ADHD Flashcards

1
Q

define ADHD

A

A persistent pattern of INATTENTION and/or HYPERACTIVITY/IMPULSIVITY that interferes with functioning or development as characterized by specific symptoms of each

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2
Q

how many symptoms of inattention and/or hyperactivity do you need to meet criteria for ADHD

A

6+ (need at least 6 in one of the two categories, not 6 between the two)

(5+ if older than 17)

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3
Q

what is criterion A for ADHD

A

a persistent pattern of inattention and/or hyperactivity/impulsivity that interferes wtih functioning or development, as characterized by 1) inattention and/or 2) hyperactivity and impulsivity

6+ symptoms required of inattention and/or hyperactivity which have persisted for at least SIX MONTHS to a degree that is inconsistent with developmental level and that negatively impacts directly on social and academic/occupational activities

symptoms are NOT solely a manifestation of oppositional behaviour, defiance, hostility or failure to understand tasks or instructions

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4
Q

how many symptoms are listed under criterion A for inattention? impulsivity?

A

9 for both

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5
Q

list the symptoms of inattention listed in criterion A of the dsm 5

A
  1. often fails to give close attention to details or makes careless mistakes in schoolwork, at work, or during other activities (i.e overlooks or misses details, work is inaccurate)
  2. often has difficulty sustaining attention in tasks or play activities
  3. often does not seem to listen when spoken to directly (i.e mind seems elsewhere, even in absence of any obvious distraction)
  4. often does not follow through on instructions and fails to finish schoolwork, chores, or duties in the workplace (i.e starts tasks but quickly loses focus and is easily sidetracked)
  5. often has difficulty organizing tasks and activities (i.e difficulty managing sequential tasks, keeping materials and belongings in order, messy, poor time management)
  6. often avoids, dislikes or is reluctant to engage in tasks that require sustained mental effort
  7. often loses things necessary for tasks or activities (i.e school materials, pencils)
  8. is often easily distracted by extraneous stimuli (for older kids, may include unrelated thoughts)
  9. is often forgetful in daily activities
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6
Q

list the symptoms of hyperactivity/impulsivity listed in criterion A of the dsm 5

A
  1. often fidgets with or taps hands or feet or squirms in seat
  2. often leaves seat in situations when remaining seated is expected
  3. often runs about or climbs in situations where it is inappropriate (in older kids, may be limited to feeling restless)
  4. often unable to play or engage in leisure activities quietly
  5. often “on the go” acting as if “driven by a motor” (i.e unable to be or is uncomfortable being still for extended periods as in restaurants, meetings)
  6. often talks excessively
  7. often blurts out an answer before a question has been completed (i.e completes peoples sentences, cannot wait for turn in coversation)
  8. often has difficulty waiting their turn
  9. often interrupts or intrudes on others (i.e butts into conversations or games, may start using other peoples things without permission)
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7
Q

what is criterion B for ADHD

A

several inattentive or hyperactive/impulsive symptoms were present prior to age 12 years

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8
Q

what is criterion C for ADHD

A

several inattentive or hyperactive/impulsive symptoms are present in two or more settings (i.e at home, school, work, with friends, other activities)

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9
Q

what is criterion D for ADHD

A

there is clear evidence that the symptoms interfere with, or reduce the quality of, social, academic, or occupational functioning

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10
Q

what is criterion E for ADHD

A

the symptoms do not occur exclusively during the course of schizophrenia or another psychotic disorder and are not better explained by another mental disorder

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11
Q

what are the 3 diagnostic DSM specifiers for ADHD

A
  1. combined presentation–>
    if both criterion A1 (inattention) and criterion A2 (hyperactivity) are met for the last 6 months
  2. predominantly inattentive presentation–> if criterion A1 is met but not A2 for the last 6 months
  3. predominantly hyperactive/impulsive presentation –> if criterion A2 is met but not A1 for the last 6 months

*when full criteria were previously met, but fewer than the full criteria have been met for the last 6 months and the symptoms still results in impairment, can specify IN PARTIAL REMISSION

