- Blood pressure/Heart rate abnormalities
- Physical exam
- any current symptoms

39
Q

ADHD, sleep disruption with stimulants. 3 nonpharma interventions? 2 pharma interventions to do with the stimulant?

A

Non-pharmacological Options
Decrease the dosage of stimulant
Give stimulant earlier in day
Implement sleep hygiene skills

Pharmacological Options:
Change stimulant to a shorter acting one until they can tolerate a longer-acting stimulant
Add melatonin
Add an alpha agonist as an adjunct at night

40
Q

3 medical conditions associated with ASD?

A
  • Epilepsy
    -Sleep problems
    Constipation
  • straight out of DSMV pg 59
41
Q

22q11 which cognitive function is not affected? What are the psychiatric disorders?

A

Preserved verbal IQ and verbal memory – language is relatively preserved
Schizophrenia
ASD
ADHD
Anxiety
Learning Disorders

42
Q

There were comorbidities questions…..we can’t remember. Maybe the Conduct disorder he doesn’t have ADHD but what could his comorbidities be?

A

ADHD (worse outcome)
ODD (worse outcome)
Specific learning disorder
Anxiety disorders
Depressive disorder
Bipolar disorder
Substance-related disorder

43
Q

How does cannabis work? What are 2 pharmacodynamic/kinetic properties? Explain 3 things about cannabis and link to psychosis?

A

Cannabis leaves and flowers have a resin containing unique molecules called cannabinoids. There are more than 60 types of cannabinoids, but the best known, and the one with the most significant psychoactive effect, is commonly called THC (delta-9-tetrahydrocannabinol). When cannabis is inhaled, chemicals called cannabinoids are absorbed through the lungs and into the bloodstream, producing almost immediate effects which generally last a few hours. When swallowed, cannabinoids are absorbed through the stomach and intestine. This process takes longer. It makes it more difficult for the user to carefully manage the dose, since it takes to be felt, and effects are stronger and last much longer. The effects of cannabis can be very different for different people. One person may feel relaxed, another full of energy, and another anxious. Sometimes the same person will have a different experience on a different occasion. A lot depends on the type and amount of cannabis we use at a given time. Other factors that affect how you respond include: past experiences with cannabis use, present mood and surroundings, plant strain and your biochemistry, mood or mindset, mental and physical health, and diet. (drugcocktails.ca)
Whereas THC is a partial agonist at the CB1 and CB2 receptors in the endogenous cannabinoid system and exerts its psychoactive and pain modulatory effects via CB1 agonism, CBD has relatively little affinity for the orthostatic sites of these receptors 6, 13 and may inhibit THC binding at CB1 receptors via another mechanism. CBD is also reported to bind to other noncannabinoid receptors

Pharmacodynamic/kinetic properties of Cannabinoids (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177698/)
Pharmacokinetics is the study of what the body does to the drug, and Pharmacodynamics is the study of what the drug does to the body.

Pharmacokinetics and the effects observed with cannabis medicines depend on the formulation and route of administration (ADME)
Availability:
Cannabinoids administered via inhalation exhibit similar pharmacokinetics to those administered intravenously 20. After inhalation, peak plasma concentrations of both THC and CBD are attained rapidly (within 3–10 min) 20, 21 and maximum concentrations are higher relative to oral ingestion. The bioavailability of THC after inhalation reportedly ranges from 10% to 35% 20, attributable to variability (both intra‐ and intersubject) in inhalational characteristics (number, duration and interval of puffs, breath hold time, inhalation volume), inhalational device 17, 23, size of inhaled particles and site of deposition within the respiratory system 17. Inhaled CBD was reported to have an average systemic bioavailability of 31%, and a plasma concentration–time profile similar to that of THC

THC and CBD are both highly lipophilic and have poor oral bioavailability (estimated to be as low as 6%) 26, 27. Oral THC formulations exhibit variable absorption and undergo extensive hepatic first‐pass metabolism 28, resulting in lower peak plasma THC concentration relative to inhalation 29 and a longer delay (~120 min) to reach peak concentration 20, 30. Following oral administration of CBD, a similar plasma concentration–time profile to that of oral THC has been observed 20. Based on this profile, oral formulations may be useful for patients requiring symptomatic relief over a longer period.
Transdermal administration of cannabinoids avoids first‐pass metabolism but their extremely hydrophobic nature limits diffusion across the aqueous layer of the skin 31. Effective skin transport can only be obtained by permeation enhancement 32.

