Reabsorbtion And Secretion Flashcards
Summary of last lecture quiz:
What are 4 barriers to filtration of proteins in the kidney?
Define Proteinuria
What are the 3 common diseases characterized by Proteinuria.
Supposing MAP increases from 100 mm Hg
to 110 mm Hg…what happens to GFR? Why? (Go through pathway)
Stays the same!
Define the 5 steps and 3 effects that happen for Tubuloglomerular feedback response to increased MAP. (What structure is vital for it? (What are the parts of the structure).
Bonus: also has a second function, what is it?
Supposing MAP decreases from 110 mm Hg
to 100 mm Hg…what happens to GFR?
What happens to the afferent arteriole?
In a response to a hemorrhage(blood loss), there are 4 cascading responses given by the Sympathetic nervous system that inevitably change the GFR, what are they?
GFR is also affected by two other chemicals, what are they?
This is NOT auto regulation anymore.
E.
What is the major determinant of GFR?
Excluding autoregulation, what other GFR regulation pathway favors effecting the Afferent arteriole? And which one favors the efferent arteriole?
The hydrostatic pressure in these glomerular capillaries.
What do ACE inhibitors do?
How much Glucose, Sodium, and water is reabsorbed? All 3 of these are mass filtered out at the mass filtration.
What are the 4 general principles of Tubular reabsorption?
What is the general pathway for organic molecule reabsorption? Use glucose as the example.
What drugs inhibit this and why?
Hyperglycemia in diabetes mellitus can lead to _________ of transporters involved in glucose reabsorption.
What does this lead to? (Looking for mechanism and the medical term).
Where does organic molecule reabsorption (and secretion) occur?
Lots of membrane folds, microvili on apical side and lots of folds on basolateral side too. Increasing surface area for expression of transport proteins.
Also lots of mitochondria to help with the active transport.
What are the 4 places Sodium gets absorbed along the nephron? What %?
What drugs effect what part of this pathway? What do they treat?
Sodium is reabsorbed in a lot of places.
All treatments are for too much volume!
Explain what Thiazide drugs inhibit and where this happens?
What do loop diuretics inhibit and where?
How does the loop of Henle work in the medulla to provide the driving force for water reabsorption? (Broad overview)
What transporters are involved in organic molecule secretion? What are their mechanisms?
Transporters involved in organic molecule secretion have broad specificity, what does this mean both by detention and by the outcome that this leads to when treating disease.
The “key” to the “lock” is very broad like it being an anion, etc.
Renal handling:
Define reabsorption.
Define secretion.
Give the full equation to calculate amount of solute excreted.
B.
Summary slide:
What is vasopressin, what does it do?
