RA Flashcards
What are the symptoms of RA?(5)
Pain in joints Stiffness and swelling in joints High grade systemic inflammation Fatigue Depression
RA is an _____ disease
Autoimmune
How can disease activity of RA be assessed?(3)
DAS28
Inflammation
Joint health (radiography)
Explain the inflammatory cycle (5)
Chronic inflammation leads to loss of muscle mass and increase in metabolic disorders
This decreases PA
Low PA Increase adiposity
Adipose tissue releases pro-inflammatory cytokines
Despite the known benefits, RA patients are ______ ______ ______than their healthy peers
Less physically active
What do physios, RA patients and rheumatologist perceive the optimal type physical activity for RA patients? (3)
Munneke 2004
Low intensity better than high intensity
Despite the evidence for the effectiveness and safety of high intensity exercise
Strasser 2010 combination training findings (3)
A combination of strength and endurance training resulted in improvements in muscle strength and functional ability
Long term effects appeared to reduce disease activity
Munneke 2005 high intensity negative (3)
High intensity weight bearing exercise appears to accelerate joint damage
In patients with preexisting extensive damage
Advices patients with extensive joint damage should refrain from exercise
How does inflammation induce muscle loss?
TNF-a stimulates muscle protein break down
According to Kasapis 2005, how does PA reduce inflammation?(3)
IL6 released during PA inhibits TNF-a production and induces IL10 production
IL10 is an inflammatory cytokine
Findings by Rahnama 2012 aerobic v strength (3)
Aerobic training improves functional and walking ability
Strength training has improved knee range or motion
They equally relieve pain
De Jong 2004 long term radiological damage (4)
Examined the effects of long term high intensity weight bearing exercises on radiological damage of joints
After 2 years, high intensity group developed less radiological damage than the control group
Also decrease in disease activity and improved aerobic fitness
Munsterman 2013 depression aerobic capacity fatigue (3)
Found depression to be related to fatigue
However there was no relationship between aerobic capacity and fatigue
May indicate greater inflammation (sick behaviour)
Rosenilda 2004 walking EE (3)
Patients with RA expended more energy walking compared to the healthy controls, under the same conditions
This indicates reduced functional mobility
Ekdahl 1992 strength comparison (2)
Showed that the RA patients had sig reduced muscle strength and endurance
In comparison to the healthy participants
