random stuff Flashcards
macrobid avoid in
crcl less than 60
biaxin
clarithromycin
stoke tx
iv alteplase (tpa, activase)
temazepam
restoril (only for insomnia
benzos pregnancy category
D
benzo antidote
flumazenil
paroxetine paxil pregnancy category
D
depression drugs that are cypd 2d6 inhibitors
paroxitine (paxil), fluoxetine(prozac), sertraline(zoloft, duloxetine (cymbalta), bupropion (wellbutrin) avoid with tamoxifen! may decrease effects
citalopram celexa max dose because of QT
prolongation
if greater than 60 max dose is ?
40mg/day
20 mg/day
ssri w long t1/2, no tapering off
fluoxetine (prozac)
fluvoxamine brand
luvox only for OCD
venlafaxine snri brand
effexor
desvenlafaxine snri brand
pristiq
milnacripran snri brand
savella
blood pressure difference between snri and ssri
snri hypertension
ssri hypotension
bupropion causes
seizures
mirtazapine main points
weight gain
sedation
qt prolongation
ODT!
bedwetting
imipramine, or desmopressin
robitussin DM or delsym increses
serotonin
MAOIs
isocarboxazid (marplan)
phenelzine (nardil)
tranylcypromine (parnate)
selgeline (emsam)
gold standard bipolar med
lithium if contraindicated
depakote (divalproex)
lithium or divaloproex sodium combined with an antipsychotic is more effective than
monotherapy
vaLProic acid SE
liver failure, pancreatitis
Lamotrigine SE
RASH
carbamazepime SE
looks like TCAs so anticholinergic effects
also HLAb1502 test
aplastic anemia
agranulocytosis
lithium level
0.6-1
lithium with or without food
with food!
lithium pregnancy category
D
meds that increase lithium
nsaids, thiazides, aces
lithium with SSRIS
may cause serotonin syndrome
xanathine oxidase inhibitors
allopurinol (zyloprim, aloprim)
febuxostat (uloric)
no nsaids in
renal and hypertension
allopurinol hlab
5801
allopurinol main SE
rash
allopurinol DI
azathioprine
6mp
warfarin
thiazide + ace
carbamezapime hlab
1502
abacavir hlab
5701
dopamine agonists for parkinsons also approved for RLS
pramipexole (mirapex)
ropinorole (requip xl)
rotigotine (neupro) patch
apomorphine
ceftriaxone do you dose adjust in renal?
NO
carbapenems number 1 side effect
seizures
1st line for chronic angina
BBs
1st line for vasospastic angina (prinzmetals)
ccb
close angle glaucoma (er emergency) treatment
acetazolamide (diamox) iv -sulfa allergy
main two side effects with PTU and methimazole
agranulocytosis and hepatotoxicity
thyroid dosing in age 60 or less no conditions
1.6mcg/kg/day using IBW
thyroid dosing in greater than 60 no conditions
25 to 50 mcg once daily
thyroid dosing in patients with CAD
12.5 to 50 mcg once daily
BB antidote
glucagon
benadryl antidote
atropine
isoniazid antidote
pyridoxine B6
mtx antidote
leucovorin
ttp
brillinta (ticragelor)
niaspan
extended release niacin
less flushing than normal niacin
can cause rhabdo
steroid things to review in a chart
A1C
WBC
Weight
Blood Pressure
Epclusa is used to treat what and what are the compenets
hep C and
med that can cause positive coombs test
macrobid
a pharmacist cant make capsules from what
creams
citalopram increases bleeding risk with
warfarin
integrillin MOA
glycoprotein 11b,111a receptor antagonist
levemir and toujeo pen
42 days
novolog pen
28 days
tresiba pen
56 days
lantus pen
28 days
tradjenta (linagliptin) can cause
pancreatitis
treat PAH and has a boxed warning for embryo fetal toxicity
ambristentan
atripla components
efavirenz, emtriciabine, tenofivir
atripla at ___ on an ___ ____
at bedtime on an empty stomach
causes of CAP
pneumococcus pseudomas mycoplasma pneumoniae moraxella catarhalhalis mrsa legionella h flu
bisphosphonates not used if crcl less than
35
pulmonary capillary wedge pressure reduced most by
lasix (loop)
edoxaban
savyasa - factor xa inhibitor
inr >10 with no bleeding what to do
2.5- 5 mg po vitamin k
plus hold warfarin
ssris and snris can cause hypo
hyponatremia
oral anticoags that do not require bridging
apixaban and rivaroxaban
metformin does not increase
insulin production
for type 1 and type 2 DM
symlin
aspergillosis
vfend- voriconazole
bacterial vaginosis - fishy smell
metronidazole
oral thrush
nystatin swish and swallow
herpes
valacyclovir (valtrex)BID
CLASS II cabinent is for
high risk hazardous drugs
how long is hep c treatment
12 weeks
cap outpatient healthy no combor.
