quiz 2 Flashcards
health
the absence of disease
disease/disorder
associated with signs and symptoms
-symptoms: conditions, illness, disorders
genetic causes
heredity
nutrition causes of disease
Both toxicity and disease
what is the link between genetically caused disorders?
protein
nucleus
DNA house
DNA (gene)
recipe we make proteins from
mRNA
copy of recipe (or DNA)
cytosol
cytoplasm - protein is built
ribosome
work bench - where it is being made
tRNA
transport individual amino acid to ribosome to continue making the new string of AA
amino acids
building blocks
polypeptide
protein
gene expression
appearance of a protein
link between genetically caused disorders
protein
what is the result of not having genetic code for a protein
none of that protein
what is the result of having a faulty genetic code for a protein
faulty protein or protein wont work
lactose intolerance genetically linked
missing lactase or faulty code
lactose intolerance environmental caused
use it or lose it
- not eating dairy means the body doesnt need to make lactase anymore
inborn error in metabolism of lactose is
genetics
treatment for lactose intolerance
eating dairy/ lactose
fermentation
bacteria id added to milk
-bacteria metabolism sugar
lactaid
allows lactaid to survive
type of protein that is creating lactose intolerance
enzyme (lactase)
genetic link for lactose intolerance
lacking genetic code for lactase
galactosemia is an inborn error in metabolism of
galactose
galactosemia in relationship with lactose intolerance
galactose is mainly found in lactase
treatment for galactosemia
stay away from lactose
type of protein that creates galactosemia
GALT
PKU is an inborn error in metabolism
phenylalnine (PHE)
problems with PKU
accumulation of phenylalanine and phenylpyruvic acid
essential amino acid in PKU
tyrosine
treatment for PKU
stay away from PHe and consume tyrosine
-animal proteins, quinoa, complete proteins
-aspartame (fake sugar) - contains Phe
-fruits and veggies in moderation
type of protein causing the problem in pKU
enzyme - PAH
genetic link for PKU
faulty genetic code
-less functional PAH
Cystic Fibrosis in born error of the production of
chloride channels
problems in CF
persistent cough
wheezing and shortness of breath
frequent lung infections
hard time getting O2 in and CO2 out
CF has reduced flow or blocked pancreatic ducts because?
because of cysts and fibrosis
-results in reduced pancreatic juice which leads to a decrease in digestive enzymes
reduced ability to absorb nutrients in SI
due to less efficient digestion
digestive and nutrient concerns with CF
nutrients cant be absorbed well
can lead to deficiences
treatment for CF
PERPS: pancreatic enzyme replacement products (lipase, amylase and protease
chest and upper back physiotherapy
supplemental oxygen
airway clearance techniques
type of protein creating cf in lungs
chloride transporter
DNA is dependent on
vitamins and amino acids
nutrient deficiences create lower ability to make DNA
folate, B6, B12, methionine/ cystine ect
disorders from deficincies
anemia
neural tube defects
epigenetics
changes in DNA expression due to transient internal and external factors
DNA expression
transcription and translation stimulation
more protein
DNA silencing
translation and transcription inhibiting
less protein
internal or external factors of stimulating T and T or silencing
internal = fat, cell, cytokinase
external factors = nutrients/ chemicals
both expression and silencing are caused by
DNA methylation and histone modification
what DNA changes causes different proteins to be present or absent
methylation or histone modification of our DNA
misexpression of proteins
causes different end points
-phenotype
-health status
-resistance to external factors
cytokine production due to fat mass production =
nutrients =
internal factor
external
misexpression of proteins makes you
more susceptibile to illness
nutriepigenetics
changes in DNA expression due to external factors such as dietary nutrient/ chemical availability
fortification of foods
adding nutrients originally present and removed through processing like grains and flour
enrichment of foods
adding more of something