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Oral Sciences > Reading 10/3 > Flashcards

Reading 10/3 Flashcards

1
Q

The serum component of OF enter via:

A

damaged oral mucosa, periodontium (crevicular fluid)

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2
Q

Sublingual gland secretions:

A

rich in mucin, little amylase

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3
Q

Parotid gland secretions:

A

Main source salivary amylase and basic proline-rich proteins, no mucin

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4
Q

Can change throughout the day:

A

amt of fluid secreted, protein composition

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5
Q

Portion of saliva that offers the greatest amount of protection:

A

protein

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6
Q

Protection provided by protein portion;

A

wear, attrition, abrasion, erosion

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7
Q

Main buffering component of saliva:

A

bicarbonate

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8
Q

Function of pellicle:

A

prevention of acid erosion, lubricating property reduces mechanical wear

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9
Q

2 reasons pts w Sjorgen’s Syndrome are prone to caries, wear, and erosion:

A

loss of protection of saliva, sweet and acidic foods to relieve dry mouth

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10
Q

Functions of mucins:

A

anti- viral, bacterial, fungal, bolus formation, inhibition of demin, lubrication, viscoelasticity, prevention of inflammation and mech wear

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11
Q

Functions of histatin:

A

anti- bacterial, fungal

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12
Q

Functions of Ig’s:

A

Anti- viral, fungal

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13
Q

Function of zinc:

A

taste

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14
Q

Function of Cystatins:

A

anti- viral, bacterial

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15
Q

Function of bicarbonate phosphate proteins:

A

buffering

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16
Q

Function of proline-rich glycoprotein:

A

lubrication, viscoelasticity, remin

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17
Q

Salivary component that provide ONLY antibacterial affect:

A

(VALLL) lysozyme, lactoferrin, lactoperoxidase, agglutinin, VEGh

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18
Q

Function of Ca phosphate, proline-rich glycoproteins and statherin:

A

remin

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19
Q

Only salivary component w anti bacterial/viral/fungal properties:

A

mucins, most important component of saliva

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20
Q

Function of amylase:

A

starch to soluble maltose, dextrin, digestion initiation

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21
Q

Initiates fat digestion:

A

salivary lipase

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22
Q

P gland secretions upon mechanical stimulation:

A

watery fluid, rich in bicarbonate

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23
Q

Main protein components of P gland secretion:

A

60% proline-rich proteins, 20% amylase, 7% phosphoproteins (statherin)

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24
Q

Major constituents of pellicle:

A

(PPP) phosphoproteins and proline-rich proteins

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25
Q

Function of both phosphoproteins and proline-rich proteins:

A

saliva supersaturated w Ca2+

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26
Q

Functions of P gland saliva:

A

rinsing, neutralization, pellicle formation

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27
Q

TF? Subl and subm gs’ are active at rest.

A

T

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28
Q

main source of salivary mucins (MUC5B and MUC7):

A

Subs, and minors

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29
Q

List salivary mucins:

A

MUC5B and MUC7

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30
Q

Main fxn of MUC5B:

A

protect (chem, phy, microbial) hard and soft tissues of mouth, large gel-forming molecule, backbone of slime layers of oc, diffusion barrier to noxious agents, protons, reduce wear due to friction

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31
Q

Can saliva substitutes completely replace the role of MUC5B?

A

no

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32
Q

saliva substitutes:

A

carboxymethylcellulose, mucins from animals, organic gums (xanthan)

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33
Q

Binding capability of MUC5B:

A

limited # of bacteria, esp. H. pylori, H. parainfluenza, Candida albicans, HIV-12

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34
Q

MUC7:

A

low-molecular weight, broad spectrum bacteria binding, helps in clearance of oc of bacteria

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35
Q

How MUC7 interacts w HIV-1:

A

encapsulate, inactivate, support adhesion of Strep mutans, enhance colonization - Then ppl w HIV are more prone to caries?

36
Q

Likely infection w hyposalivation:

A

palatal candidiasis

37
Q

Xerostomia, hyposalivation, subjective or objective?

A

subjective, objective

38
Q

Are xerostomia and hyposalivation always congruent?

A

no

39
Q

Effects of hyposalivation:

A

dry tissues, fissures in tongue

40
Q

Main cause of hyposalivation;

A

medications: antipsychotics, sedatives, B-blocker, antihypertensives, tranquilizers, all block neurotransmission to sgs

41
Q

How to overcome blockage of sgs caused by meds?