amoxicillin high dose or doxycycline
cap outpatient with comorb.
beta lactam:augmentin, cefuroxime, cefopoxidime
+macrolide or doxycyline
or monotherapy with a respiratory FQ
non severe in patient cap without risk for MRSA or pseudomonas
IV beta lactam (unasyn, cefotaxime, ceftaroline, caftriaxone)
+macrolide
Monotherapy: respiratory FQ
inpatient cap severe without risk for MRSA or pseudomonas
blactam+ macrolide or blactam +FQ
trichomonas
a single 2g dose, or 500mg bid X 7 days of metronidazole (flagyl) or tinidazole (tindamax)
genital herpes
valacyclovir, acyclovir, famicyclovir
Chlamydia
doxycycline 100 mg BIDx7days
or
Azithromycin 1 g single dose (okay if pregnant)
gonorhhea
ceftriaxone 500 mg single IM inj
if chlamydia is not excluded add doxy 100 mg bid x 7 days
syphillis
benzathine PCN G IM (bicillin LA not CR)
2.4 MU IM x1
MI gets antiplatelets not coags
dual therapy asa and plavix
calcium carbonate
40%
calcium citrate
21%
ferrous sulfate
20%
ferrous gluconate
12%
levothyroxine iv po
0.75:1
furosemide iv:po
1:2
morphine IV:PO
10:30
Hydromorphone IV PO
1.5:7.5
the rabai needs prayer for comfort VITAMINS
thiamine B1 riboflavin B2 niacin B3 pyroxidine B6 folate B9 cyanocobalmin B12
TDD for insulin type 1
0.5u/kg/day using total BW
LDL equation
TC-HDL-TG/5
MWQ=
sensitivity requirement/0.05
test for fungus
koh
catapres change
weekly
DAYtrana patch
up to 9 hours/day
apply to hip
duragesic (fentanyl patch)
1 patch every 72 hours
opioid tolerance is
60 mg morphine/day taken for 1 week!
butrans patch
every 7 days
flector (diclofenac) patch
1 patch twice daily
lidoderm patch
12 hours/day
12 hours on 12 hours off
transderm scop
apply 4 hours before exposure, leave on up to 3 days
oxytrol (oxybutynin) for OAB patch
one patch twice a week
minivelle and vivelle dot (estradiol) patches
one patch twice weekly
xulane patch (OC)
one patch each week for 3 weeks then one week off
androderm patch
daily patch, once a dau
exelon (rivastigmine)
for alzheimers dementia
1 patch everyday
neupro (rotigotine patch)
parkinsons or RLS
one patch everyday
emsam (selegiline) depression
one patch everyday
nicoderm
one patch a day
apixiban DVT/PE treatment dose
10mg BID for 7 days, then 5mg bid
pradaxa afib
CRCL >30: 150mg BID
CRCL 15-30: 75mg BID
xarelto DVT/PE treatment dose
CRCL >30: 15mg BID x 21 days then 20 mg QD
xarelto afib dose
crcl >50: 20 mg QD
crcl 15-50: 15 mg QD
edoxaban general dose
60 mg QD
if crcl less than 50 : 30 mg QD
avoid edoxaban if
crcl >95 or <15
cisplatin antidote
amifostine (prevent nephrotoxicity)
doxorubicin antidote
dexrazoxane
zinecard-prevents cardiomyopathy
totect-treats extravasation
flurouricil
leucovorin (enhances efficacy)
fluroouricil or capecitibine antidone
uridine triacetate (vistogaurd) overdose
ifofosfamide
mesna (mesnex)
irnotecan
atropine-acute
loperamide-delayed
methotrexate
leucovorin
glucarpidase
drugs for neutropenia ANC <1000
filgrastam (neupogen)- daily
pegfilgrastam (neulasta)- once per chemo cycle
sargramostim
sargramostime is
GM-CSF
G-CSF is
filgrastam
for anticipatory N/V before chemo
give ativan
best place to apply testosterone gels
shoulder/upper arms
lotrel
amlodipine/ benzapril
exforge
amlodipine/valsartan
twynsta
