fat drugs Flashcards
statin agents
lovastatin, ends in statin
mechanism of the statin
inhibits HMG-CoA reductase. this increases the LDL receptor and thus removes LDL from the blood. there is decreased VLDL synthesis and thus lower TG.
SE of the statins
myalgia, myopathy, rhabdomyolysis, hepatotoxicity
what are the interactions for the statins
increased risk for rhabdo with gemfibrozil. cytochrome p450 inhbitors enhance the toxicity of the statins.
what are the agents for bile acid sequesterants
cholestyramine and colestipol.
what is the mechanism of bile acid sequesterants
complexation of bile salts in the intestine. this decreases the circulating bile salts increasing their synthesis which decreases the LDL.
SE of the bile sequesterants
there is increased VLDL and TG. GI disturbances (steatorrhea), lipid vitamin malabsorption.
what are the interactions with bile sequesterants
warfarin, digoxin, thiazides
what are the contraindications for bile sequesterants
hypertriglyceridemia
what is the mechanism for niacin
inhibits VLDL synthesis. this will lower the LDL and increase the HDL.
SE of niacin
flushing, pruritis, rashes and hepatotoxicity
fibrate agents
gemibrozil and fenofibrate.
what is the mechanism of the fibrates
binds to the PPAR-alpha and increases the expression of lipoprotein lipases. results in decreased VLDL, IDL and increased HDL.
SE of the fibrates
gallstones and myositis
what is the mechanism of ezetimibe
prevents the intestinal absorption of cholesterol, decreasing the LDL.