Distribution
Cannabinoids rapidly distribute into well‐vascularized organs (e.g. lung, heart, brain, liver) 26, 29, 36, with subsequent equilibration into less vascularized tissue 36. Distribution may be affected by body size and composition, and disease states influencing the permeability of blood–tissue barriers 37.
With chronic use, cannabinoids may accumulate in adipose tissues 22, 38. Subsequent release and redistribution 22 (e.g. in the context of weight loss) 39 may result in the persistence of cannabinoid activity for several weeks post‐administration 23, 26, 40, 41.
The volumes of distribution (Vd) of CBD and THC are high [respectively, Vdβ ~32 l kg–1 (calculated following intravenous administration) 21 and Vdss 3.4 l kg–1 (calculated following inhaled administration)].

Metabolism
The metabolism of THC is predominantly hepatic, via cytochrome P450 (CYP 450) isozymes CYP2C9, CYP2C19 and CYP3A4. THC is mainly metabolized to 11‐hydroxy‐THC (11‐OH‐THC) and 11‐carboxy‐THC (11‐COOH‐THC), which undergoes glucuronidation 42 and is subsequently excreted in the faeces and urine 26, 28. Metabolism also occurs in extra‐hepatic tissues that express CYP450, including the small intestine and brain 22. The metabolite 11‐OH‐THC is reported to have psychoactive activity 43.
Importantly, lipohilic THC is able to cross the placenta 30 and is excreted in human breast milk 44 – raising concern for toxicity to the developing brain.
CBD is also hepatically metabolized, primarily by isozymes CYP2C19 and CYP3A4 and additionally, CYP1A1, CYP1A2, CYP2C9 and CYP2D6 45. After hydroxylation to 7‐hydroxy cannabidiol (7‐OH‐CBD), there is further hepatic metabolism and subsequent faecal, and, to a lesser extent, urinary, excretion of those metabolites 26.
Little is known about the pharmacological activity of the metabolites of CBD in humans.

Elimination
Estimates of the elimination half‐life of THC vary 20. A population pharmacokinetic model has described a fast initial half‐life (approximately 6 min) and long terminal half‐life (22 h) 47, the latter influenced by equilibration between lipid storage compartments and the blood 37.
A relatively longer elimination half‐life is observed in heavy users 18, attributable to slow redistribution from deep compartments such as fatty tissues 18, 19. Consequently, THC concentrations >1 μg l–1 may be measurable in the blood of heavy users more than 24 h following the last cannabis use 18, 48, 49.
CBD has also been reported to have a long terminal elimination half‐life, with the average half‐life following intravenous dosing observed to be 24 ± 6 h and post‐inhalation to be 31 ± 4 h 21. An investigation of repeated daily oral administration of CBD elicited an elimination half‐life ranging from 2 to 5 days 50.

Pharmacodynamics
Cannabis produces sedation, and significant pharmacodynamic interactions may occur if it is administered with other CNS depressant drugs
Cannabis use is associated with both pathological and behavioural toxicity
THC produces dose‐dependent performance impairment
In healthy volunteers, administration of THC produced psychotic symptoms, altered perception, increased anxiety and cognitive deficits 68. Cannabinoids may induce tachycardia 69, probably via direct agonism of CB1 receptors in cardiac tissue

In healthy volunteers, administration of THC produced psychotic symptoms, altered perception, increased anxiety and cognitive deficits 68
https://www.cpa-apc.org/wp-content/uploads/Cannabis-Academy-Position-Statement-ENG-FINAL-no-footers-web.pdf
* The endocannabinoid system plays a role in this brain maturation and thus exogenous cannabinoids from cannabis can affect this process directly in a negative way
* Early and regular use increases the risk of developing a primary psychotic illness in those individuals who are vulnerable. Vulnerability factors are not currently clear, but may include factors such as childhood trauma and genetics. In those young adults who have developed psychosis, continued cannabis use worsens long-term symptom and functional outcomes
Cannabis may increase the risk of depression and early regular use is associated with younger age of onset of symptoms of psychosis and of bipolar disorder.