A

mech, gustatory stimulation

42
Q

TF? Mech or gustatory stimulation can be used to increase salivary secretions at any stage of Sjorgen’s syndrome.

A

F. gradually declines with d. progression

43
Q

Radiation of these structures often leads to complete loss of salivary g function:

A

tumor in oral cavity or oropharynx, stimulation not an option, palliative tx only, artificial saliva, hydrating gels

44
Q

TF? Hyposalivation increases w age.

A

T, but not to an appreciable extent, enough to function

45
Q

% of pop w hyposalivation:

A

6-10%

46
Q

% of ppl over 50 with hyposalivation:

A

25%

47
Q

% of ppl over 80 with hyposalivation:

A

40%

48
Q

Do neuropharmaceuticals usually have an absolute specificity for their target organ?

A

No

49
Q

Antihypertensives also block:

A

neuroreceps of sgs

50
Q

Xerostomis is likely to occur when a pt is taking _#__ mds:

A

5+

51
Q

Change in sgs w age:

A

amt of secretory tissue decreased, but does not lead to an appreciable loss of secretion

52
Q

Wo antimicrobial proteins and peptides this shift happens:

A

toward Gram -, more virulent, i.e., C. albicans

53
Q

C. albican infection can occur after how many days of hyposalivation?

A

w/in a few

54
Q

What helps the mucosal tissue to protect the underlying epi against mech, chem, and microbial injury?

A

mucous slimy layer

55
Q

Decrease in mucin leads to:

A

susceptibility to infections, inflammation, and tissue damage

56
Q

Mineral of dental enamel:

A

calcium hydroxyapetite

57
Q

Pellicle has:

A

calcium-binding phosphoproteins, salivary proteins, mucins in older pellicle

58
Q

Mucins protect against:

A

acid

59
Q

Fxns of salivary proteins:

A

protect dental surface, inc local conc of Ca and P on mineral surface, remin

60
Q

Enamel and dentin material is what type of salt?

A

basic

61
Q

hydroxyapetite at neutral pH, soluble or insoluble in saliva?

A

insoluble

62
Q

pH of saliva under normal condition:

A

6.8

63
Q

pH of intrinsically low saliva:

A

6.2, prone to caries and erosion

64
Q

pH rises to this after bicarbonate secretion:

A

7.4

65
Q

Name an agglutinating factor:

A

sIgA

66
Q

Main secretory protein of adaptive immunity in saliva:

A

sIgA

67
Q

Function of bacteria-agglutinating factor:

A

antimicrobial

68
Q

sIgA binds:

A

selectively to antigens (microbes, viruses), prevents attachment to dental surfaces

69
Q

How can anitgen binding be prevented?

A

agglutination of microbes, hampering motility by interfering with flagellum, blocking interactions bw recep and ligand on epi cell

70
Q

Cells of these tissue are responsible for local IgA production:

A

MALT (tonsils, Peyer’s patches, etc.)

71
Q

What happens after IgA is activated?

A

migrate to exocrine glands, stay in interstitium as IgA-producing palsma cells, make polymeric form of IgA, get taken up by glandular acinar cells, then secreted in saliva as sIgA

72
Q

Other main agglutinating factors besides sIgA:

A

low-MW mucin MUC7 (serous cells, subl and subm), salivary agglutinin gp340

73
Q

Cells that secrete MUC7:

A

serous

74
Q

Glands that make MUC7:

A

subl and subm

75
Q

Glands that secrete gp340:

A

parotid and subm

76
Q

What gland secretes both MUC7 and gp340?

A

subm

77
Q

Function of sIgA, gp340, and MUC7:

A

interfere in soluble phase w binding of microbes to oral surfaces

78
Q

MUC7 and gp340, broad specificity or not?

A

yes, broad

79
Q

Proteins that inactivate or kill bacteria:

A

lysozyme (gram-positive bacterias), lactoperoxidase, lactoferrin, and antimicrobial peptides (histatins, cathelicidin LL-37)

80
Q

Lysozyme acts on:

A

gram-positive baceria

81
Q

Ex’s of antimicrobial peptides:

A

salivary glycoproteins, histatins and cathelicidin LL-37

82
Q

rheology:

A

branch of physics that deals w deformation and flow of matter

83
Q

Most important constituent of saliva:

A

mucins (viscoelasticity, resistance to proteolytic degradation)

84
Q

TF? Saliva of healthy elderly people is sufficient in volume.

A

T

85
Q

Subl g is the largest supplier of:

A

lipase and proline-rich glycoproteins

Oral Sciences (16 decks)

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