Paraneoplastic Syndromes Flashcards
Cushing syndrome
Small cell lung cancer, pancreatic cancer
Etiology of paraneoplastic syndromes in small cell lung cancer (4)
- Ectopic production of ACTH/CRH
- Ectopic vasopressin production
- Anti-Yo, Anti-P/Q, and Anti-Hu antibodies
- Voltage-gated calcium channel antibodies
Etiology of paraneoplastic syndrome in pancreatic cancer
Ectopic production of ACTH/CRH
SIADH
Small cell lung cancer
Subacute cerebellar degeneration
Small cell lung cancer; Breast, ovarian, and uterine cancers
Etiology of paraneoplastic syndrome in Breast, ovarian, and uterine cancers
Anti-Yo, Anti-P/Q, and Anti-Hu antibodies
Lambert-Eaton myasthenic syndrome
Small cell lung cancer
Myasthenia gravis
Thymoma
Etiology of paraneoplastic syndrome in thymoma
Acetylcholine receptor antibodies
Hypercalcemia
Squamous cell lung cancer
Etiology of paraneoplastic syndrome in Squamous cell lung cancer
Ectopic production of parathyroid hormone-related protein
Dermatomyositis/Polymyositis
variable, carcinoma (e.g. gastric carcinoma)
Etiology of paraneoplastic syndrome in Dermatomyosistis/polymyositis
Autoimmune, sometimes ANA and anti-Jo-1 antibodies
Erythrocytosis
Renal cell cancer
Etiology of paraneoplastic syndrome in Renal cell cancer
Ectopic erythropoietin production