amlodpine/ telmesartan
azor
amlodipine/olmesartan
TRIbenzor
amlodipine/olmesartan/HCTZ
caduet
amlodipine+atorvastatin
consensi
amlodipine+ celecoxib
entresto
sacubitril+valsartan
bidil
isosorbide dinitrate+hydralazine
aggrenox
asa+ ER dipyridamole
twinrix
hep A + hep B greater than 18 yo
proquad
MMR+ varicella
pediarix
Dtap+IPV+HEP B
stalevo
carbidopa+levodopa+entacepone
epzicom is
abacavir/lamivudine (check *5701)
trizivir contains what
abacavir so check 5701
retrovir
zidovudine
viread
TDF (nrti)
isentress
raltegravir (insti)
tivicay
dolutegravir (insti)
triumeq
*preferred regimine
abacavir/ lamivudine/ dolutegravir (5701)
dovato
dolutegravir/lamivudine ( do means 2 in some languages)
biktarvy
good regime!
bictegravir/emtricitabine/TAF
aTRIpla
has 3 drugs
efavirenz/TDF/emtricitabine
not currently a preferred regimen
norvir
ritonavir
prezista
darunavir
reyataz
atazanavir
methotrexate dosing with RA
what to give with it
weekly
folate
methotrexate MOA
sphase
antimetabolite
methotrexate SE
Mucositis
Myleosupression
Hepatotoxicity
Photosensitivity
Rash
Renal
X-preg cat X
X-chest xray pulmonary fibrosis
LefLunomide (Arava)
long half life Liver stuff (increase AST and ALT) and alopecia
check ALT every month for the first 6 months
dont use if liver impaired
Preg. category X
sulfasalazine can cause
orange -yellow discoloration of skin lenses and urine
used for RA and UC
xeljanx
tofacitinib PO JAK inhibitor
anakinra
kineret (interlukin 1 receptor antagonist)
biologic DMARDs
TNF blockers
1) adalimumab- humira
2) etanercept- enbrel
3) infliximab- remicade
4) golimumab- simponi
5) certolizumab- cimzia
montelukast dosing
major side effect
1-5: 4mg
6-14: 5 mg
QHS
neuropsychic events
proair, proventil, ventolin
albuterol
xopenex
levoalbuterol
salmeterol
LABA (servent diskus)
beclomethasone
qvar
pulmiCORT
budesonide
SYMbiCORT
budesonide+formoterol
flovent
fluticasone
arnuity ellipta
fluticasone
ADvair
fluticasone+salmeterol
breo ellipta
fluticasone + vilanterol
asmanex
mometosone
DUlera
mometasone+ formoterol
tiotropium
spiriva respimat
umedclidinium
incruse ellipta
spiriva handihaler has
the capsule
all respiclicks are
dry powder
do you have to prime and shake MDIs
yes
how to breath for MDI
slowly and deeply
how to breath for DPI
quickly
HFAs are
MDIs that you shake and prime
breathe slowly and deeply
can use spacers for
MDI formulations
pulmicort flexhaler is
DPI it’s the only one you prime at the beginning
quickly and deeply with DPI
asmanex twisthaler is
DPI
all elliptas are
DPI
avoid bisphosphonates in crcl less than
30
diskus are
DPI
symbicort
DPI
dulera
for mom
MDI
montelukast, zafrilukast MOA
leukotriene receptor antagonist (work on receptors)
zileuton (zyflo) MOA
5-lipooxygenase pathway inhibitor (pathway)
acyclovir can cause
renal toxicity
first line for all severe fungal infections
amphotecerin B
no steroid in
COPD
handihaler
DPI
respimat
PTOP prime turn open press
albuterol/ipatropium
combivent CopD
always load before
you breathe out
interferon side effects
fatigue
depression
flu like syndrome
liver damage
roflumilast (daliresp)
suicidality weight loss copd maintence last line pde4 inhibitor cyp 3a4 sub liver
aNOro ellipta has
no steroid
