Quinolones; UTIs; Linezolid; -Pristins

Question 1

Ciprofloxacin

Answer 1

• 2nd Generation; Most potent
• Path: UTI, RTI, Prostatitis; Cystic Fibrosis; Conjuctivitis; Otitis Externa
• Bugs: PEcK; H.Flu; Moraxella; Legionella; Enterobacter; Shigella; Salmonella; Campylobacter; Cholera

Question 2

FLQ General

Answer 2

• Bactericidal
• Highly active for Gram - Aerobics
• Inhibit Replication (DNA Gyrase)
• 3 Gens:
  2: Cipro, Ofloxacin
  3: Levofloxaxin, Gemifloxacin

Question 3

Levofloaxacin/Gemifloxacin

Answer 3

• Gram - PLUS extended Gram +
• Path: RTIs; UTI/Prost; Skin infections; Conjunctivitis; Leprosy
• Bugs: *E. Coli; MDRSP; H.Flu, Mora, Kleb, PSeudo, Legion, chlamydia, Mycoplasma

Question 4

Moxi/Gati/Besifloxacin

Answer 4

• Gram -, INC Gram +, INC Anaerobes
• Bugs: Staph/Strep, Bacteroides, Fuso, Peptostrepto; MDRSP; H.Flu, Mora, Kleb, Myco, Chlamydia
• Path: RTIs, Skin infections, conjunctivitis,

Question 5

FQL w/ Renal insufficiency

Answer 5

Moxifloxacin

Question 6

FQL AE

Answer 6

GI, Peripheral Neuropathy, CNS disturbance (Nausea, headache, Dizziness), Tendinitis + Rupture, Aortic dissection/Aneurysm, Crystalluria, Cardiotoxicity, Phototoxicity,

Question 7

FQL Contra + Interaction

Answer 7

• Pregnancy/Nursing/<18
• Hx aneurysm
• Hypertension
• Elderly
• Marfan Syndrome
• Theophylline, Warfarin, Cyclosporine

Question 8

Methenamine Hipprate

Answer 8

• UTI Drug
• RQs conversion to formaldehyde
• SE: GI distress, allergic Rxn, hematuria

Question 9

Nitrofurantoin

Answer 9

• UTI Prodrug
• Disrupt bacterial DNA
• Brown Urine

Question 10

Iinezolid

Answer 10

• Inhibits 50S subunit
• SERIOUS Infections
• MRSA, VISA, VRSA, VRE, MDRSP
• Path: Bacteremia, Pneumnia, Skin/soft tissue, UTIs, endocarditis
• AE: GI, Allergic, Headache/dizziness, Myelosuppression, anemia, + Thrombocytopenia

Question 11

Streptogramins

Answer 11

• “-pristin”
• synergistic Inhibition of Protein synthesis
• Serious infections: VRE, MRSA, VISA, VRSA
• Patho: Bacteremia, Skin/ST, UTIs, Endocarditis
• AE: Infusion phlebitis
• Pharm: Hepatic metabolism