Antibodies And T Cell Receptors Flashcards
Explain how phagocytes also work as antigen presenting cells.
What do B and T lymphocytes do respectively?
What are 3 secondary lymphoid tissues?
What are lymph nodes?
What is lymph?
Kind of like extracellular fluid.
lymph forms because hydrostatic pressure in the capillary is slightly higher than colloid osmotic pressure
Lymphatic capillaries are leaky, explain what that means.
Define what makes something a primary vs secondary lymph node.
Name 2 primary lymph nodes and 3 secondary lymph nodes.
Define what a B-Cell receptor is.
an antibody with a transmembrane domain expressed on the surface of a B cell.
Define what a T-Cell receptor is.
Define what MHC is.
Draw out an antibody. What’s the variable region, Fc region, light chain, and heavy chain.
Name the 4 classes on antibodies. What they target, and distinct shapes if they gave them.
The B cell receptor is the membrane-bound form of the antibody found on what?
Naive B cells.
T cell receptors:
Where are the located?
How many binding sites?
What do they bind to?
What’s the requirement to bind?
What are T cells responsible for?
T-cell receptors (TCR) bind antigens displayed on MHC molecules. Explain how each MHC type elicits a different response.
What are MHC molecules?
What are the two classes?
Where are the each found respectively?
Explain the 3 different type of T cells, how they are activated and what they do when activated.
Helper T cells:
What do they bind to?
What do they do when bound?
Extra: what VERY known disease(STI) kills this type of cell?
Cytokines from Th cells:
What do they do? (3)
Cytotoxic T cells:
What do they bind to?
What do they do?
A way to classify T cells is one binds to a extracellular antigen, and the other binds to an intracellular antigen. Which one binds which?
What is the main thing responsible for the diversity of our antibodies?
Define self-tolerance.
self-tolerance: lack of immune response to self antigens
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