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12
Q

how do you grade severity for ADHD

A

mild–> moderate–> severe

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13
Q

define mild ADHD

A

few, if any, symptoms in excess of those required to make the diagnosis are present, and symptoms result in no more than minor impairments in social or occupational functioning

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14
Q

define moderate ADHD

A

symptoms or functional impairment between mild and severe are present

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15
Q

define severe ADHD

A

many symptoms in excess of those required to make the diagnosis, or several symptoms that are particularly severe are present, or the symptoms result in marked impairment in functioning

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16
Q

what is the essential feature of ADHD

A

persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development

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17
Q

how does inattention manifest behaviourally in ADHD

A

wandering off task, lacking persistence, having difficulty sustaining focus, being disorganized

not due to defiance or lack of comprehension

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18
Q

what does hyperactivity refer to in ADHD

A

excessive motor activity (such as a child running about) when it is not appropriate, or excessive fidgeting, tapping or talkativeness

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19
Q

how might hyperactivity manifest in adults with ADHD

A

extreme restlessness or wearing others our with their activity

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20
Q

what does impulsivity refer to in ADHD

A

hasty actions that occur in the moment without forethought and that have high potential for harm to the individual (ie darting into the street without looking)

impulsivity may reflect a desire for IMMEDIATE REWARDS or an inability to DELAY GRATIFICATION

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21
Q

how might impulsive behaviours manifest in ADHD

A

social intrusiveness and/or making important decisions without consideration of long term consequences

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22
Q

how do you make sure symptoms of ADHD occur across settings

A

consult informants who have seen the individual in those settings

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23
Q

how do symptoms vary within a setting

A

vary depending on context within a given setting–> ie signs of the disorder may be minimal or absent when the individual is receiving frequent rewards for appropriate behaviour, is under close supervision, is in a novel setting, is engaged in especially interesting activities, has consistent external stimulation or is interacting in one on one situations

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24
Q

list some associated features that may support diagnosis of ADHD

A
  1. though not specific to ADHD, mild delays in language, motor or social development often co occur with adhd
  2. low frustration tolerance
  3. irritability
  4. mood lability
  5. academic or work performance often impaired even in absence of specific learning disorder
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25
Q

how does ADHD impact risk of suicide

A

by early adulthood, ADHD is associated with an INCREASED RISK of suicide attempt

*primarily when comorbid with mood, conduct or substance use disorders

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26
Q

is there any biological marker that is diagnostic for adhd?

A

no

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27
Q

what findings might there be on EEG that would be consistent with ADHD

A

increased slow wave EEGs

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28
Q

what findings might there be on MRI that would be consistent with ADHD

A

reduced total brain volume

+

delay in posterior to anterior cortical maturation

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29
Q

what is the prevalence of ADHD

A

5% of children and 2.5% of adults across most cultures

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30
Q

after what age do symptoms of hyperactivity become more clearly distinguishable from normative behaviours

A

after age 4

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31
Q

when is ADHD most often identified

A

elementary school years

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32
Q

what is the natural course of ADHD

A

most often IDed in elementary school–> most people have relatively STABLE course through early adolescence, though some have worsening course with development of ANTISOCIAL behaviours –> in most people, symptoms of hyperactivity become less obvious in adolescence and adulthood but difficulties with RESTLESSNESS, INATTENTION, poor PLANNING and IMPULSIVITY persist

a substantial proportion of kids with ADHD remain relatively impaired into adulthood

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33
Q

what is the main manifestation of ADHD in preschool

A

hyperactivity

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34
Q

when does inattention become more prominent in ADHD

A

elementary school

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35
Q

ADHD is associated with which temperamental factors

A

ADHD is associated with: 1. reduced behavioural inhibition, effortful control, or constraint
2. negative emotionality
3. elevated novelty seeking

*may predispose to ADHD but not specific to the disorder

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36
Q

list environmental risks for ADHD

A
  1. very LOW BIRTH WEIGHT (less than 1500 grams)–> 2-3x risk for ADHD
    (but most kids with low birth weight do not develop adhd)
  2. correlated with SMOKING during pregnancy
  3. minority of cases may be related to reactions to aspect of diet
  4. may be history of childhood abuse, neglect, multiple foster placements
  5. neurotoxin exposure (i.e lead)
  6. infections (i.e encephalitis)
  7. alcohol exposure in utero
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37
Q

what is the genetic risk associated wtih ADHD

A

risk of ADHD elevated in first degree relatives–> heritability is substantial

specific genes HAVE been correlated to adhd, but they are neither necessary nor causal

