RBC and Kidney

Question 1

Fatigue and jaundice due to hemolytic anemia (elevated bilirubin & LDH, low haptoglobin, hemoglobinuria), thrombosis at atypical sites (hepatic, portal, cerebral veins), pancytopenia, iron deposition in the kidney (hemosiderosis)

Answer 1

Paroxysmal nocturnal hemoglobinuria

Question 2

Cause of paroxysmal nocturnal hemoglobinuria

Answer 2

complement-mediated hemolysis due mutated glycosylphosphatidylinositol anchor protein that anchors CD55 and CD59 to the RBC cell surface that inactivate complement