just umeclidium and vilanterol
servent diskus is ___ alone
salmeterol alone
combos inhalers
symbicort advair + airduo breo ellipta dulera anoro trelegy
ICS/ LABA combos
advair
symbicort
breo ellipta
dulera
ipatroopium
atrovent
combivent respimat
ipatropium and albuterol
symbicort and dulera are
MDIS
no DPIs in what allergy
milk protein
1st line tx for sponteous bacterial peritonitis
ceftriaxone
sofosbuvir (eplcusa)+amiodarone what happens
severe bradycardia
ribavirin main counseling
and SE
can cause birth defects
hemolytic anemia
natural product used to liver dx
milk thistle
kcl 10%=
20MEq/15ml
rapid acting IM injectable antipyschotics
(HZZ)
haloperidol
ziprasidone (geodon)
zprexa (olanazapine)
long acting IM injectable antipsychotics
halodol ORAL fluphenazine risperidone (risperidone consta) risperidone (perseris) SQ paliperidone palimate invega sustenna invega trinza abilify maintena abilify aristada aristada intitio zyrexa relprevv
risperidal contsa given
IM every 2 weeks
po for 3 weeks then stop
invega sustenna given
once a month
invega TRInza given
every 3 months
abilify maintena
once monthly
abilify aristada
every 4 to 6 weeks
aristada initio
only to be given as a booster in a single dose
clozapine =
REMS agranulocytotis
physician patient and pharmacy have to be registered to look at ANC base line must be at least 1500
ORTHOSTATIC HYPOTENSION
SEIZURES
MYOCARDITIS
! boxed warnings
quietapine (seroquel) dosage forms
only comes in tablets
and XR
must take ziprasidone (geodon) with ___
food! can decrease absoprtion up to 80 percent
geodon GEODON GOOD MEAL
ziprasidone is know for
QT prolongation
and no weight gain
check electrolytes before starting
contact doctor if have a rash
latuda with the
fooda (lurasidone)
lowest to no weight gain anti psychotics
ziprasidone, lurasidone, aripiprazole
phenbarb level
20-40
enhances GABA
phenytoin and phenobarb shouldnt be given faster than
50mg/per min
phenytoin/fosphenytoin main things
sedation rash gingival hyperplasia hepatoxicity hair growth
phenytoin/fosphenytoin level
10-20
valproic acid MOA
increase gaba
phenytoin and fospehen MOA
na channel blocker
valproic acid range
50-100
vaLProic acid black box warnings
hepatic failure
pancreatitis
teratogenic
never use valproic acid if
pregnant in migraine prophylaxis
valproic acid increases
lamictal (so lower the dose of lamictal)
carbamazepime looks like
looks like cyclobenzaprine and tcas
-anticholingeric
CArbAmAzePine SEs
boxed warning: SEVERE SJS/TEN, aplastic anemia, agranulocytosis
seperate 14 days from MAOIs fetal harm siadh photosensitivity monitor liver
carbamazepine CI if
prior myleosupression
carbamezapmine MOA
na channel blocker
gabapentin is 100% _____
renal, dose adjust
causes peripheral edema
pregabalin is 100% ____
renal, dose adjust
causes peripheral edema
lamotrigine main thing
RASH RASH RASH
topiramate and zonisamide and topamax can cause
kidney stones, weight loss, and decrease sweating(hyperthermia)
sulfa allergy with which anticonvulsant
zonisamide
topamax is renal or liver
RENAL
topiramate is preg category
D
topiramate can cause metabolic __
acidosis
lacosamide! Vimpat SE
heart block, pr prolongation
chedule V
vigabatrin (sabril) can cause
vision loss!