38
Q

what are some physiologic conditions that may be considered to have influence on adhd symptosm

A

visual and hearing deficits

metabolic abnormalities

sleep disorders

nutritional deficiencies

epilepsy

39
Q

is adhd associated with any particular physical features

A

no–> however, rates of minor physical anomalies (hypertelorism, highly arched palate, low set ears) may be relatively elevated

subtle motor delays and other soft neuro signs may occur

40
Q

do family interaction patterns in early childhood cause adhd

A

no, but may influence the course if the condition

41
Q

how does diagnosis of adhd differ between males and females

A

adhd more frequently diagnosed in males than females in the general population –>

RATIO 2:1

*females more likely to present with primarily inattentive

42
Q

describe the functional impact of ADHD

A

adhd is associated with:

  1. reduced school performance and academic achievement
  2. social rejection
  3. poorer occupational performance, attainment, attendance and higher probability of unemployment in adults
  4. elevated interpersonal conflict
  5. kids wtih ADHD are significantly more likely to develop CONDUCT DISORDER in adolescence and ANTISOCIAL personality disorder in adulthood (thus increased likelihood of substance use and incarceration)
  6. more likely to be injured
  7. traffic accidents and violations are more common in drivers with ADHD
  8. may be elevated likelihood of obesity
43
Q

how does ADHD impact risk of substance use disorders

A

elevated risk of SUDs, especially when conduct disorder or antisocial personality traits develop

44
Q

how might ADHD affect interpersonal functioning

A

symptoms may be misinterpreted by others as laziness, irresponsibility or failure to cooperate

family relationships may have discord and negative interactions

peer relationships may have peer rejection, neglect, teasing

45
Q

which negative functional outcomes of adhd tend to be more associated with inattention symptoms? hyperactive symptoms?

A

inattentive–> academic deficits, school related problems, peer neglect

hyperactive–> peer rejection, accidental injury

46
Q

ddx for ADHD

A
  1. ODD
  2. intermittent explosive disorder
  3. other neurodevelopmental disorders
  4. specific learning disorder
  5. intellectual disability
  6. ASD
  7. reactive attachment disorder
  8. anxiety disorders
  9. depressive disorders
  10. bipolar disorder
  11. disruptive mood dysregulation disorder
  12. substance use disorders
  13. personality disorders
  14. psychotic disorders
  15. medication induced symptoms
  16. neurocognitive disorders
47
Q

what distinguishes ODD from ADHD

A

ODD–> resist work or school tasks because they resist CONFORMING to others demands

ADHD–> aversion to school or mentally demanding tasks due to difficulty in sustaining mental effort, forgetting instructions, impulsivity

*complicated by fact that some kids with ADHD may develop secondary oppositional attitudes towards such tasks

48
Q

what traits do ADHD and intermittent explosive disorder share

A

high levels of impulsive behaviour

49
Q

what distinguishes intermittent explosive disorder from ADHD

A

those with intermittent explosive disorder show serious aggression towards others, which is not characteristic of ADHD (and in intermittent explosive disorder they do not have difficulty sustaining attention)

intermittent explosive disorder is also RARE in childhood

50
Q

how to distinguish between stereotypic movement disorder and ADHD

A

in stereotypic movement disorder, the motoric behaviour is generally FIXED and REPETITIVE whereas fidgetiness and restlessness in ADHD are typically generalized and not characterized by repetitive stereotypic movements

51
Q

why might children with specific learning disorder appear inattentive (in the absence of ADHD)

A

due to frustration, lack of interest or limited ability (but this inattention is not impairing outside of academic work, as it is in ADHD)

52
Q

which is more likely in a preadolescent who displays severe irritability and anger, bipolar disorder or ADHD?

