Depression Flashcards
3 typical core symptoms
Low mood
Anhedonia - low interest/pleasure in most activities
Lack of energy (anergia)
Psychotic symptoms
Delusions
Hallucinations
what criteria is used to diagnose a depressive episode?
ICD-10/ICD-11 criteria
Mild depression
Two typical core symptoms, two other core symptoms
Moderate depression
two typical core symptoms, three other core symptoms
Severe depression
all three typical core symptoms, four other core symptoms
Mild depression Mgx
watchful waiting
Problem solving
Exercise
Moderate depression Mgx
- CBT
- SSRI
If psychotic symptoms occur:
- antipsychotic (olanzapine)
severe depression Mgx
Antidepressant + CBT
Hospitalisation + ECP if severe
antidepressants
SSRI
SNRI
SARI
TCA
NaSSA
what do SSRIs do
block serotonin reuptake into neurons
- block 5HT reuptake at dendrites
- Ince 5HT levels
- used to make serotonin
what do SNRIs do?
Inc serotonin and noradrenaline levels in brain
what cells release serotonin
enterochromaffin cells
what do benzodiazepines do?
Inc GABA action
(GABA is calming)
neurotransmitter responsible for mood and cognition
Dopamine