all seizure meds cause
sedation/ somnolence,
suicidal thinking and behavior
active metabolite of oxcarbazepine
eliscarbepine
epidiolex (cannabidiol) for seizures
only for sever seixures
LGS
and dravet syndrome
- weight loss and watch liver
- monitor ALT, AST
smoke less than 25 cigs/day (20 in a pack) what gum to choose
if smoke greater than 25 in day
2mg
4 mg
max gums they can chew a day 24 pieces
avoid lithium with
NSAIDS, choose tylenol instead or ASA
kadian is
morphine
methadone can cause
QT prolongation, can also use it do get off opioids hecause of NMDAreceptor anatagonist
no thiazides or loops with sulfa allergy except
EA
hyzaar
losartan/hctz
dyazide
hctz/triamtere
altace
ramipril
mycelex
clortimazole, oral thrush
esas only when hgb is
less than 10, interupt when it exceeds 12
hyperphosphatemia
calcium acetate (phoslo, phoslyra)
sevelamer (renagel, renvela)
lanthanum (fosrenol)
alumnium hydroxide (ampho gel)
zanaflex
tizanadine
valtrex
valacyclovir
vibramycin
doxycycline
ziac
bisoprolol/ hctz
levophed
norepi works on alpha and beta
jantoven
dabigatran
divaloprex/valpproic acid effect on weight
increase
lithium effect on weight gain
increase
lanoxin
digoxin
reclast
zoledronic acid
tenormin
atenolol
antidote for methanol and etylene glycol toxicity is
fomepizole
ESRD have what electrolyte abnormalities
hyperkalemia,
hyperphosphatemia
low hemoglobin
beta blockers with intrinsic sympathomemetic activity
APP
acebutolol
pindolol
pentbutolol
no FQs or bactrim with
warfarin
3 electrolytes to monitor in DKA
potassium
magnesium
phosphate
drugz used to treat chemo induced anemia
aranesp, epogen or procrit
epzicom and trizir have
abacavir so must test 5701
iv PPIS
esomeprazole and pantoprazole
ghonorrhea tx
ceftriazone 500 mg IM injection
urine bugs PEKEPS
proteus ecoli klebsiella enterococci pseudomanas staph saprophyticus
tylenol kids
10-15/mg/kg/dose
carbamazepine causes
agranulocytosis
common SE with brillinta
dyspnea
ABx that dont require renal dose adjustmnet
oxacillin, nafcillin, moxifloxacin, ceftriaxone, clindamycin, linezolid and tigecycline
prasugrel
effient
ticagrelor
brilinta
cangrelor
kengreal
zegrid
omeprazole+ sodium bicarb
eltegravir always needs to be
boosted
do not use amiodarone with HCV drugs containing
sofosbuvir (epclusa, harvoni)
hep b preferred treatment
interferon alfa or nrti (tenofovir or entecavir)
vemlidy/viread
-previr
hcv
ns3/4a
-asvir
n35A
-buvir
ns5B
number of dissociation particles
calcium chloride-
sodium citrate-
cacl2-3
na3c6h5o7-4
number of dissociated ions related to dissociation fator
1=1 2=1.8 3=2.6 4=3.4 5=4.2
valence of 2
all the calcium ones
ferrous, lithium, magnesium
the chelation ones
valence of 1
potassiums sodiums ammoniums
1 oz= how many g
28.4g
1 lb to g
454 g
1 grain to mg
65 mg
humalog mix pens
10 days
humulin r vials
31 days
humulin n, n/r pens
14 days
humulin r u-500 viAL
40 DAYS
NOVOLIN R, N, N/R 70/30 vial
42 days
novolog mixes in pens
14 days
levemir (detemir)
42 days
degludec (tresiba)
56 days
toujeo pen
56 days