A

ADHD–> bipolar disorder is rare among preadolescents, even when severe irritability and anger are prominent, whereas ADHD is common among children and teens who display excessive anger and irritability

53
Q

what features do personality disorders like borderline PD share with ADHD

A

disorganization, social intrusiveness, emotional dysregulation and cognitive dysregulation

54
Q

what are some medications that can result in symptoms mimicking ADHD

A

bronchodilators
isoniazid
neuroleptics–> akathisia
thyroid meds

(can lead to symptoms of inattention, hyperactivity or impulsivity)

55
Q

what % of kids with combined type ADHD also meet criteria for ODD? what about those with inattentive type ADHD?

A

50% of kids with combined type also have ODD

25% of kids with inattentive type also have ODD

56
Q

what % of kids with combined type ADHD also meet criteria for conduct disorder?

A

25% (depends on age and setting)

57
Q

what is the relationship between occurrence of disruptive mood dysregulation disorder and ADHD?

A

MOST kids with disruptive mood dysregulation disorder have symptoms that also meet criteria for ADHD

a lesser percent of kids with ADHD have symptoms that meet criteria for disruptive mood dysregulation disorder

58
Q

what are some common comorbidities that occur with ADHD

A

ODD

conduct disorder

disruptive mood dysregulation disorder

specific learning disorder

anxiety and depression (minority of people with ADHD, but rate is still higher than in the general population)

intermittent explosive disorder (occurs in minority of adults with ADHD, but higher rate than population levels)

substance use disorders (“)

antisocial and other PDs (in adults)

OCD, tic disorders, autism

59
Q

how do you distinguish between ODD and ADHD

A

those with ODD may resist work or school tasks that require self application because they RESIST CONFORMING to others demands –> behaviour characterized by NEGATIVITY, HOSTILITY, DEFIANCE

this must be distinguished from aversion to school or mentally demanding tasks due to difficulty sustaining mental effort, forgetting instructions, and impulsivity in those with ADHD

*those with ADHD may develop secondary oppositional attitudes toward such tasks and devalue their importance

60
Q

what do ADHD and intermittent explosive disorder have in common

A

high levels of impulsive behaviour

61
Q

how do you distinguish between intermittent explosive disorder and ADHD

A

those with IED show serious aggression towards others, which is not characteristic of ADHD

those with IED do not have problems sustaining attention

IED is rare in childhood

62
Q

what do those with ADHD and ASD have in common

A

both exhibit inattention, social dysfunction, and difficult to manage behaviour

63
Q

how do you distinguish between ADHD and ASD

A

ADHD–> social dysfunction and peer rejection

ASD–> social disengagement, isolation, indifference to facial and tonal communication cues

64
Q

what medication may mimic symptoms of ADHD

A

(i.e symptoms of inattention, hyperactivity, impulsivity)

–bronchodilators
–isoniazid
–neuroleptics (resulting in akathesia)
–thyroid replacement meds

65
Q

how often do ADHD and ODD co-occur

A

in approx 50% of children with the combined ADHD type, and in about 25% with the predominantly inattentive type

66
Q

how often do conduct disorders co occur with ADHD

A

25% of those with combined type (depending on age and setting)

67
Q

what is the relationship between disruptive mood regulation disorder and ADHD

A

MOST kids with DMDD also meet criteria for ADHD

a LESSER % of those with ADHD have symptoms that meet criteria for DMDD

68
Q

how often do anxiety and depressive disorders co occur with ADHD

A

more than in the general population but still a minority of those with ADHD

69
Q

are substance use disorder common among those with ADHD

A

occurs in minority of those with ADHD but still more than the general population

70
Q

list common comorbidities with ADHD

A

ODD*

Conduct disorder*

DMDD*

specific learning disorder*

anxiety and depressive disorders

intermittent explosive disorder (adults)