44
Q

Foster Care child. What do you need to know before you prescribe medication or maybe what is part of your assessment?

A

Diagnostic clarity

Who is the guardian? Is there consent from the guardian
Cost – who is paying
Who is monitoring
Ability of the foster family to bring child back for follow-up on medication side effects
Family history availability for adverse reactions
Past medical history for any contraindications including allergies or worsening of other conditions
Current medications – data available for drug interactions
Ability of family to help the child take the medication – if it is something that has a discontinuation effect (e.g. SSRI or alpha 2 agonists), then it needs to be monitored

45
Q

Reactive attachment disorder. Some reason we remember that you had to rule out ASD and also that you had to say reasons why they could develop reactive attachment disorder maybe? *REPEAT QUESTION

A

You would have to comment that this could be ASD – justify then why you would consider RAD – probably a vignette. This child was raised without an attachment feature and now has these features.

46
Q

3 Difference in child vs adult anxiety.

A

Infants typically experience fear of loud noises, fear of being startled, and later a fear of strangers. Toddlers experience fears of imaginary creatures, fears of darkness, and normative separation anxiety. School-age children commonly have worries about injury and natural events (e.g., storms). Older children and adolescents typically have worries and fears related to school performance, social competence, and health issues
AACAP
3+ for adults of 6
1+ for children of 6

Lecture
Children will cry more, tantrums and present with more physical symptoms. They may not always recognize that their fear is unrealistic or excessive
The content may be different. Threshold for diagnosis is lower.

47
Q

Stomach aches on Sunday night. Dx separation anxiety. What are 2 other diagnosis.

A

Environmental stressors – bullying, trauma
Medical concerns
GAD
Panic disorder
Depression
Somatic Symptom disorder
Adjustment Disorder with anxious features

48
Q

Name 5 things you would say to a teen/ mom with ADHD about the risk/ management of driving:

A

Untreated ADHD associated with higher risk of MVAs
Treating ADHD decreases the risk of MVAs
Make sure they have their license in the car
Make sure they understand no substance use while driving
No using your phone while driving/distracted driving
Making sure they wear their seatbelt
Do they know how many people they can have in the car/rules of the road
Driving in a state where they are not emotionally labile is recommended
Minimize distractions while driving
No other teens in the car
https://chadd.org/for-parents/teens-with-adhd-and-driving/

49
Q

Kid with ADHD, stealing + violence. What are two possible comorbidities that this could be:

A

Conduct Disorder
ODD
FASD
IED
Kleptomania
Intellectual Disability

50
Q

Kid with ASD + aggression, name one pharmacological treatment:

A

Risperidone or aripiprazole

51
Q

Name 3 pharmacological strategies for a patient with separation disorder?

A

SSRI – fluoxetine, fluvoxamine, sertraline (pg 41 of Katzmann Anxiety)
Buspirone AACAP recommendations
Benzos AACAP recommendations

Katzmann – Separation Anxiety specific
Citalopram – level 4 evidence
Adj imipramine

52
Q

Name 3 nonpharmacological strategies for patient with separation disorder?

A

CBT
Psychoeducation
Mindfulness
goal-setting, breathing techniques, visualization, and mindfulness to decrease emotional distress and self-defeating behaviour

If no CBT available:
educational support (provide supportive treatment and educate the child and family about anxiety disorders) and psychoeducation based on CBT principles, parent training (guidance to establishing a structured program for monitoring anxious behavior in the home that includes setting up expectations, rewards, and contingencies) and case management support that includes contact with the school. The child and family may also be encouraged to read about childhood anxiety disorders and interventions with CBT

Interventions that improve parent-child relationships, strengthen family problem solving, reduce parental anxiety, and foster parenting skills that differentially reinforce adaptive coping and appropriate autonomy in the child are often incorporated into a range of psychotherapeutic interventions with anxious children

High maternal emotional overinvolvement appears be connected with SAD in at-risk children, and maternal criticism and control may be associated with childhood anxiety

53
Q

five components of CBT for childhood anxiety disorders:

A

psychoeducation with child and parents about the illness and CBT, somatic management skills training (e.g., relaxation, diaphragmatic breathing, self-monitoring), cognitive restructuring (e.g., challenging negative expectations and modifying negative self-talk), exposure methods (e.g., imaginal and in vivo exposure with gradual desensitization to feared stimuli), and relapse prevention plans (e.g., booster sessions and coordination with parents and school)

54
Q

. Parent does not want their child to be on stimulant. What other than short + long term benefits can you give them?

