gout treatment

Question 1

what do we use to treat the pain of gout

Answer 1

indomethicin, naproxen or sulindac. intraarticular steroids.

Question 2

colchicine

Answer 2

binds to tubulin and decreases microtubular polymerization. decreases LTB4. decreases leukocyte and granulocyte migration.

Question 3

SE of cholchicine short term

Answer 3

diarrhea, GI pain

Question 4

long term SE of cholchicine

Answer 4

hematuria, alopecia, myelosuppression. gastritis, peripheral neuropathy

Question 5

what is the goal of prophylaxis for gout

Answer 5

decrease the uric acid pool

Question 6

allopurinol

Answer 6

inhibits xanthine oxidase as a suicide inhibitor and decreases the purine pool and thus uric acid

Question 7

SE of allopurinol

Answer 7

rash and hypoxanthine stone.

Question 8

what is the most important interaction for allopurinol

Answer 8

inhibits the metabolism of 6-mercaptopurine and causes this to build up in the serum. when used efficiently this can decrease the dose of chemo used.

Question 9

probenacid

Answer 9

inhibits proximal tubule reabsorption of urate.

Question 10

SE of probenacid

Answer 10

inhibits the secretion of other acids as well. when there is high excretion of uric acid there can be crystalization