substance use disorders

antisocial/other PDs

OCD

tic disorder
autism

*=fairly common co occurence

71
Q

by how much does having ADHD increase risk for accidental injuries

A

by 2x

72
Q

how does ADHD affect substance use

A

higher risk of earlier substance use

greater difficulty with substance use

73
Q

what is the heritability of ADHD

A

about 76%

parents with ADHD have a more than 50% chance of having a child with ADHD

close to 25% of kids with ADHD have a parent who meet formal criteria

first degree relatives of diagnosed ADHD people have a 30-40% chance

74
Q

list genes implicated in ADHD

A

DAT1

DRD4

DRD5

DBH

5-HTT

HTR1B

SNAP-25

75
Q

list non-genetic factors that can increase risk of ADHD

A

perinatal stress

low birth weight

TBI

maternal smoking during pregnancy

severe early deprivation

frequent digital media use

76
Q

what is a mnemonic to remember the inattentive symptoms of ADHD

A

CALL FOR FRED

Careless mistakes
Attention Difficulty
Listening problems
Loses things

Fails to finish what they start
Organizational skills lacking
Reluctance to do tasks that require sustained mental effort

Forgetful in Routine activites
Easily Distracted

77
Q

what is a mnemonic to remember the hyperactivity-impulsivity symptoms of ADHD

A

RUNS FASTT

Runs or is restless
Unable to wait turn
Not able to play quietly
Slow? Oh no! Hes on the go!

Fidgets with hands or feet
Answers are blurted out
Staying seated is difficult
Talks excessively
Tends to interrupt

78
Q

in a classroom, which child is most likely to get an ADHD diagnosis

A

the child with the latest birthdate in the class (i.e august bday in a class with sept 1 cutoff)

likely due to teacher perceiving immature but age appropraite behaviours as reflecting ADHD in this really much younger child

79
Q

name some rating scales that can help assess ADHD

A

SNAP-IV 26

Adult ADHD self report scale

Conners rating scale revised

80
Q

what brain changes might you see in someone with ADHD

A

smaller bilateral amygdala, accumbens and hippocampus

*under debate

81
Q

what sleep disorder should you consider on ddx for ADHD

A

OSA

also insomnia or central sleep apnea

82
Q

what is a principle upon which to organize approach to treatment of ADHD

A
  1. psychoeducation and support for ALL
  2. behavioural treatments for MOST
  3. medications for SOME
83
Q

what are two medications with psychomotor activation that may mimic ADHD

A

decongestants

beta agonists (puffers)

84
Q

what are some medical conditions that should be considered when evaluating for ADHD

A

neurofibromatosis

phenylketonuria

fragile X

lead poisoning

anemia

hypoglycemia

thyroid disease

seizure disorders

TBI

sleep disorders

85
Q

what should be conveyed in psychoeducation around ADHD

A

Explaining the rationale for the diagnosis, referencing examples of symptoms and impairment given by the parents and child/adolescent

Explaining that although ADHD has a genetic component, environmental interventions can still be immensely helpful

Reviewing the natural course and prognosis of ADHD and discuss comorbid conditions
Discussing available treatment options (both pharmacological and non-pharmacological)

Conveying a message of hope and optimism, telling the patient and family that ADHD tends to improve over time and is among the most treatable of psychiatric disorders

86
Q

what is the first line treatment for ADHD in preschoolers

A

parent management training/psychosocial treatment

87
Q

list types of behavioural interventions that have been investigated in ADHD

A

parent management training modules

social skills training

CBT

mindfulness training

88
Q

what is the average response rate to medications in ADHD

A

about 70%

about 90% will respond to stimulants in the short term

89
Q

what % of people will respond equally to methylphenidate and amphetamine stimulants

A

40%

another 20% each will respond only to one class of medications

(on population level, no difference in efficacy or tolerability between these classes, but individuals may have differing responses)

90
Q

what are 3 principles of ADHD pharmacotherapy

A
  1. long acting stimulants preferred as first line (should do adequate trial of both classes of long acting stimulant before going to second line)
  2. short and intermediate acting stimulants and non stimulants are second line
  3. third line agents = buproprion, clonidine, modafinil, AAPs may be adjunct with 1st or 2nd line agents
91
Q

is there difference between picking clonidine vs guanfacine as adjunct

A

not in terms of efficacy

92
Q

how might second line stimulants be used

A

as primary agent

as PRN

to augment long acting formulations early or late in the day or early in evening