A

Or if the question means what other than stimulants could you do to get short term/long-term benefits -non-stimulants
-behavioural
-environmental changes

55
Q

ADHD vignette a. What are two Health Canada warnings on stimulants? b. What 3 things would you monitor at follow-up after starting a kid on stimulants? (e.g. height, weight, BP) ? Health Canada warnings on stimulants:

A

o Suicide-related events (https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/52759a-eng.php) o Sudden death from CV events (https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2005/14302a-eng.php) o Priapism ? Stimulants and monitoring: o Responses to medications and adverse reactions (i.e., SNAP questionnaire) o HR and BP o Height and weight o Suicidal ideation

56
Q

Motivational interviewing vignette ?? 5 principles of motivational interviewing *REPEAT QUESTION 2016 EXAM

A

rolling with resistance
open ended questions
affirmations
summaries
consolidating comittment
eliciting change talk
developing discrepancy
expressing empathy
reflective listening

57
Q

Cannabis c. 2 physical withdrawal symptoms d. 3 psychological withdrawal symptoms *REPEAT QUESTION 2016 EXAM

A

Cannabis Withdrawal Symptoms a) Two physical ones: Abdominal pain, tremors, sweating, fever, chills or headache b) Three psychiatric ones: 1. Nervousness and Anxiety 2. Irritability or anger 3. Depressed mood 4. Sleep difficulty

58
Q

Trichotillomania - person had alopecia spot and didn’t have OCD, body image issues, or substance issues e. 2 differential diagnoses f. 3 principles of CBT for trichotillomania

A

? Differential diagnosis of trichotillomania (as per DSM V) o Normative hair removal/manipulation o Other obsessive-compulsive and related disorders o Neurodevelopmental disorders (stereotypies and tics) o Psychotic disorder (in response to a delusion or hallucination) o Another medical condition (inflammation of the skin or other dermatological conditions?? skin biopsy or dermoscopy) o Substance-related disorders (stimulants) ? Principles of CBT for trichotillomania o Habit reversal training ?? You learn how to recognize situations where you’re likely to pull your hair and how to substitute other behaviors instead. For example, you might clench your fists to help stop the urge or redirect your hand from your hair to your ear. Other therapies may be used along with habit reversal training. o Cognitive therapy and identifying distorted beliefs in relation to hair pulling o Relaxation techniques o Psychoeducation ? In a typical course of HRT + stimulus control for trichotillomania, patients will: o Try to understand the triggers that cause them to pull their hair; o Develop a competing response that they can do instead of pulling at their hair; o Identify someone in their life who can serve as a support person (or persons) in encouraging them to engage in this alternative response to pulling; o Use stimulus control strategies, which include reducing environmental or behavioral triggers that lead to pulling (e.g., disposing of tweezers, not watching TV, covering areas of the body where one is susceptible to pulling hair), making it more difficult to pull (e.g., using Band-Aids or hats) and/or providing alternative sensory reinforcement (e.g., playing with a Koosh ball).

59
Q

PTSD g. Best treatment for PTSD h. 2 meds with evidence to prevent PTSD i. Alpha agonist used in PTSD for nightmares and insomnia *REPEAT QUESTION 2017 EXAM

A

? Best treatment for PTSD o Medications with evidence to prevent PTSD o Cochrane says no evidence
Katzmann said morphine and propranolol
Medication used in PTSD for nightmares and insomnia o https://www.cochrane.org/CD006239/DEPRESSN_medications-to-prevent-post-traumatic-stress-disorder-ptsd-a-review-of-the-evidence

60
Q

. ADHD and tics a. 4 evidence-based medications to treat ADHD

A

Amphetamines
Methylphenidate
Alpha-agonists
Atomoxetine

61
Q

b. What ADHD medication is relatively contraindicated when tics are present?

A

-stimulants
You would use guanfacine, clonidine, risperidone and aripiprazole for tics in particular