RA drugs

Question 1

hydroxychloroquine

Answer 1

stabilizes lysosomes and decreases chemotaxis.

Question 2

se of hydroxychloroquine

Answer 2

GI and visual distress. cinchonism, hemolysis in G6pD def.

Question 3

methotrexate

Answer 3

cytotoxic to lymphcytes

Question 4

se of methotrexate

Answer 4

hematoxicity

Question 5

sulfasalazine

Answer 5

decreases b cell function and inhibits COX

Question 6

se of sulfasalazine

Answer 6

hemolysis in G6PD

Question 7

glucocorticoids

Answer 7

decreases LTs, ILs, PAF

Question 8

what are the SE of glucocorticoids

Answer 8

ACTH suppression, cushingoid state, osteoporosis, GI distress, glaucoma.

Question 9

gold salts

Answer 9

decreased lysosomal and macrophage functions

Question 10

se of gold salts

Answer 10

dermatitis, hematotoxicity, nephrotoxicity

Question 11

leflunamide

Answer 11

inhibits dihydroorotic acid dehydrogenase. arrests lymphs in the G1 phase.

Question 12

se of leflunamide

Answer 12

alopecia, rash, diarrhea, hepatotoxic.

Question 13

enteracept

Answer 13

recombinant TNF-receptor binds TNF.

Question 14

SE of enteracept

Answer 14

infections

Question 15

infliximab

Answer 15

anti TNF AB

Question 16

SE of infliximab

Answer 16

infections

Question 17

anakinra

Answer 17

IL-1 receptor antagonist

Question 18

se of anakinra

Answer 18

infections