RA

Question 1

most common sites of inflammation

Answer 1

small joints of hand

Question 2

pathophys

Answer 2

CD4 & Th1 cells:

1.Activate B cells
B cells produce RF, which inc inflam and inc CRP

2. Activates monocytes, macrophages & synovial fibroblasts

Secrete TNF-a, IL-1, IL-6

Inc angiogensis in synovium
Inc inflam cell recruitment
Osteoclast activation

Question 3

Ix

Answer 3

Bloods - RF & anti-CCP antibody
raise CRP & ESR
XR

Question 4

Mgx

Answer 4

Exercise
Physio
DMARDs (dec inflam) - methotrexate, sulfasalazine
Biologics (block cytokines)
Anti-flares - NSAIDs, glucocorticoids
Surgery