Rare conditions and pearls

Question 1

what is Gauchers Disease:

Answer 1

Lysosomal Storage disease, defect in acid beta glucosidase enzyme. features are spleno and hepatomegally, low plt, anemia, bone pain, flask deformity 1:40k general pop, 1:850 ashkenazi Jews

Question 2

Thorough way to develop a differential diagnosis on difficult cases

Answer 2

Vitamins ABCDEK
Vascular, infectious, trauma (pressure, obstruction), auto immune/ Allergy, metabolic/Medicines, iatrogenic/ Idiopathic, neoplastic, social (abuse, neglect), alcohol/age, behavioral or psychosomatic, congenital, degenerative, or drugs, environmental, endocrine, or exocrine, karyotype/genetics

Question 3

Criteria you can use to show probability of DVT

Answer 3

Wells criteria

Question 4

Thromboangitis Obliterans

Answer 4

Buerger’s Disease

Question 5

Adhesive Arachnoiditis

Question 6

When should you not use D-Dimer

Answer 6

If risks are really high don’t believe a normal D-Dimer get u/s or CTA

Question 7

High risk of Upper GI bleed with this lab ratio

Answer 7

BUN/CR ratio >36 high chance of upper GI bleeding