Antivirals

Question 1

Antiherpetic and Anti-CMV

Answer 1

Idoxuridine
Vidarabine
Trifluridine
-Clovirs
Cidofovir
Fomivirsen

Question 2

Influenza + RSV

Answer 2

Infl:
Amantadine
Rimanatadine
Oseltamivir
Peramivir
Baloxair Marboxil

RSV:
Ribavirin
Palivizumab

Question 3

Nonspecific Antivirals

Answer 3

IF-a + IFN-B
Intron A
Roofer on A
Alferon
Wellferon 
Betaseron
Rebetron

Question 4

Process of activation of antivirals

Answer 4

Phosphorylation

Question 5

NRTIs

Answer 5

Very Ugly Dinosaur Been (-BINE) Seen (-Sin) Dining (-DINE) in A Cave (Abacavir) with a Ten Of Spades (Tenofovir)

Zidovudine
Zalcitabine
Didanosine
Stavudine
Abacavir
Lamivudine
Adefovir
Emtricitabine

Question 6

NNRTIs

Answer 6

VIRtually few NNRTIs

Nevirapine
Delavirdine
Efavirenz
Etravirine
Rilpivirine

Question 7

HIV protease Inhibitor

Answer 7

Indinavir
Ritonavir
I PREVIR to NAVIR fight Proteus

Saquinavir 
Lopinavir
Amprenavir
Atazanavir
Fosamprenavir
Tipranavir
Bocepravir

Question 8

Enfuvirtide

Answer 8

Binds GP41 prevents binding/fusion

Question 9

Maraviroc

Answer 9

CCR5 co-receptor binding prevents entry of virus in host

Question 10

Integrate inhibitors

Answer 10

Prevent provirus integration

Gravity integrates us with the ground

Raltegravir
Dolutegravir
Elvitegravir

Question 11

HBV

Answer 11

Telbivudine
Lamivudine
Entecavir
Adefovir
Vidarabine
Tenofovir
IFNs

Question 12

HPV

Answer 12

Imiquimod

Question 13

HCV

Answer 13

Hep C PREVIRS to SEE (C) a DO

Boceprevir
Telaprevir
Simerevir

Question 14

Acyclovir

Answer 14

• nucleoside analog; inhibits Viral DNA PM
• HSV1 + 2; VarZ; CMV
• Topical, oral, and IV
• AE: Renal dysfunction

Question 15

Idoxuridine/Trifluridine

Answer 15

• Various mechanisms including block DNA synthesis
• HSV I
• AE: PArenteral marrow toxicity; Pain, pruritic,edema, and inflammation

Question 16

Vidarabine

Answer 16

• Adenosine analog; inhibits DNA PM
• IV: HSV encephalitis
• Oral: HSV keratitis
• AE: GI Toxic, anorexia, Hepatic toxicity

Question 17

Ganciclovir

Answer 17

• Inhibits DNA polymerase; CMV suppression, HSV

- AE: Leuopenia; TCPenia, CNS side affects

Question 18

Foscarnet

Answer 18

• Inorganic pyrophohate which inhibits viral RNA OM
• HCV and CMV retinitis
• AE: Nephrotoxicity; electrolyte disturbance

Question 19

Ribavirin

Answer 19

• Purine nucleoside analogue which prevents capping of viral mRNA
• HSV, INF A/B, RSV + Pneum
• AE: Myelosuppression, conjunctival irritation

Question 20

Cidofovir

Answer 20

• Nucleotide analog inhibit viral DNA PM

- HSV + CMV retinitis

Question 21

fomivirsen

Answer 21

• Inhibits CMV via antisense mechanism

Question 22

PI Contras

Answer 22

Rifampin

Question 23

Influenza A/B primary drugs

Answer 23

Amantadine + Rimantadine:

• Inhibit Replication
• Amantadine also indicated in Parkinsonism

Zanamivir + Oseltamivir (Tamiflu):

• Zabamivir intranasal
• Tamiflu prodrug;

Baloxavir Maboxil: Cap-dependents endonuclease inhibitor in RNA transcription
- >12 YO

Question 24

Harvoni

Answer 24

Sofosbuvir + Ledipasvir:

• HCV
• NS5a inhibitor
• Expensive, but it shows cure

Question 25

Palivizumab

Answer 25

• RSV
• Human Mnoclonal Ab against F glycoprotein in RSV surface
• AE: Elevation of aminotranferase enzymes

Question 26

Interferons

Answer 26

• Most viral replication stages
• HepB, HepC, Kaposi’s sarcoma (HIV), Pappillomatosis + Topical genital warts
• AE: Neutropenia, GI, fatigue, myalgia, cardiomyopathy, CNS disturbance

Question 27

Fusion Attachment inhibitor

Answer 27

Maraviroc

Question 28

Fusion penetration inhibitor

Answer 28

Enfuvirtide

Question 29

Integrate inhibitor

Answer 29

Raltegravir

Question 30

Protease inhibitors

Answer 30

“Navir”

• Lopinavir
• Atazanavir
• Indinavir

Question 31

Viral Uncoating drugs

Answer 31

Amantadine

Rimantadine

Question 32

Neuroaminidase inhibitor

Answer 32

“Mivir”

Zanamivir
Oseltamivir

Question 33

Nucleic Acid inhibitors

Answer 33

Guanine: Ribovirin

Viral DNA PM: Foscarnet + Cidofovir

Guanisine Analogs: Acyclovir + Ganciclovir