Biochem

Question 1

Pyruvate dehydrogenase deficiency clinical findings

Answer 1

Neurological defects, Pyruvate gets shunted to lactate and alanine –> increased in serum

Question 2

Pyruvate dehydrogenase deficiency treatment

Answer 2

High intake of ketogenic nutrients i.e. high fat content or lysine and leucine (the only pure ketogenic amino acids)