Antivirals Flashcards
Antiherpetic and Anti-CMV
Idoxuridine Vidarabine Trifluridine -Clovirs Cidofovir Fomivirsen
Influenza + RSV
Infl: Amantadine Rimanatadine Oseltamivir Peramivir Baloxair Marboxil
RSV:
Ribavirin
Palivizumab
Nonspecific Antivirals
IF-a + IFN-B Intron A Roofer on A Alferon Wellferon Betaseron Rebetron
Process of activation of antivirals
Phosphorylation
NRTIs
Very Ugly Dinosaur Been (-BINE) Seen (-Sin) Dining (-DINE) in A Cave (Abacavir) with a Ten Of Spades (Tenofovir)
Zidovudine Zalcitabine Didanosine Stavudine Abacavir Lamivudine Adefovir Emtricitabine
NNRTIs
VIRtually few NNRTIs
Nevirapine Delavirdine Efavirenz Etravirine Rilpivirine
HIV protease Inhibitor
Indinavir
Ritonavir
I PREVIR to NAVIR fight Proteus
Saquinavir Lopinavir Amprenavir Atazanavir Fosamprenavir Tipranavir Bocepravir
Enfuvirtide
Binds GP41 prevents binding/fusion
Maraviroc
CCR5 co-receptor binding prevents entry of virus in host
Integrate inhibitors
Prevent provirus integration
Gravity integrates us with the ground
Raltegravir
Dolutegravir
Elvitegravir
HBV
Telbivudine Lamivudine Entecavir Adefovir Vidarabine Tenofovir IFNs
HPV
Imiquimod
HCV
Hep C PREVIRS to SEE (C) a DO
Boceprevir
Telaprevir
Simerevir
Acyclovir
- nucleoside analog; inhibits Viral DNA PM
- HSV1 + 2; VarZ; CMV
- Topical, oral, and IV
- AE: Renal dysfunction
Idoxuridine/Trifluridine
- Various mechanisms including block DNA synthesis
- HSV I
- AE: PArenteral marrow toxicity; Pain, pruritic,edema, and inflammation
Vidarabine
- Adenosine analog; inhibits DNA PM
- IV: HSV encephalitis
- Oral: HSV keratitis
- AE: GI Toxic, anorexia, Hepatic toxicity
Ganciclovir
- Inhibits DNA polymerase; CMV suppression, HSV
- AE: Leuopenia; TCPenia, CNS side affects
Foscarnet
- Inorganic pyrophohate which inhibits viral RNA OM
- HCV and CMV retinitis
- AE: Nephrotoxicity; electrolyte disturbance
Ribavirin
- Purine nucleoside analogue which prevents capping of viral mRNA
- HSV, INF A/B, RSV + Pneum
- AE: Myelosuppression, conjunctival irritation
Cidofovir
- Nucleotide analog inhibit viral DNA PM
- HSV + CMV retinitis
fomivirsen
- Inhibits CMV via antisense mechanism
PI Contras
Rifampin
Influenza A/B primary drugs
Amantadine + Rimantadine:
- Inhibit Replication
- Amantadine also indicated in Parkinsonism
Zanamivir + Oseltamivir (Tamiflu):
- Zabamivir intranasal
- Tamiflu prodrug;
Baloxavir Maboxil: Cap-dependents endonuclease inhibitor in RNA transcription
- >12 YO
Harvoni
Sofosbuvir + Ledipasvir:
- HCV
- NS5a inhibitor
- Expensive, but it shows cure
Palivizumab
- RSV
- Human Mnoclonal Ab against F glycoprotein in RSV surface
- AE: Elevation of aminotranferase enzymes
Interferons
- Most viral replication stages
- HepB, HepC, Kaposi’s sarcoma (HIV), Pappillomatosis + Topical genital warts
- AE: Neutropenia, GI, fatigue, myalgia, cardiomyopathy, CNS disturbance
Fusion Attachment inhibitor
Maraviroc
Fusion penetration inhibitor
Enfuvirtide
Integrate inhibitor
Raltegravir
Protease inhibitors
“Navir”
- Lopinavir
- Atazanavir
- Indinavir
Viral Uncoating drugs
Amantadine
Rimantadine
Neuroaminidase inhibitor
“Mivir”
Zanamivir
Oseltamivir
Nucleic Acid inhibitors
Guanine: Ribovirin
Viral DNA PM: Foscarnet + Cidofovir
Guanisine Analogs: Acyclovir + Ganciclovir
